Abstract
18-hydroxycorticosterone is produced predominently in the zona glomerulosa and has been considered a major and immediate precursor of aldosterone [1, 2], an assumption based on the parallel increase in both 18-hydroxycorticosterone and aldosterone secretion in response to specific stimuli such as sodium restriction. It has, therefore, been expected that determinations of 18-hydroxycorticosterone could prove to be of considerable diagnostic value in patients with the various types of primary aldosteronism [3–7]. Indeed, increased secretion rates and plasma concentrations of 18-hydroxycorticosterone in this syndrome have been reported [4, 6]. In the present paper, three aspects of the diagnostic value of 18-hydroxycorticosterone will be analyzed: (1) Its usefulness in differentiating patients with aldosterone-producing adenomas from those with hyperaldosteronism due to adrenal hyperplasia; (2) the role of 18-hydroxycorticosterone as a possible early marker in the diagnosis of primary aldosteronism; and (3) three cases each of hypertension, elevated excretion of 18-hydroxycorticosterone but normal aldosterone levels, and adrenal adenoma will be presented.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ulick S (1976) Diagnosis and nomenclature of the disorders of the terminal portion of the aldosterone biosynthetic pathway. J Clin Endocrinol Metab 43: 92–96
Neher R (1979) Aldosterone: chemical aspects and related enzymology. J Endocrinol 81: 25–35
Fraser R, Lantos CP (1978) 18-hydroxy-corticosterone: A Review. J Steroid Biochem 9: 273
Ulick S, Nicolis GL, Vetter KK (1964) Relationship of 18-hydroxy-corticosterone to aldosterone. In: Baulieu EE, Röbel P (eds) Aldosterone. Blackwell, Oxford, pp 3–17
Vecsei P, Purjesz I, Wolff HP (1969) Studies on the biosynthesis of aldosterone in solitary adenoma and in nodular hyperplasia of the adrenal cortex in patients exhibiting Conn’s syndrome. Acta Endocrinol (Copenh) 62: 391–398
Biglieri EG, Schambelan M (1979) The significance of elevated levels of plasma 18-hydroxy-corticosterone in patients with primary aldosteronism. J Clin Endocrinol Metab 49: 87–91
Abdelhamid S, Vecsei P, Haack D, Gless K-H, Walb D, Fiegel P, Lichtwald K (1981) Elevated “free” 18-hydroxy-corticosterone excretion as a possible indicator for early diagnosis of primary aldosteronism. J Steroid Biochem 14: 913–920
Connolly TM, Vecsei P, Haack D, Kohl K-H, Abdelhamid S, Amenti (1978) Aldosterone diagnosis in hypertension: comparative evaluation of radioim¬-munoassays for urinary aldosterone and 18-OH-corticosterone. Klin Wochen sehr [Suppl 1] 56: 173–181
Vecsei P, Penke B, Joumaah A (1972) Radioimmunoassay of free aldosterone and of its 18-oxo-glucuronide in human urine. Experientia 28: 730–732
Kohl K-H, Vecsei P, Abdelhamid S (1978) Radioimmunoassay of tetrahydro aldosterone ( Th-Ald) in human urine. Acta Endocrinol (Copenh) 85: 596–608
Vecsei P, Benraad TJ, Hofmann J, Abdelhamid S, Haack D, Lichtwald K (1982) Direct radioimmunoassays for “Aldosterone” in unprocessed urine, and their use in screening to distinguish primary aldosteronism from hypertension. Clin Chem 28: 453–456
Schöneshöfer M, Fenner A, Dulce HJ (1980) Interferences in the radioim-munological determination of urinary free Cortisol. Clin Chim Acta 101: 125–130
Ulick S, Vetter KK (1962) Identification of two C18-ocygenated corticosteroids isolated from human urine. J Biol Chem 237: 3364–3368
Beauwens R, Crabbe J, Birmingham MK (1980) Stimulation of sodium trans port by 18-hydroxydeoxycorticosterone, 18-hydeoxycorticosterone and aldosterone in the toad skin. Physiologist 23: 171
Huston G, Martin VI, Al-Dujaili EAS, Edwards CRW (1981) Evaluation of the mineralocorticoid activity of 18-hydroxycorticosterone. Clin Sci 61: 201–206
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Abdelhamid, S., Vecsei, P., Panitz, N., Christl, H.L. (1983). The Diagnostic Value of Urinary Free 18-Hydroxycorticosterone in Primary Aldosteronism. In: Kaufmann, W., Wambach, G., Helber, A., Meurer, KA. (eds) Mineralocorticoids and Hypertension. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69081-5_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-69081-5_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12391-0
Online ISBN: 978-3-642-69081-5
eBook Packages: Springer Book Archive