Abstract
It has been speculated that small increments of insulin in the portal blood, counterbalanced by small increases in glucagon, could result in an enhanced protein anabolic effect with minimal shifts in glucose homeostasis. Such a hypothesis makes it reasonable to postulate that glucagon itself might be under pituitary control (see also Chap. 29).
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References
Adamson, V., (1975) Insulin-like and diabetogenic actions of human growth hormone in man. PhD dissertation, University of Stockholm, Stockholm
Blackard, WG., Andrews, SS., Lazarus, EJ., (1973) Effect of growth hormone deficiency on glucagon secretion. Proc Soc Exp Biol Med 143: 1042–1044
Bornstein, J., Reid, E., Young, FG., (1951) The hyperglycemic action of blood from animals treated with growth hormone. Nature 168: 903–905
Cain, JP., Williams, GH., Dluhy, RD., (1970) Glucagon stimulation of human growth hormone. J Clin Endocrinol Metab 31: 222–224
Cerasi, E., Luft, R., (1964) Insulin response to glucose loading in acromegaly. Lancet 2: 769–771
Cremer, GM., Molnar, GD., Moxness, KE., Sheps, SG., Maher, FT., Jones, JD., (1968) Hormonal and biochemical response to glucagon in patients with pheochromocytoma and in control subjects. Proc Mayo Clin 43: 161–176
Daughaday, WH., Kipnis, DM., (1966) The growth promoting and insulin actions of somatotropin. Recent Prog Horm Res 22: 49–99
Eddy, RL., Jones, AL., Hirsch, RM., (1970) Effect of exogenous glucagon on pituitary polypeptide hormone release. Metabolism 19: 904–911
Ellkeles, RS., Wright, AD., Lowy, C., Frazer, TR., (1969) Serum insulin in acromegaly. Lancet 2: 615–618
Foà, PP., Magid, EB., Glassman, MD., Weinstein, HR., (1953) Anterior pituitary growth hormone and pancreatic secretion of glucagon. Proc Soc Exp Biol Med 83: 758–761
Farmer, RW., Pellizari, ED., Fabre, LF., Nonaka, K., Sugase, T., Foà, PP., (1971) Failure of growth hormone to stimulate glucagon secretion. Proc Soc Exp Biol Med 138: 491–493
Frohman, LA., MacGillivray, MH., Aceto, T. Jr., (1971) Acute effects of human growth hormone in normal and growth hormone deficient subjects. J Clin Endocrinol Metab 27: 561–567
Goldfine, ID., Kirstens, L., Lawrence, AM., (1972) Excessive glucagon response to arginine in active acromegaly. Horm Metab Res 4: 97–100
Hainer, V., Urbanek, J., Malec, B., Krejcik, L., (1981) The effect of TRH, cyproheptadine and pimozide on the growth hormone response to intramuscular glucagon. Horm Metab Res 13: 451–453
Ketterer, B., Randle, PJ., Young, FG., (1957) The pituitary growth hormone and metabolic processes. Ergeb Physiol Biol Chem Exp Pharmakol 49: 121–211
Kühl, C., Jensen, SL., Nielson, OV., Hoist, J J., (1976) Influence of basal plasma glucose concentration on the glucagon response to arginine. Scand J Gastroenterol [Suppl 37] 11: 53–56
Laron, Z., Mimoun, M., Josephberg, Z., Zadik, Z., Doron, M., (1977) The effect of growth hormone deficiency on the insulin response to glucagon after oral glucose loading. Diabetologia 13: 447–450
Larson, BA., Williams, TL., Lewis, VJ., Vanderloon, WP., (1978) Insulin secretion from pancreatic islets: effect of growth hormone and related proteins. Diabetologia 15: 129–132
Merimee, TJ., Rabin, D., (1973) A survey of growth hormone secretion and action. Metabolism 22: 1235–1251
Merimee, TJ., Burgess, J A., Rabinowitz, D., (1969) Influence of growth hormone on insulin secretion: studies of growth hormone deficient patients. Diabetes 16: 478–482
Mitchell, ML., Byrne, M J., Silver, J., (1969) Growth hormone release by glucagon. Lancet 1: 289–290
Mitchell, ML., Byrne, M J., Sanchez, Y., Sawin, CT., (1970) Detection of growth hormone deficiency. The glucagon stimulation test. N Engl J Med 282: 539–541
Mitchell, ML., Suvunrungsi, P., Sawin, CT., (1971) Effect of propanolol on the serum growth hormone response to glucagon. J Clin Endocrinol Metab 32: 470–475
Parks, JS., Amrhei, J A., Vaidya, V., Moshang, T., Bogiovanni, AM., (1973) Growth hormone responses to propanolol-glucagon stimulation: a comparison with other tests of growth hormone reserve. J Clin Endocrinol Metab 37: 85–92
Seino, Y., Taminato, T., Goto, Y., (1978 a) Growth hormone modulation of arginine-induced glucagon release: studies of isolated growth hormone deficiency and acromegaly. Clin Endocrinol (Oxf) 9: 563–570
Seino, Y., Taminato, T., Goto, Y., Inoue, Y., Kadowaki, S., Mari, K., Imura, H., (1978 b) Acromegaly: insensitivity of pancreatic alpha cell to hyperglycemia. Clin Endocrinol (Oxf) 9: 577–581
Sirek, A., Vranic, M., Sirek, OV., Vigas, M., Policova, Z., (1979) Effect of growth hormone on acute glucagon and insulin release. Am J Physiol 237: E107–E112
Sizonenko, P., Rabinowitz, A., Schneider, P., Paunier, L., Wollheim, CB., Zahnd, G., (1977) Plasma growth hormone, insulin, and glucagon responses to arginine infusion. Pediatr Res 9: 733–738
Tai, TY., Pek, S., (1976) Direct stimulation by growth hormone of glucagon and insulin release from isolated rat pancreas. Endocrinology 99: 669–677
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Merimee, T.J. (1983). Glucagon and Growth Hormone. In: Lefebvre, P.J. (eds) Glucagon II. Handbook of Experimental Pharmacology, vol 66 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69019-8_30
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DOI: https://doi.org/10.1007/978-3-642-69019-8_30
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