Zusammenfassung
Über die vasodilatatorischen Eigenschaften von Verapamil und Gallopamil in der Peripherie liegen zahlreiche Arbeiten vor; einige Untersuchungen sind auch an zerebralen Gefäßen — überwiegend In-vitro-Studien an Basilararterienstreifen — durchgeführt worden (Übersicht bei Flaim 1982). Vlahov u. Enzenross beschrieben 1973 eine Hemmung der durch pH-Erniedrigung ausgelösten Konstriktion der Piagefäße an Katzen in vivo durch lokal verabreichtes Gallopamil (D 600) in Konzentrationen ab 1 mg/1. Demgegenüber sind Wirkungen von Verapamil und Gallopamil auf metabolische Reaktionen im Gehirn bisher nicht untersucht worden.
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Literatur
Berne RM, Rubio R, Curnish RR (1974) Release of adenosine from ischemic brain. Effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides. Circ Res 35: 262–271
Brandt L, Andersson KE, Edvinsson L, Ljunggren B (1981) Effects of extracellular calcium antagonists on the contractile responses of isolated human pial and mesenteric arteries. J Cereb Blood Flow Metabol 1: 339–347
Dora E, Kovách AGB (1982) Effect of acute arterial hypo-and hypertensin on cerebrocortical NAD/NADH redox state and vascular volume. J Cereb Blood Flow Metabol. Im Druck
Dutta P, Mustafa SJ, Jones AW (1980) Effect of adenosine on the uptake and efflux of calcium by coronary arteries of dog (abstract). Federation Proc 39: 530
Fenton PA, Bruttig SP, Rubio R, Berne RM (1982) Effect of adenosine on calcium uptake by intact and cultured vascular smooth muscle. Am J Physiol 242: H707–H804
Flaim SF (1982) Comparative pharmacology of calcium blockers based on studies of vascular smooth muscle. In: Flaim SF, Zelis R, (Hrsg.) Calcium blockers -mechanisms of action and clinical applications. Urban &Schwarzenberg, Baltimore München
Harper AM, Craigen L, Kazda S (1981) Effect of the calcium antagonist, nimodipine, on cerebral blood flow and metabolism in the primate. J Cereb Blood Flow Metabol 1: 349–356
Hayashi S, Toda N (1977) Inhibition by Cd++, verapamil and papaverine of Ca++-induced concentrations in isolated cerebral and peripheral arteries of the dog. Br J Pharmac 60: 35–43
Huang M, Drummond GI (1979) Adenylate cyclase in cerebral microvessels: action of guanine nucleotides, adenosine, and other antagonists. Mol. Pharmacol. 16: 462–472
Ibrahim MZM (1975) Glycogen and its related enzymes of metabolism in the central nervous system. Adv Anat Embryol Cell Biol 52: 1–84
Kovách AGB, Dora E, Szedlacsek S, Koller A (1982) Effect of organic calcium antagonist, D 600, on cerebrocortical vascular and metabolic responses evoked by adenosine, anoxia and epilepsy. J Cereb Blood Flow Metabol, im Druck
McCalden TA, Bevan JA (1981) Sources of activator calcium in rabbit basilar artery. Am J Physiol 241:H129–H133
Nakayama K, Nasuya Y (1980) Selective abolition of Ca-dependent responses of smooth and cardiac muscles by flunarizine. Japan J Pharmacol 30: 731–742
Nawrath H, Blei J, Gegner R, Ludwig Ch, Zong X (1981) No stereospecific effects of the optical isomers of verapamil and D 600 on the heartln: Zanchetti A, Krikler OM (Hrsg.): Calcium antagonism in cardiovascular therapy. Excerpta medica, Amsterdam Oxford Princeton
Nimit Y, Skolnick P, Daly JW (1981) Adenosine and cyclic AMP in rat cerebral cortical slices: effects of adenosine uptake inhibitors and adenosine deaminase inhibitors. J Neurochem 36: 908–912
SiESJÖ BK (1978) Brain Energy Metabolism. John Wiley &Sons, Chichester New York Brisbane Toronto
SiesjÖ BK (1981) Cell damage in the brain: A speculative synthesis. J Cereb Blood Flow Metabol 1: 155
Verhaeghe RH (1977) Action of adenosine and adenine nucleotides on dog’s isolated veins. Am J Physiol 233: H114–H121
Ververken D, Van Veldhoven P, Proost C, Carton H, De Wulf H (1982) On the role of calcium ions in the regulation of glycogenolysis in mouse brain cortical slices. J Neurochem 38: 1286–1295
Vlahov V, Enzenross HG (1973) Einfluß der Ca ++-Ionen auf die Kontraktilität der glatten Muskulatur von Piagefäßen. Verh Dtsch Ges Kreislaufforsch 39: 129–132
Wahl M, Kuschinsky W (1976) The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline. Pflügers Arch 362: 55–59
Winn RH, Rubio R, Berne RM (1981) Brain adenosine concentration during hypoxia in rats Am J Physiol 241: H235–H242
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Kovách, A.G.B., Dora, E., Koller, A. (1983). Antihypoxischer Effekt von Gallopamil am Gehirn. In: Kaltenbach, M., Hopf, R. (eds) Gallopamil. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69073-0_7
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DOI: https://doi.org/10.1007/978-3-642-69073-0_7
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