Abstract
The introduction of radioimmunoassay (RIA) methods in the early 1960s permitted accurate measurement of individual pituitary hormones (Laron 1969) and the diagnosis of various types of pituitary insufficiency (Laron 1981a). It soon became possible not only to deflne a disease entity such as isolated human pituitary growth hormone (hGH) deficiency but also to diagnose partial defects and transitory deficiencies.
Keywords
- Growth Hormone
- Human Growth Hormone
- Isolate Growth Honnone Deficiency
- Pituitary Dwarfism
- Human Pituitary Growth Hormone
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Abramovici A, Josefsberg Z, Mimouni M, Liban E, Laron Z (1983) Histopathological features of the skin in hypopituitarism in Laron type dwarfism. Israel J Med Sei
Adam A, Josefsberg Z, Pertzelan A, Zadik Z, Chemke JM, Laron Z (1981) Occurrence of four types of growth hormone related dwarfism in Israeli communities. Eur J Pediatr 137: 35–39
Alcaniz JJ, Salto L, Barcelo B (1978) GH secretion in two siblings wiht Laron’s dwarfism: the effects of glucose, arginine, somatostatin and bromoeryptine. J Clin Endocrinol Metab 47: 453–456
Anderson WF, Fletcher JD (1980) Gene therapy in human beings: when is it ethical to begin? N Engl J Med 303: 1293–1296
Arad I, Laron Z (1979) Standards for upper/lower body segment ratio/sitting height — sub-ischial leg length from birth to 18 years in girls and boys. In: Proceedings of Ist International Congress of Auxology, Rome. Centro Auxologica Italiano di Piancavallo, Milan, pp 159-164
Carr B, Friesen HG (1976) Growth hormone and insulin binding to human liver J Endocrinol Metab 42: 484–493
Clemons RD, Costing G, Kogut MD (1976) Laron dwarfism: growth and immunore-active insulin following treatment with human growth hormone. J Pediatr 88: 427–433
Collado F, Martull MV, Torreblanca J, Fernandez A (1971) Enanismo familiar con niveles altos de hormona de crescimento ( GH) y falta de respuesta periferica a la hormona de crescimento humana exogena (hGH) y a la testosterona. Bol S Ped Madr 18: 7–16
Daughaday WH (1981) Growth hormone and the somatomedins. In: Daughaday WH (ed) Endocrine control of growth. Elsevier, North Holland, New York Oxford, pp 1–24
Daughaday WH, Laron Z, Pertzelan A, Heins JN (1969) Defective sulfation factor generation: a possible etiological link in dwarfism. Trans Assoc Am Physicians 82: 129–138
Eiders MJ, Garland JT, Daughaday A, Fisher DA, Whitney JE, Hughes ER (1973) Laron’s dwarfism: studies on the nature of the defect. J Pediatr 83: 253–263
Eshet R, Laron Z, Brown M, Arnon R (1973) Immunoreactive properties of the plasma hGH from patients with the Syndrome of familial dwarfism and high plasma IR-hGH. J Clin Endocrinol Metab 37: 819–821
Eshet R, Laron Z, Brown M, Arnon R (1974) Immunological behaviour of hGH from plasma of patients with familial dwarfism and high IR-hGH in a radioimmunoassay system using the cross reaction between hGH and HCS. Horm Metab Res 6: 80–81
Eshet R, Peleg S, Josefsberg Z, Laron Z (1981) Characterization of hGH from patients with LTD by a human liver radioreceptor assay (RRA) ( Abstr ). Pediatr Res 15: 89
Eshet R, Laron Z, Pertzelan A, Arnon R, Dintzman M (in press) Defect of hGH receptors in the liver of 2 patients with Laron type dwarfism. Isr J Med Sei
Frankel JJ, Laron Z (1968) Psychological aspects of pituitary insufficiency in children and adolescents with special reference to growth hormone. Isr J Med Sei 4:953–961
Frasier SD, Smith FG Jr (1966) Antibodies to human growth hormone. Development during therapy with human growth hormone. Am J Dis Child 112: 383–388
Galatzer A, Rosenblith E, Laron Z (1978) Psychological and rehabilitation aspects of short stature and delayed puberty. In: Gedda L, Parisi P (eds) Auxology: Human growth in health and disorder. Academic Press, London, pp 303 — 311
Golde DW, Bersch N, Kaplan SA, Rimoin DL, Li CH (1980) Peripheral unresponsiveness to human growth hormone in Laron dwarfism. N Engl J Med 303: 1156–1159
Goodman AD,Tanenbaum R, Rabinowitz D (1972) Existence of two forms of immunoreactive growth hormone in human plasma. J Clin Endocrinol Metab 35: 868–878
Jacobs LS, Sneid DS, Garland JT, Laron Z, Daughaday WH (1976) Receptor active growth hormone in Laron dwarfism. J Clin Endocrinol Metab 42: 403–406
Rastrup KW, Andersen H, Hanssen KF (1975) Increased immunoreactive plasma and urinary growth hormone in growth retardation with defective generation of somatomedin A ( Laron’s Syndrome ). Acta Paediatr Scand 64: 613–618
Kleine TO, Merten B, Meier HW, Nevo Z, Kowadlo Silbergeld A, Mamet R, Laron Z (1980) Effect of normal and pathological sera of patients with low serum somatomedin levels on prteoglycan glycosaminoglyean biosynthesis in two types of cartilage. In: Robert AM, Robert L (eds) Biochimie des tissue conjonctifs normaux et pathologiques. CNRS Editions, Paris, pp 173–175
Konfino R, Pertzelan A, Laron Z (1975) Cephalometric measurements of familial dwarfism and high plasma immunoreactive growth hormone. Am J Orthod 68: 196–201
Laron Z (1969) The hypothalamus and the pituitary gland (hypophysis). In: Hubble DW (ed) Paediatric endocrinology, Blackwell, Oxford, pp 35–111
Laron Z (1974) Syndrome of familial dwarfism and high plasma immunoreactive growth hormone. Isr J Med Sei 10: 1247–1253
Laron Z (1977) Syndrome of familial dwarfism and high plasma immunoreactive growth hormone (IR-hGH) — Laron type dwarfism. Paediatrician 6: 106–117
Laron Z (1981a) Clinical aspects of pituitary dwarfism and related conditions. In: Daughaday WH (ed) Endocrine control of growth. Elsevier, North Holland, New York, pp 175–205
Laron Z (1981b) Nutrition and growth factors with special emphasis on proteins. In: Beers RF, Bassett EG (eds) Nutritional factors: Modulating effects on metabolic Processes, Raven Press, New York, pp 337–354
Laron Z (1982) Somatomedin, insulin, growth hormone and growth. Isr J Med Sei 18: 823–829
Laron Z, Galatzer A (1980) Aspects of brain development in children and adolescents with pituitary growth hormone deficiency. In: De Wied D, Van Keep PA (eds) Hormones and the brain. MTP Press, Lancaster, pp 293–302
Laron Z, Karp M (1980) Carbohydrate metabolism in the Syndrome of familial and high plasma immunoreactive growth hormone (Laron type dwarfism). In: Podolsky S, Viswanathan M (eds) Secondary diabetes: The spectrum of the diabetic Syndrome. Raven Press, New York, pp 363–371
Laron Z, Pertzelan A, Mannheimer S (1966) Genetic pituitary dwarfism with high serum concentration of growth hormone. A new inborn error of metabolism? Isr J Med Sei 2: 152–155
Laron Z, Karp M, Dudek M, Kowadlo Silbergeld A, Harel D (1968a) A contribution to the fat mobilizing activity of human growth hormone. Helv Paediatr Acta 23: 37–44
Laron Z, Pertzelan A, Karp M (1968b) Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sei 4: 883–894
Laron Z, Pertzelan A, Karp M, Kowadlo Silbergeld A, Daughaday WH (1971) Administration of growth hormone to patients with familial dwarfism with high plasma immunoreactive growth hormone. Measurement of sulfation factor, metabolic and linear growth responses. J Clin Endocrinol Metab 33: 332–342
Laron Z, Karp M, Pertzelan A, Kauli R, Keret R, Doron M (1972) The Syndrome of familial dwarfism and high plasma immunoreactive human growth hormone (IR-hGH). In: Pecile A, Muller EE (eds) Growth and growth hormone. Exceprta Medica, Amsterdam, pp 458–482
Laron Z, Doron M, Josefsberg Z, Klonizky S, Weissman I (1974) Plasma glucagon response to arginine infusion in children with isolated hGH deficiency, panhypopituitarism and familial dwarfism and high plasma IR-hGH deficiency. In: Luft R, Yalow RS (eds) Radioimmunoassay: methodology and applications in physiology and in clinical studies. Horm Metab Res [Suppl] 5: 162–166
Laron Z, Pertzelan A, Karp M (1975) Glucose intolerance in children and young adults with dwarfism due to hGH deficiency and with the Syndrome of dwarfism and high plasma IR-hGH. In: Laron Z, Karp M (eds) Diabetes in juveniles, Modern Problems in pediatrics, vol 12. Karger, Basel London New York, pp 109–117
Laron Z, Pertzelan A, Doron M, Assa S, Keret R (1977) The effect of dihydrosomatostatin in dwarfism with high plasma immunoreactive growth hormone. Horm Metab Res 9: 338–339
Laron Z, Arad J, Gurewitch R, Grunebaum M, Dickerman Z (1980a) Age at first conscious ejaculation: a milestone in male puberty. Helv Paediatr Acta 35: 13–30
Laron Z, Kowadlo Silbergeld A, Eshet R, Pertzelan A (1980b) Growth hormone resistance. Ann Clin Res 12: 269–277
Laron Z, Sarel R, Pertzelan A (1980c) Puberty in Laron type dwarfism. Eur J Pediatr 134: 79–83
Martin JB (1983) Neuroendocrine regulation of growth hormone secretion. In: Laron Z, Butenandt O (eds) Evaluation of growth hormone secretion, pediatric and adolescent endoerinology, vol 12. Karger, Basel
McCoy EE, Bala RM (1978) Somatomedin deficiency (Laron type) dwarfism in Eskimo children ( Abstr. ). Clin Res 26: 845A
Merimee TJ, Hall J, Rabinowitz D, McKusick VA, Rimoin DL (1968) An unusual variety of endoerine dwarfism: subresponsiveness to growth hormone in a sexually mature dwarf. Lancet II: 191-193
Merimee TJ, Finberg SE, McKusick VA, Hall J (1970) Diabetes mellitus and sexual ateleiotic dwarfism: a comparative study. J Clin Invest 49: 1096–1102
Moses AC, Nissley SP, Passamani J, White RM (1979) Further characterization of growth hormone-dependent somatomedin-binding proteins in rat serum and demonstration of somatomedin binding proteins produced by rat liver cells in culture. Endoerinology 104: 536–546
Najjar SS, Khachadurian AK, Ilbawl MN, Blizzard RM (1971) Dwarfism with elevated levels of plasma growth hormone. N Engl J Med 284: 809–812
Nevo Z, Mimouni M, Laron Z (1977) Growth Parameters of cultured skin fibroblasts and growth promoting activity of sera from patients with growth disturbances ( Abstr. ). Isr J Med Sei 33: 1242
Pertzelan A, Adam A, Laron Z (1968) Genetic aspects of pituitary dwarfism due to absence or biological inactivity of growth hormone. Isr J Med Sei 4: 895–900
Pierson M, Malaprade D, Fortier G, Belleville F, Lasbennes A, Wuilbercq L (1978) Le nanisme familial de type Laron, deficit gentique primaire en somatomedine. Arch Fr Pediatr 35: 151–164
Pombo JLH, Lozano I, Ruiz-Valdepenas MP, Arrieta F, Rodrigues-Minon JL (1973) Enanismo familiar com niveles elevados de STH immunoreactive. Rev Clin Esp 131: 149–152
Posner BI, Kelly PA, Shin RPC, Frisen HG (1974) Studies of insulin, growth hormone and prolactin bin ding: tissue distribution, species Variation and characterization. Endocrinology 96: 521–531
Rappaport R, Czernichow P, Prevost C, Jullien M (1977) Retard de croissance avec somathoormone circulante elevee et incapacite ä generer la somatomedine (nanisme de type Laron). Ann Pediatr (Paris) 24: 63–67
Root AW (1972) Human pituitary growth hormone. Thomas, Springfield, III, p 31 Saldanha PH, Toledo SPA (1981) Famüial dwarfism with IR-GH: Report of two affected sibs with genetic and epidemiologic considerations. Hum Genet 59: 367–372
Salmon WD, Daughaday WH (1957) A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 49: 825–836
Schalch DS, Heinrich UE, Draznin B, Johnson CJ, Müler LL (1979) Role of the liver in regulating somatomedin activity; hormonal effects on the synthesis and release of insulin like growth factor and its carrier protein by the isolated perfused rat liver. Endocrinology 104: 1143–1151
Scharf A, Laron Z (1972) Skull changes in pituitary dwarfism and the Syndrome of familial dwarfism with high plasma immunoreactive growth hormone. A reontgenologic study. Horm Metab Res 4: 93–97
Schoenle E, Zapf J, Humbel RE, Froesch ER (1982) Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature 296: 252–253
Shurka E, Laron Z (1975) Adjustment and rehabilitation problems of children and adolescents with growth retardation. I. Familial dwarfism with high plasma immunoreactive human growth hormone. Isr J Med Sei 11: 352–357
Sneid DS, Jacobs LS, Weldon VV, Triveldi BL, Daughaday WH (1975) Radioreceptor inactive growth hormone associated with stimulated secretion in normal subjects. J Clin Endocrinol Metab 41: 471–474
Van den Brande JL, DuCaju MVL, Visser HKA, Schopman W, Hacheng WHL, Degenhart HJ (1974) Primary somatomedin deficiency. Arch Dis Child 49: 297–304
Zaizov R, Laron Z (1966) Body length and weight at birth and one year of age in different communities in Israel. Acta Paediatr Scand 55: 524–528
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Laron, Z. (1984). Laron-Type Dwarfism (Hereditary Somatomedin Deficiency): A Review. In: Frick, P., von Harnack, GA., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics, vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69070-9_3
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DOI: https://doi.org/10.1007/978-3-642-69070-9_3
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