Die zellulären und humoralen Abwehrmechanismen des Respirationstraktes und ihre prophylaktische oder therapeutische Beeinflussung

  • H.-G. Manke
  • J. R. Kalden
Conference paper

Zusammenfassung

Die Lunge, jahrzehntelang bezüglich ihres Stoffwechsels, ihrer endokrinen Funktionen und ihrer Abwehrsysteme ein fast unbekanntes Organ, ist in den letzten Jahren mehr ins Blickfeld der klinischen Forschung gerückt.

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Literatur

  1. 1.
    Ahmed T, Greenblatt DW, Birch S, Marchette B, Wanner A (1981) Abnormal mucociliary transport in allergic patients with antigen-induced bronchospasm: Role of slow reacting substance of anaphylaxis. Am Rev Respir Dis 124: 110–114PubMedGoogle Scholar
  2. 2.
    Beck CS, Heiner DC (1981) Selective immunoglobulin G4 deficiency and recurrent infections of the respiratory tract. Am Rev Respir Dis 124: 94–96PubMedGoogle Scholar
  3. 3.
    Bell DY, Hasemann JA, Spock A, McLennan G, Hook GER (1981) Plasma proteins of the bronchoalveolar surface of the lungs of smokers and nonsmokers. Am Rev Respir Dis 124: 72–79PubMedGoogle Scholar
  4. 4.
    Biddison WE, Shaw S, Nelson DL (1979) Virus specificity of human influenza virus-immune cytotoxic T cells. J Immunol 22: 660–664Google Scholar
  5. 5.
    Bienenstock J, Johnston N, Perey DYE (1973) Bronchial lymphoid tissue. II. Functional characteristics. Lab Invest 28: 693–698PubMedGoogle Scholar
  6. 6.
    Brain JD (1980) Nonimmunologic defense mechanisms. In: Fishman AP (ed) Pulmonary disease and disorders. New York, pp 633–639Google Scholar
  7. 7.
    Brain JD, Sorokin SP, Godleski JJ (1977) Quantification, origin and fate of pulmonary macrophages. In: Brain JD, Proctor DF, Reid LM (eds) Respiratory defense mechanisms. Dekker, New York (Lung biology in health and disease, vol 5/II, pp 849–892 )Google Scholar
  8. 8.
    Brown DT, Marriott C, Beeson MF, Barrett-Bee K (1981) Isolation and partial characterization of a rheologically active glycoprotein fraction from pooled human sputum. Am Rev Respir Dis 124: 285–291PubMedGoogle Scholar
  9. 9.
    Church JA, Isaacs H, Saxan A, Keens TG, Richards W (1981) Lymphoid interstitial pulmonitis and hypogammaglobulinemia in children. Am Rev Respir Dis 124: 491–496PubMedGoogle Scholar
  10. 10.
    Coles SJ, Said SJ, Reid LM (1981) Inhibition by vasoactive intestinal peptide of glycoconjugate and lysozyme secretion by human airways in vitro. Am Rev Respir Dis 124: 531–536PubMedGoogle Scholar
  11. 11.
    Corkey CWB, Levison H, Turner JAP (1981) The immotile cilia syndrome. (A longitudinal survey). Am Rev Respir Dis 124: 544–548PubMedGoogle Scholar
  12. 12.
    Daniele RP (1980) Immuno defenses of the lung. In: Fishman AP (ed) Pulmonary disease and disorders. McGraw-Hill, New York, pp 624–632Google Scholar
  13. 13.
    Daniele RP, Altose MD, Rowlands DT Jr (1975) Immunocompetent cells from the lower respiratory tract of natural human lungs. J Clin Invest 56: 986–995PubMedCrossRefGoogle Scholar
  14. 14.
    Daniele RP, Dauber JH, Altose MD, Rowlands DT Jr, Gorenberg DJ (1977) Lymphocyte studies in asymptomatic cigarette smokers. A comparison between lung and peripheral blood. Am Rev Respir Dis 116: 997–1005Google Scholar
  15. 15.
    David JR, Renold HG (1976) Macrophage activation by lymphocyte mediators and studies on the interaction of makrophage inhibitory factor (MIF). In: Nelson DS (ed) Immunobiology of the macrophage. New York, pp 428–461Google Scholar
  16. 16.
    Dufano MJ, Luk CK, Beckage M, Wooten O(1981) Ciliary beat frequency in human respiratory explants. Am Rev Respir Dis 123: 139–140Google Scholar
  17. 17.
    Duswald KH, Müller K, Seifert J, Ring J (1979) Wirksamkeit von i.v. Grammaglobulin gegen bakterielle Infektionen chirurgischer Patienten. Ergebnisse einer kontrollierten, randomisierten klinischen Studie. MMW 122: 832–836Google Scholar
  18. 18.
    Evans R, Alexander P (1976) Mechanisms of extracellular killing of nucleated mammalian cells by macrophages. In: Nelson DS (ed) Immunobiology of the macrophage, New York, pp 536–576Google Scholar
  19. 19.
    Feinstein D, Franklin EC (1966) Two antigenically distinguishable subclasses of human A myeloma proteins differing in their heavy chains. Nature 212: 1496–1498PubMedCrossRefGoogle Scholar
  20. 20.
    Green GM, Jakob GJ, Low RB, Davis GS (1977) Defense mechanisms of the respiratory membrane. Am Rev Respir Dis 115: 479–514PubMedGoogle Scholar
  21. 21.
    Hammer JA, Rannels DE (1981) Effects of halothaneon protein synthesis and degradation in rabbit pulmonary macrophages. Am Rev Respir Dis 124: 50–55PubMedGoogle Scholar
  22. 22.
    Hay FC, Torrigiani G, Roitt IM (1972) The binding of human IgG subclasses to human monocytes. Eur J Immunol 2: 257PubMedCrossRefGoogle Scholar
  23. 23.
    Hitzig WH (1977) Das Antikörpermangel-Syndrom. Schweiz Med Wochenschr 107: 1729–1736Google Scholar
  24. 24.
    Hof DG, Repine JE, Giebnik GS, Hoidal JR (1981) Production of opsonins that facilitate phagocytosis of streptococcus pneumoniae by human alveolar macrophages or neutrophils after vaccination with pneumococcal polysaccharide. Am Rev Respir Dis 124: 193–195PubMedGoogle Scholar
  25. 25.
    Huber H, Douglas SD, Nusbacher I, Kochwa S, Rosenfeld RE (1971) IgG subclass specificity of human monocyte receptor site. Nature 229: 419–420PubMedCrossRefGoogle Scholar
  26. 26.
    Jakob GJ, Warr GA (1981) Immune-enhanced phagocytic dysfunction in pulmonary macrophages infected with parainfluenca 1 ( Sendai) virus. Am Rev Respir Dis 124: 575–581Google Scholar
  27. 27.
    Kalden JR (1979) Physiologische Grundlagen der Immunglobulintherapie. Biotest Mitt 37: 21–29Google Scholar
  28. 28.
    Kalden JR (1982) Immuntherapeutische Möglichkeiten bei Vorbeugung und Behandlung von Infektionskrankheiten. In: Kalden JR, König UD (Hrsg) Blutkomponenten und Infektionskrankheiten. Springer, Berlin Heidelberg New York, S 20–27Google Scholar
  29. 29.
    Kaltreider HB, Chan MK (1976) The class-specific immunoglobulin composition of fluids obtained from various levels of the canine respiratory tract. J Immunol 116: 423–429PubMedGoogle Scholar
  30. 30.
    Keller R (1976) Cytostatic and cytocidal effects of activated macrophages. In: Nelson DS (ed) Immunobiology of the macrophage. New York, pp 487–508Google Scholar
  31. 31.
    Kunkel HG, Prendergast RA (1963) Subgroups of y A immunoglobulins. Proc Soc Exp Biol Med 122: 910–913Google Scholar
  32. 32.
    Laviolette M, Chang J, Newcomb DS (1981) Human alveolar macrophages: A lesion in arachidonic acid metabolism in cigarette smokers. Am Rev Respir Dis 124: 397–401PubMedGoogle Scholar
  33. 33.
    Macklin CC (1955) Pulmonary sumps, dust accumulations, alveolar fluid and lymph vessels. Acta Anat (Basel) 23: 1–33CrossRefGoogle Scholar
  34. 34.
    Manke HG, et al. (im Druck) Einfluß von IgM-angereicherten Serumkonserven auf die periblastomatöse Pneumonie bei Patienten mit Bronchialkarzinom.Google Scholar
  35. 35.
    Morell A, Skvaril F (1980) Strukur und biologische Eigenschaften von Immunglobulinen und y-Globulin-Präparaten. Schweiz Med Wochenschr 110: 80–85PubMedGoogle Scholar
  36. 36.
    Oxelius V-A, Berkel AI, Handon LA (1982) IgG 2 deficiency in ataxia-teleangiectasia. N Engl J Med 306: 515–517PubMedCrossRefGoogle Scholar
  37. 37.
    Râcz P, Tenner-Râcz K, Myrvik QN, Fainter LK (1977) Functional architecture of bronchial associated lymphoid tissue and lymphoepithelium in pulmonary cell-mediated reactions in the rabbit. J Reticuloendothel Soc 22: 59–83PubMedGoogle Scholar
  38. 38.
    Raff MC (1973) T and B lymphocytes and the immune response. Nature 242: 19–23PubMedCrossRefGoogle Scholar
  39. 39.
    Reynolds HJ, Kazmierowski JA, Newball HH (1975) Specificity of opsonic antibodies to enhance phagocytosis of pseudomonas aeroguinosa by human alveolar macrophages. J Clin Invest 56: 376–385PubMedCrossRefGoogle Scholar
  40. 40.
    Ring J, Duswald KH (1980) Probleme der intravenösen Gammaglobulintherapie. Klin Wochenschr 58: 797–809PubMedCrossRefGoogle Scholar
  41. 41.
    Robertson J, Caldwell JR, Castle JR, Waldman RH (1976) Evidence for the presence of components of the alternate (properdin) pathway of complement activation in respiratory secretions. J Immunol 117: 900–903PubMedGoogle Scholar
  42. 42.
    Römer J, Morgenthaler J-J, Scherz R, Skvaril F (1982) Characterization of various immunoglobulin preparations for intravenous application. I. Protein composition and antibody content. Vox Sang 42: 62–73PubMedGoogle Scholar
  43. 43.
    Römer J, Späth PJ, Skvaril F, Nydegger UE (1982) Characterization of various immunoglobulin preparations for intravenous application. Vox Sang 42: 74–80PubMedGoogle Scholar
  44. 44.
    Rossman CM, Forrest JB, Lee RMKW, Newhouse MT (1980) The dyskinetic cilia syndrome. Ciliary motility in the immotile cilia syndrome. Chest 78: 580–582PubMedCrossRefGoogle Scholar
  45. 45.
    Ruthland J, Griffin WM, Cole PJ (1982) Human ciliary beat frequency in epithelium from intrathoracic and extrathoracic airways. Am Rev Respir Dis 125: 100–105Google Scholar
  46. 46.
    Sidiropoulos D, Böhme U, Murait G von, Morell A, Barandun S (1981) Immunoglobulin-substitution bei der Behandlung neonataler Sepsis. Schweiz Med Wochenschr 111: 1649–1655PubMedGoogle Scholar
  47. 47.
    Spiegelberg HL (1974) Biological activities of immunoglobulins of different classes and subclasses. Adv Immunol 19: 259PubMedCrossRefGoogle Scholar
  48. 46.
    Strober W, Krakauer R, Klaeveman HC, Reynolds HY, Nelson DL (1976) Secretory com- ponent deficiency. A disorder of the IgA immune system. N Engl J Med 294: 351–356PubMedCrossRefGoogle Scholar
  49. 49.
    Sturgess JM, Chao J, Wong J, Aspin N, Turner JAP (1979) Cilia with defective radial spokes. A cause for human respiratory disease. N Engl J Med 300: 53–56PubMedCrossRefGoogle Scholar
  50. 50.
    Sturgess JM, Chao J, Turner JAP (1980) Transposition of ciliary microtubules. Another cause for the immotile cilia syndrome N Engl J Med 303: 318–322PubMedCrossRefGoogle Scholar
  51. 51.
    Thomas WR, Holf PG, Keast D (1972) Cellular immunity in mice chronically exposed to fresh cigarette smoke. Arch Environ Health 27: 372–375Google Scholar
  52. 52.
    Vaerman, JP, Heremans JF (1966) Subclasses of human immunoglobulin A based on differences in the alpha polypeptide chains. Science 153: 647–649PubMedCrossRefGoogle Scholar
  53. 53.
    Wilde CE, Koshland ME (1973) Molecular size and shape of the J chain from polymeric immunoglobulin. Biochemistry 12: 3218–3224Google Scholar
  54. 54.
    Yasmeen D, Ellersen JF, Dorrington KJ, Painter RH (1973) Evidence for the domain hypothesis: Locations of the site of cytophilic activity toward guinea pig macrophages in the CH3 homology region of human immunoglobulin G. J Immunol 110: 1706–1709PubMedGoogle Scholar
  55. 55.
    Yount WJ (1982) IgG2 deficiency and ataxia-telangiectasia. N Engl J Med 306: 541–543PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1983

Authors and Affiliations

  • H.-G. Manke
  • J. R. Kalden

There are no affiliations available

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