Zusammenfassung
Patienten mit Diabetes mellitus weisen eine erhöhte Inzidenz an Angina pectoris und Hypertonie auf. Daher kann häufig die Behandlung mit β-Adrenozeptoren-Blockem in Betracht gezogen werden. In Tabelle 1 sind verschiedene wichtige Aspekte aufgeführt, die allerdings beim Diabetes mellitus hinsichtlich der adrenergen Kontrolle berücksichtigt werden müssen. Die vorliegende Übersicht beschäftigt sich in erster Linie mit dem Einfluß der β-Blocker auf die normale hypoglykämische Reaktion und mit dem Effekt dieser Medikamente auf die Ketogenese während der Verschlechterung der Diabetes-Einstellung. Die adrenerge Steuerung der Insulinfreisetzung und der Einfluß der β-Blocker auf die Diabetes-Einstellung werden im Beitrag von Björntorp u. Holm ausführlicher behandelt.
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Literatur
Rizza RA, Cryer PE, Gerich JE (1979) Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined α-and β-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. J Clin Invest 64:62.
Sherline P, Lynch A, Glinsmann W (1972) Cyclic AMP and adrenergic receptor control of rat liver glycogen metabolism. Endocrinol 91:680.
Matsushita H, Shimazu T (1980) Chemical coding of the hypothalamic neurones in metabolic control. II. Norepinephrine-sensitive neurones and glycogen breakdown in liver. Brain Res 183:79.
Deibert DC, De Fronzo RA (1980) Epinephrine-induced insulin resistance in man. J Clin Invest 65:717.
Exton JH (1972) Progress in endocrinology and metabolism. Metabolism 21:945.
Dietze G, Wicklmayr M, Hepp KD, Bogner W, Mehnert H, Czempiel H, Henftling HG (1976) On gluconeogenesis of human liver. Accelerated hepatic glucose formation induced by increased percursor supply. Diabetologia 12:555.
Popp DA, Shash SD, Cryer PE (1982) Role of epinephrine-mediated β-adrenergic mechanisms in hypoglycemia in insulin-dependent diabetes mellitus. J Clin Invest 69:315.
Deacon SP, Barnett D (1976) Comparison of atenolol and Propranolol during insulin-induced hypoglycemia. Br Med J 2:272.
Christensen NJ (1974) Plasma norepinephrine and epinephrine in untreated diabetics, during fasting, and after insulin administration. Diabetes 23:1.
Lager I, Blohme G, Smith U (1979) Effect of cardioselective and non-selective β-blockade on the hypoglycemic response in insulin-dependent diabetics. Lancet 1:458.
Garber AJ, Cryer PE, Santiago JV, Haymond MW, Pagliara AS, Kipnis DM (1976) The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man. J Clin Invest 58:7.
Gerich JE, Langlois M, Noacco C, Karam JH, Frosham PH (1973) Lack of glucagon response to hypoglycemia in diabetes: Evidence for an intrinsic pancreatic alpha cell defect. Science 182:171.
Lager I, Jagenburg R, von Schenck H, Smith U (1980) Effect of beta-blockade on hormone release during hypoglycemia in insulin-dependent diabetics. Acta Endocrinol 95:364.
Corrall RJM, Frier BM, Davidson NMcD, French EB (1981) Hormonal and substrate responses during recovery from hypoglycemia in man during beta1-selective and non-selective beta-adrenergic blockade. Eur J Clin Invest 11:279.
Wahren J, Feling P, Cerasi E, Luft R (1972) Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. J Clin Invest 51:1870.
Kuo S-H, Kamaka JK, Lum BKB (1977) Adrenergic receptor mechanisms involved in the hyperglycemia and hyperlactacidemia produced by sympathomimetic amines in the cat. J Pharmacol Exp Ther 22:201.
Clarke WL, Santiago JV, Thomas L, Ben-Galim E, Haymond MW, Cryer PE (1979) Adrenergic mechanisms in recovery from hypoglycemia in man: adrenergic blockade. Am J Physiol 236(2): E147.
Lundborg P, Åström H, Bengtsson C, Fellenius E, von Schenck H, Svensson L, Smith U (1981) Effect of β-adrenoceptor blockade on exercise performance and metabolism. Clin Sci 61:299.
Smith U (1980) Editorial. Adrenergic control of human adipose tissue. Eur J Clin Invest 10:343.
Lager I, Smith U (1982) β-adrenoceptor blockade and recovery from hypoglycemia in diabetic subjects: normalization after lactate and glycerol infusions. Clin Sci 62:131.
Blohme G, Lager I, Lönnroth P, Smith U (1981) Hypoglycemic symptoms in insulin-dependent diabetics. Diab Metab 7:235.
Podolsky S, Pattavina C (1973) Hyperosmolar non-ketotic diabetic coma-a complication of propranolol therapy. Metabolism 22:685.
Lönnroth P, Smith U, Sölvell L (1980) Hyperosmolar non-ketotic diabetes coma. Pathophysiological mechanisms. J Swed Med Assoc 77:4674.
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Smith, U., Lager, I. (1983). Sind β-Adrenorezeptoren-Blocker bei Patienten mit Diabetes mellitus kontraindiziert?. In: Schettler, G., Mörl, H., Lohmann, F.W., Wirth, A. (eds) Metabolische und kardioprotektive Effekte durch Beta-Rezeptorenblockade. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69080-8_3
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