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Fluid Mechanical Factors in Macromolecular Transport by the Arterial Wall

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Abstract

There is considerable evidence that hemodynamic factors may alter the arterial wall transport process and contribute to atherogenesis [1,2, 3]. The purpose of this presentation is to summarize some of our investigations on macromolecular uptake by the arterial wall as affected by oscillatory mechanical disturbance and pressure variations and on the regional variation of uptake in relation to ultrastructure and hemodynamics.

Supported by U.S.P.H.S. Grant HL19454 from NHLBI and NSF Grant ENG7822101

Presented by Professor S. Weinbaum, City College of New York

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References

  1. Fry DL (1973) Responses of the arterial wall to certain physical factors. In: Atherogenesis: Initiating factors. Ciba Foundation Symposium 12 (new series). Associated Scientific Publishers, Amsterdam, pp 93–125

    Google Scholar 

  2. Nerem RM, Guyton JR (1980) Hemodynamics and the arterial wall. Proceedings from a Specialists Meeting sponsored by National Science Foundation, University of Houston and Baylor College of Medicine. University of Houston, Tx

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  3. Caro GG (1981) Arterial fluid mechanics and atherogenesis. Recent Adv Cardio-vasc Dis (Nat. Cardiovasc. Center, Suita, Osaka, Japan), vol II [Suppl], pp 6–11

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  4. Chien S, Lee MML, Laufer LS, Handley DA, Weinbaum S, Caro CG, Usami S (1981) Effects of oscillatory mechanical disturbance on macromolecular uptake by arterial wall. Ateriosclerosis 1: 326–336

    Article  CAS  Google Scholar 

  5. Weinbaum S, Chien S (1980) Vesicular transport of macromolecules across vascular endothelium. In: Gross JF, Popel AS (eds) The mathematics of microcirculation phenomena. Raven Press, New York, pp 109–131

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  6. Chien S, Weinbaum S (1981) Vesicle transport in arterial endothelium and the influence of mechanical factors on macromolecular permeability. J Biomech Eng 103: 186–196

    Article  PubMed  CAS  Google Scholar 

  7. Thurn AL (1982) Effects of endothelial injury on macromolecular transport in the arterial wall. Ph.D. Dissertation, Columbia University

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  8. Schultz DL (1972) Pressure and flow in large arteries. In: Bergel CH (ed) Cardiovascular fluid mechanics, vol 1. Academic Press, New York

    Google Scholar 

  9. Caro CG, Pedley TJ, Schroter RC, Seed WA (1978) The mechanics of the circulation. Oxford University Press, Oxford

    Google Scholar 

  10. Stein PD, Sabbah HN, Anbe DT, Walburn FJ (1979) Blood velocity in the abdominal aorta and common iliac artery of man. Biorheology 16: 249–255

    PubMed  CAS  Google Scholar 

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© 1983 Springer-Verlag Berlin Heidelberg

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Chien, S. (1983). Fluid Mechanical Factors in Macromolecular Transport by the Arterial Wall. In: Schettler, G., Nerem, R.M., Schmid-Schönbein, H., Mörl, H., Diehm, C. (eds) Fluid Dynamics as a Localizing Factor for Atherosclerosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69085-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-69085-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69087-7

  • Online ISBN: 978-3-642-69085-3

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