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Glucagon II pp 645–666Cite as

Glucagon in the Diagnosis and Treatment of Hypoglycaemia

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 2))

Abstract

Two of glucagon’s many pharmacological properties are utilised clinically for the diagnosis and treatment of hypoglycaemia. They are its ability: (1) to raise the blood glucose concentration by increasing hepatic glycogenolysis; and (2) to stimulate insulin secretion by direct action on pancreatic B-cells. Though still widely used for the treatment of acute episodes of iatrogenic hypoglycaemia in insulin-dependent subjects, the advent of more specific and more effective treatments has reduced almost to zero the usefulness of glucagon as a therapy for chronic hypoglycaemia. Similarly, the availability of improved diagnostic procedures for hyperinsulinism, glycogen storage disease and the various endocrinopathies associated with, and causative of, spontaneous hypoglycaemia has reduced the usefulness of glucagon in the differential diagnosis of these disorders to that of an adjunct rather than a key.

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Authors
  1. V. Marks
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Editors and Affiliations

  1. University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Médecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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© 1983 Springer-Verlag Berlin Heidelberg

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Marks, V. (1983). Glucagon in the Diagnosis and Treatment of Hypoglycaemia. In: Lefebvre, P.J. (eds) Glucagon II. Handbook of Experimental Pharmacology, vol 66 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69019-8_33

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  • DOI: https://doi.org/10.1007/978-3-642-69019-8_33

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