Asymmetric Chromosomal Distribution of Endogenous Retrovirus Loci in Chickens and Mice

  • Allan Tereba
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 107)

Abstract

Retrovirus-like sequences have been found in the genomes of a large number of species (Coffin 1982). These sequences are inherited in a Mendelian fashion, appear to be stable loci, and can be considered an integral part of an individual’s genetic makeup. However, analysis of related species (Frisby etal. 1979) and some related sublines (Rowe and Kozak 1980) has revealed that these sequences are probably due to rare integration events following infections of gamete or embryonic tissue. The genetic loci resulting from this unique occurrence in animal virology provide an excellent opportunity to observe the interactions of exogenously introduced DNA with a vertebrate genome in a multitude of cell types and at different stages of differentiation

Keywords

Sucrose Lymphoma Leukemia Recombination Fractionation 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1983

Authors and Affiliations

  • Allan Tereba
    • 1
  1. 1.St. Jude Children’s Research HospitalMemphisUSA

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