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Subcellular Localization of pp60src in RSV-Transformed Cells

  • Chapter
Retroviruses 2

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 107))

Abstract

In 1911 Rous demonstrated that a retrovirus, subsequently named Rous sarcoma virus (RSV), could cause a tumor in a chicken. Nearly 60 years elapsed before it was shown that a specific virus function encoded by the src gene of RSV was required for the maintenance of the transformed state. Martin (1970) isolated a temperature-sensitive RSV mutant whose properties indicated that the viral transforming gene product is required for transformation, but not for viral replication. Seven years later, Martin’s genetic experiment was provided with a biochemical foundation when Brugge and Erikson (1977) showed that the transformation gene src encoded a 60 000–dalton (60-kd) protein present in RSV-transformed cells. Since 1977, many genes capable of inducing oncogenic transformation, and hence given the generic name onc, have been recognized, and many of the oncogenes’ protein products have been identified. The molecular biology of retroviruses is reviewed extensively and in great detail by Weiss et al. (1982), and the reader is referred to this volume and numerous reviews referenced therein on specific aspects of retrovirology.

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  1. The Rockefeller University, 10021, New York, NY, USA

    James G. Krueger, Ellen A. Garber & Allan R. Goldberg

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  1. James G. Krueger
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  2. Ellen A. Garber
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  3. Allan R. Goldberg
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  1. Department of Microbiology, University of Southern California School of Medicine, 2025 Zonal Avenue HMR 401, 90033, Los Angeles, CA, USA

    Peter K. Vogt

  2. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski

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Krueger, J.G., Garber, E.A., Goldberg, A.R. (1983). Subcellular Localization of pp60src in RSV-Transformed Cells. In: Vogt, P.K., Koprowski, H. (eds) Retroviruses 2. Current Topics in Microbiology and Immunology, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69075-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-69075-4_3

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