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Influence of Glucagon on Water and Electrolyte Metabolism

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Glucagon II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 2))

Abstract

Since the original reports of Staub et al. (1956, 1957) demonstrating that the injection of glucagon induced a strong diuretic effect in dogs, with an enhancement in renal excretion of sodium, chloride, phosphate, and potassium, several studies have been devoted to the possible role of glucagon in the regulation of water and electrolyte balance. Despite numerous investigations in this field, it still remains uncertain whether under physiologic conditions glucagon really plays a role in the maintenance of salt and water homeostasis. It has nevertheless been convincingly demonstrated that in some ketogenic states associated with insulinopenia, such as starvation or uncontrolled insulin-dependent diabetes, the increase in plasma glucagon levels promotes salt and water depletion.

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Authors
  1. J. Kolanowski
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Editors and Affiliations

  1. University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Médecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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© 1983 Springer-Verlag Berlin Heidelberg

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Kolanowski, J. (1983). Influence of Glucagon on Water and Electrolyte Metabolism. In: Lefebvre, P.J. (eds) Glucagon II. Handbook of Experimental Pharmacology, vol 66 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69019-8_28

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  • DOI: https://doi.org/10.1007/978-3-642-69019-8_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69021-1

  • Online ISBN: 978-3-642-69019-8

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