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Oral Anticoagulants and/or Aspirin

  • E. A. Loeliger
Conference paper

Abstract

Important progress has been made during the past few years in the understanding of putative successes and failures of oral anticoagulation (OAC) in general, and in the secondary prevention of myocardial infarction in particular. Not only did the conception of thrombotic pathogenesis of the transmural type of myocardial infarction revive after successful removal of acute coronary obstruction by the use of streptokinase, a thrombolytic agent (Loeliger 1981); the results of the Dutch Sixty-Plus Reinfarction Study, which showed a significantly better prognosis for patients given continued oral anticoagulant therapy (Sixty-Plus Reinfarction Study Research Group 1980), reopened the discussion about oral anticoagulants in myocardial infarction (Mitchell 1981). It became clear that strict adherence to a well-defined therapeutic range (Poller 1982), therapeutic quality control (Duxbury 1982), and standardization of the prothrombin time (Loeliger and Lewis 1982) were essential for successful anticoagulation; in their absence such treatment is doomed to failure (Loeliger 1981).

Keywords

Prothrombin Time Oral Anticoagulant Oral Anticoagulation Oral Anticoagulant Therapy Recurrent Myocardial Infarction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Spriger-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • E. A. Loeliger
    • 1
  1. 1.Interne GeneeskundeAcademisch ZiekenhuisLeidenThe Netherlands

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