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Prognosis of Coronary Heart Disease Progression of Coronary Arteriosclerosis pp 223–230Cite as

Oral Anticoagulants and/or Aspirin

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Abstract

Important progress has been made during the past few years in the understanding of putative successes and failures of oral anticoagulation (OAC) in general, and in the secondary prevention of myocardial infarction in particular. Not only did the conception of thrombotic pathogenesis of the transmural type of myocardial infarction revive after successful removal of acute coronary obstruction by the use of streptokinase, a thrombolytic agent (Loeliger 1981); the results of the Dutch Sixty-Plus Reinfarction Study, which showed a significantly better prognosis for patients given continued oral anticoagulant therapy (Sixty-Plus Reinfarction Study Research Group 1980), reopened the discussion about oral anticoagulants in myocardial infarction (Mitchell 1981). It became clear that strict adherence to a well-defined therapeutic range (Poller 1982), therapeutic quality control (Duxbury 1982), and standardization of the prothrombin time (Loeliger and Lewis 1982) were essential for successful anticoagulation; in their absence such treatment is doomed to failure (Loeliger 1981).

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Author information

Authors and Affiliations

  1. Interne Geneeskunde, Academisch Ziekenhuis, Leiden, The Netherlands

    E. A. Loeliger

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  1. E. A. Loeliger
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Editor information

Editors and Affiliations

  1. Benedikt Kreutz Rehabilitationszentrum für Herz- und Kreislaufkranke, Bad Krozingen e.V. Südring 15, 7812, Bad Krozingen, Germany

    H. Roskamm

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© 1983 Spriger-Verlag Berlin Heidelberg

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Loeliger, E.A. (1983). Oral Anticoagulants and/or Aspirin. In: Roskamm, H. (eds) Prognosis of Coronary Heart Disease Progression of Coronary Arteriosclerosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69052-5_26

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  • DOI: https://doi.org/10.1007/978-3-642-69052-5_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69054-9

  • Online ISBN: 978-3-642-69052-5

  • eBook Packages: Springer Book Archive

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