Skip to main content

Glucagon in Obesity

  • Chapter
Glucagon II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 2))

Abstract

Glucagon is capable of influencing many pathways of lipid metabolism (see Chap. 17, 19, 20, 25, 46) and although some uncertainty remains about the importance of glucagon in the regulation of lipid metabolism under physiologic circumstances in humans (Schade et al. 1979; Müller et al. 1977; Schade and Eaton 1976; Gerich et al. 1976; Pozefsky et al. 1976; Andrews et al. 1975; Liljenquist et al. 1974; Sherwin et al. 1976), glucagon’s potential influence has been sufficiently conspicuous to justify several investigations of its possible role in human and experimental obesity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aguilar-Parada E, Eisentraut AM, Unger RH (1969) Effects of starvation on plasma pancreatic glucagon in normal man. Diabetes 18: 717–723

    Google Scholar 

  • Andrews as, Lopez-S A, Blackard wg (1975) effect of lipids on glucagon secretion in man. Metabolism 24: 35–44

    Google Scholar 

  • Arky RA, Finger M, Veverbrants E, Braun AP (1970) Glucose And Insulin Response To Intravenous Glucagon During Starvation. Am J Clin Nutr 23: 691–695

    CAS  Google Scholar 

  • Assimacopoulos-Jeannet F, Jeanrenaud B (1976) The hormonal and metabolic basis of experimental obesity. Clin Endocrinol Metab 5: 337–365

    Article  PubMed  CAS  Google Scholar 

  • Atkinson RL, Dahms WT, Bray GA, Sperling MA (1981) adrenergic modulation of glucagon and insulin secretion in obese and lean humans. Horm Metab Res 13: 249–253

    Google Scholar 

  • Barry RE, Barisch J, Bray A, Sperling MA, Morin RJ, Benfield J (1977) Intestinal adaption after jejunoileal bypass in man. Am J Clin Nutr 30: 32–42

    PubMed  CAS  Google Scholar 

  • Beck-Nielsen H (1980) Insulin receptors in man. the monocyte as model for insulin receptor studies. thesis, laegeforeningens, copenhagen

    Google Scholar 

  • Besterman HS, Sarson DL, Blackburn HM, Cleary J, Pilkington Tre, Bloom SR (1978) The gut hormone profile in morbid obesity and following jejunoileal bypass. Scand J Gastroenterol 13 [SUPPL 49]: 15

    Google Scholar 

  • Bobbioni E, Coscelli C (1980) Portal Levels of Glucagon and Insulin In Vmh-Lesioned Rats. Horm Metab Res 12: 480–481

    Article  PubMed  CAS  Google Scholar 

  • Böttger I, Dobbs R, Faloona GR, Unger RH (1973) the effects of triglyceride absorption upon glucagon, insulin, and gut glucagon like immunoreactivity. J Clin Invest 52: 2532–2541

    Google Scholar 

  • Bray GA, York DA (1971) Genetically transmitted obesity in rodents. Physiol Rev 51: 598–646

    PubMed  CAS  Google Scholar 

  • Brobeck JR (1974) Mechanism of the development of obesity in animals with hypothalamic lesions. Physiol Rev 26: 541–559

    Google Scholar 

  • Broer Y, Freychet P, Rosselin G (1977) Insulin and glucagon receptor interactions in the genetically obese Zucker rat: studies of hormone binding and glucagon stimulated cyclic AMP levels in isolated hepatocytes. Endocrinology 101: 236–249

    Article  PubMed  CAS  Google Scholar 

  • Bryce GF, Johnson PR, Sullivan AC, Stern JS (1977) Insulin and glucagon plasma levels and pancreatic release in the genetically obese Zucker rat. Horm Metab Res 9: 366–370

    Article  PubMed  CAS  Google Scholar 

  • Chang K-J, Huang D, Cuatrecasas P (1975) The defect in insulin receptors in obesehyper glycemic mice: a probable accompaniment of more generalized alterations in membrane glycoproteins. Biochem Biophys Res Commun 64: 566–573

    Article  PubMed  CAS  Google Scholar 

  • Chikamori K, Nishimura N, Suehiro F, Sato K, Mori H, Saito S (1980) Alterations in glucagon secretion in obese rats with hypothalamic lesions. Horm Metab Res 12: 56–59

    Article  PubMed  CAS  Google Scholar 

  • Christiansen J, Bech A, Fahrenkrug J, Hoist JJ, Lauritsen K, Moody AJ, Schaffalitzky de Muckadell O (1979) Fat-induced jejunal inhibition of gastric acid secretion and release of pancreatic glucagon, gastric inhibitory polypeptide, and vasoactive intestinal polypeptide in man. Scand J Gastroenterol 14: 161–166

    Article  PubMed  CAS  Google Scholar 

  • Conlon JM, Murphy RF, Buchanan KD (1979) Physicochemical and biological properties of glucagon-like polypeptides from porcine colon. Biochim Biophys Acta 577: 229–240

    PubMed  CAS  Google Scholar 

  • De Santis RA, Gorenstein T, Livingston JN, Lockwood DH (1974) Role of phosphodiesterase in glucagon resistance of large adipocytes. J Lipid Res 15: 33–38

    PubMed  Google Scholar 

  • Eaton RP, Conway M, Schade DS (1976) Endogenous glucagon regulation in genetically hyperlipemic obese rats. Am J Physiol 230: 1336–1341

    PubMed  CAS  Google Scholar 

  • Falluca F, Menzinger G, Gambardella S, Tamburrano S, Andreani D (1975) Glucagon, insulin and growth hormone response in obese women. Acta Diabetol Lat 12: 239–243

    Article  Google Scholar 

  • Felig P, Wahren J, Hendler R, Brundin T (1974) Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest 53: 582–590

    Article  PubMed  CAS  Google Scholar 

  • Findlay J A, Rookledge KA, Beloff-Chain H, Lever JD (1973) A combined biochemical and histological study of the islets of Langerhans in the genetically obese hyperglycaemic mouse and in the lean mouse, including observations on the effects of Streptozotocin treatment. J Endocrinol 56: 571–583

    CAS  Google Scholar 

  • Fisher M, Sherwin RS, Hendler R, Felig P (1976) Kinetics of glucagon in man: effects of starvation. Proc Natl Acad Sci USA 73: 1735–1739

    Article  PubMed  CAS  Google Scholar 

  • Galbo H, Hoist JJ, Christensen NJ (1975) Glucagon and plasma catecholamine responses to graded and prolonged exercise in man. J Appl Physiol 38: 70–75

    PubMed  CAS  Google Scholar 

  • Galbo H, Richter EA, Hilsted J, Hoist J J, Christensen NJ, Henriksson J (1977) Hormonal regulation during prolonged exercise. Ann NY Acad Sci 301: 72–80

    Article  PubMed  CAS  Google Scholar 

  • Galbo H, Hoist JJ, Christensen NJ (1979) The effect of different diets and of insulin on the hormonal response to prolonged exercise. Acta Physiol Scand 107: 19–32

    Article  PubMed  CAS  Google Scholar 

  • Garlaschi C, di Natale B, del Guercio MJ, Caccamo A, Gargantini L, Chiumello G (1975) Effect of physical exercise on secretion of growth hormone, glucagon, and Cortisol in obese and diabetic children. Diabetes 24: 758–761

    Article  PubMed  CAS  Google Scholar 

  • Gerich JE, Schneider Y, Langlois M, Karam JH, Noacco C (1974) Glucagon secretion in obesity. Clin Res 22: 190A

    Google Scholar 

  • Gerich JE, Lorenzi M, Bier DM, Tsalikian E, Schneider V, Karam JH, Forsham PH (1976) Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. J Clin Invest 57: 875–884

    Article  PubMed  CAS  Google Scholar 

  • Glass AR, Burman KD, Dahms W, Boehm TM (1981) Endocrine function in human obesity. Metabolism 30: 89–104

    Article  PubMed  CAS  Google Scholar 

  • Goschke H (1977) Mechanism of glucose intolerance during fasting: differences between lean and obese subjects. Metabolism 26: 1147–1153

    Article  PubMed  CAS  Google Scholar 

  • Gold RM, Sawchenko PE, DeLuca C, Alexander J, Eng R (1980) Vagal mediation of hypothalamic obesity but not of supermarket dietary obesity. Am J Physiol 238: R447–R453

    PubMed  CAS  Google Scholar 

  • Gossain VV, Matute ML, Kalkhoff RK (1974) Relative influence of obesity and diabetes on plasma alpha-cell glucagon. J Clin Endocrinol Metab 38: 238–243

    Article  PubMed  CAS  Google Scholar 

  • Gutmann RA, Fink G, Voyles N, Selawry H, Penhos JC, Lepp A, Recant L (1973) Specific biologic effects of intestinal glucagon-like materials. J Clin Invest 52: 1165–1175

    Article  Google Scholar 

  • Glucagon in Obesity Hayek A, Woodside W (1979) Correlation between morphology and function in isolated islets of the Zucker rat. Diabetes 28: 565–569

    Article  Google Scholar 

  • Hoist J J, Christiansen J, Kohl C (1976) The enteroglucagon response to intrajejunal infusion of glucose, triglycerides, and sodium chloride, and its relation to jejunal inhibition of gastric acid secretion in man. Scand J Gastroenterol 11: 297–304

    Google Scholar 

  • Hoist JJ, Sorensen TIA, Andersen AN, Stadil F, Andersen B, Lauritsen KB, Klein HC (1979) Plasma enteroglucagon after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio. Scand J Gastroenterol 14: 205–207

    Article  Google Scholar 

  • Hoist JJ, Schwartz TW, Lovgren NA, Pedersen O, Beck-Nielsen H (1983) Diurnal profile of pancreatic polypeptide, pancreatic glucagon, gut glucagon and insulin in human morbid obesity. Int. J Obesity (in press)

    Google Scholar 

  • Horigome K, Ohneda A, Maruhama Y, Abe R, Kai Y (1977) Heterogeneity of extractable gut glucagon like immunoreactivity (GLI) and its lipolytic activity. Horm Metab Res 9: 370–374

    Article  PubMed  CAS  Google Scholar 

  • Ingalls AM, Dickie MM, Snell GP (1950) Obese, new mutation in the mouse. J Hered 41: 317–318

    PubMed  CAS  Google Scholar 

  • Inoue S, Bray GA (1979) An autonomic hypothesis for hypothalamic obesity. Life Sci 25: 561–566

    Article  PubMed  CAS  Google Scholar 

  • Inoue S, Campfield A, Bray GA (1977 a) Comparison of metabolic alterations in hypothalamic and high fat diet-induced obesity. Am J Physiol 233: R162–R168

    Google Scholar 

  • Inoue S, Bray GA, Mullen Y (1977 b) The effect of transplantation of the pancreas on the development of hypothalamic obesity. Nature 266: 742–744

    Google Scholar 

  • Jarrett RJ, Bakir SM (1978) Insulin and obesity. Eur J Clin Invest 8: 359–360

    Article  PubMed  CAS  Google Scholar 

  • Jeanrenaud B (1979) Insulin and obesity. Diabetologia 17: 133–138

    Article  PubMed  CAS  Google Scholar 

  • Jeanrenaud B, Berthoud H-R, Bereiter DA, Rohner-Jeanrenaud F (1981) The role of the central nervous system in the regulation of the secretory activity of endocrine pancreas: a viewpoint from our laboratories. In: Enzi G, Crepaldi G, Pozza G, Renold AE (eds) Obesity: pathogenesis and treatment, vol 28. Academic, London, pp 23–35

    Google Scholar 

  • Kahn CR, Neville DM, Roth J (1973) Insulin-receptor interaction in the obese-hyperglycemic mouce. J Biol Chem 248: 244–250

    PubMed  CAS  Google Scholar 

  • Kalkhoff RK, Gossain VV, Matute ML (1973) Plasma glucagon in obesity. N Engl J Med 289: 465–467

    Article  PubMed  CAS  Google Scholar 

  • Karakash C, Hustvedt BE, Lovo A, le Marchand Y, Jeanrenaud B (1977) Consequences of ventromedial hypothalamic lesions on metabolism of perfused rat liver. Am J Physiol 232 (3): E286–E293

    PubMed  CAS  Google Scholar 

  • Karakash C, Rohner-Jeanrenaud F, Hustvedt BE, Jeanrenaud B (1980) Nitrogen handling in adult hypothalamic obese rats. Am J Physiol 238: E32–E37

    PubMed  CAS  Google Scholar 

  • Krug E (1978) Antilipolytic nature of gut GLI, and mode of action of two highly potent intestinal lipolytic species in birds. Horm Metab Res 10: 505–509

    Article  PubMed  CAS  Google Scholar 

  • Krug E, Mialhe P (1977) A possible role for gut GLI: an inhibitor of lipolysis. Horm Metab Res 6: 465–469

    Article  Google Scholar 

  • Laburthe M, Rancon F, Freychet P, Rosselin G (1975) Glucagon and insulin from lean rats and genetically obese fatty rats: studies by radioimmunoassay, radioreceptorassay and bioassay. Diabetologia 11: 517–526

    Article  PubMed  CAS  Google Scholar 

  • Langslow DR (1973) The action of gut glucagon like immunoreactivity and other intestinal hormones on lipolysis in chicken adipocytes. Horm Metab Res 5: 428–432

    Article  PubMed  CAS  Google Scholar 

  • Lassmann V, Vague P, Vialettes B, Simon MC (1980) Low plasma levels of pancreatic polypeptide in obesity. Diabetes 29: 428–430

    Article  PubMed  CAS  Google Scholar 

  • Laube H, Fussganger RD, Pfeiffer EF (1974) Paradoxical glucagon release in obese hyperglycemic mice. Horm Metab Res 6: 426

    Article  PubMed  CAS  Google Scholar 

  • Lavine RL, Voyles N, Perrino PY, Recant L (1975) The effect of fasting on tissue cyclic cAMP and plasma glucagon in the obese hyperglycemic mouse. Endocrinology 97: 615–620

    Article  PubMed  CAS  Google Scholar 

  • Lefebvre PJ, Unger RH, Valverde I, Rigopoulou D, Luyckx AS, Eisentraut A (1969) Effect of dog jejunum ‘glucagon like immunoreactive material’ on adipose tissue metabolism. Horm Metab Res 1: 143–144

    Article  PubMed  CAS  Google Scholar 

  • LeMarchand Y, Loten EG, Assimacopoulos-Jeannet F, Forgue ME, Freychet P, Jeanrenaud B (1977) Effect of fasting and streptozotocin in the obese hyperglycemic (ob/ob) mouse. Apparent lack of a direct relationship between insulin binding and insulin effects. Diabetes 26: 582–590

    Article  CAS  Google Scholar 

  • LeMarchand Y, Freychet P, Jeanrenaud B (1978) Longitudinal study on the establishment of insulin resistance in hypothalamic obese mice. Endocrinology 102: 74–85

    Article  CAS  Google Scholar 

  • Lemonnier D, Aubert R, Suquet JP, Rosselin G (1974) Metabolism of genetically obese rats on normal or high fat diet. Diabetologia 10: 697–701

    Article  PubMed  CAS  Google Scholar 

  • Liljenquist JE, Bomboy JD, Lewis SB, Sinclair Smith BC, Felts PW, Lacy WW (1974) Effects of glucagon on lipolysis and ketogenesis in normal and diabetic men. J Clin Invest 53: 190–197

    Article  PubMed  CAS  Google Scholar 

  • Livingston JN, Cuatrecasas P, Lockwood DH (1974) Studies of glucagon resistance in large rat adipocytes: 125-I labeled glucagon binding and lipolytic capacity. J Lipid Res 15: 26–38

    PubMed  CAS  Google Scholar 

  • Lockwood DH, Hamilton CL, Livingston JN (1979) The influence of obesity and diabetes in the monkey on insulin and glucagon binding to liver membranes. Endocrinology 104: 76–80

    Article  PubMed  CAS  Google Scholar 

  • Ma GY, Gove CD, Hem DA (1978) Effects of glucagon and insulin on fatty acid synthesis and glucagon degradation in the perfused liver of normal and genetically obese (ob/ob) mice. Biochem J 174: 761–768

    PubMed  CAS  Google Scholar 

  • Mahmoud HA, Wood PJ, Marks V (1978) The effect of induced hyperglucagonaemia on the Zucker fatty rat. Diabetologia 14: 405–412

    Article  Google Scholar 

  • Manganiello V, Vaughan M (1972) Selective loss of adipose cell responsiveness to glucagon with growth in the rat. J Lipid Res 13: 12–16

    PubMed  CAS  Google Scholar 

  • Marliss EB, Aoki TT, Unger RH, Soeldner JS, Cahill GF (1970) Glucagon levels and metabolic effects in fasting man. J Clin Invest 49: 2256–2270

    Article  PubMed  CAS  Google Scholar 

  • Marks Y (1973) Glucagon and lipid metabolism in man. Postgrad Med J 49: 615–619

    CAS  Google Scholar 

  • Meschi F, Garlaschi C, di Natale B, del Guercio MJ, Gargantini L, Chiumello G (1977) Glucagon response to arginine stimulation in obese and diabetic children. Diabetes 26: 558–560

    Article  PubMed  CAS  Google Scholar 

  • Minuk HL, Hanna AK, Marliss EB, Vranic M, Zinman B (1980) Metabolic response to moderate exercise in obese man during prolonged fasting. Am J Physiol 238: E322–E329

    PubMed  CAS  Google Scholar 

  • Müller WA, Faloona GR, Unger RH (1971) The influence of the antecedent diet upon glucagon and insulin secretion. N Engl J Med 285: 1450–1454

    Article  PubMed  Google Scholar 

  • Müller WA, Aoki TT, Cahill GF (1975) Effect of alanine and glycine on glucagon secretion in postabsorptive and fasting obese man. J Clin Endocrinol Metab 40: 418–425

    Article  PubMed  Google Scholar 

  • Müller WA, Aoki TT, Egdahl RH, Cahill GF (1977) Effects of exogenous glucagon and epinephrine in physiological amounts on the blood levels of free fatty acids and glycerol in dogs. Diabetologia 13: 55–58

    Article  PubMed  Google Scholar 

  • Nishikawa K, Ikeda H, Matsuo T (1981) Abnormal glucagon secretion in Zucker fatty rats. Horm Metab Res 13: 259–263

    Article  PubMed  CAS  Google Scholar 

  • Olefsky JM (1981) Insulin resistance and insulin action. An in vitro and in vivo perspective. Diabetes 30: 148–162

    PubMed  CAS  Google Scholar 

  • Paulsen EP, Lawrence AM (1968) Glucagon hypersecretion in obese children. Lancet 2:110

    Google Scholar 

  • Pozefsky T, Tancredi RG, Moxley RT, Dupre T, Tobin JD (1976) Metabolism of forearm tissues in man. Studies with glucagon. Diabetes 25: 128–135

    Google Scholar 

  • Rohner-Jeanrenaud F, Jeanrenaud B (1980) Consequences of ventromedial hypothalamic lesions upon insulin and glucagon secretion by subsequently isolated perfused pancreases in the rat. J Clin Invest 65: 902–910

    Article  PubMed  CAS  Google Scholar 

  • Rohner-Jeanrenaud F, Jeanrenaud B (1981) Possible involvement of the cholinergic system in hormonal secretion by the perfused pancreas from ventromedial-hypothalamic lesioned rats. Diabetologia 20: 217–222

    Google Scholar 

  • Santiago JY, Haymond MW, Clarke WL, Pagliara AS (1977) Glucagon, insulin, and glucose responses to physiologic testing in normal and massively obese adults. Metabolism 26: 1115–1122

    Article  PubMed  CAS  Google Scholar 

  • Savage PJ, Bennion LJ, Flock EV, Nagule-Sparan M, Mott D, Roth J, Unger RH, Bennett PH (1979) Diet-induced improvement of abnormalities in insulin and glucagon secretion and in insulin receptor binding in diabetes mellitus. J Clin Endocrinol Metab 48:999–1007

    Google Scholar 

  • Schade DS, Eaton RP (1974) Role of insulin and glucagon in obesity. Diabetes 23: 657–661

    PubMed  CAS  Google Scholar 

  • Schade DS, Eaton RP (1975 a) Altered tissue response to glucagon in obesity. J Clin Endocrinol Metab 40: 732–735

    Google Scholar 

  • Schade DS, Eaton RP (1976) Modulation of fatty acid metabolism by glucagon in man. IV. Effects of a physiologic hormone infusion in normal man. Diabetes 25: 978–983

    Article  PubMed  CAS  Google Scholar 

  • Schade DS, Eaton RP (1977) Modulation of the catabolic activity of glucagon by endogenous insulin secretion in obese man. Acta Diabetol Lat 14: 62–72

    Article  PubMed  CAS  Google Scholar 

  • Schade DS, Eaton RP (1975 b) The contribution of endogenous insulin secretion to the ketogenic response to glucagon in man. Diabetologia 11: 555–559

    Google Scholar 

  • Schade DS, Woodside W, Eaton RP (1979) The role of glucagon in the regulation of plasma lipids. Metabolism 28: 874–885

    Article  PubMed  CAS  Google Scholar 

  • Schemmel R, Mickelsen O, Gill JL (1970) Dietary obesity in rats: body weight and fat accretion in seven strains of rats. J Nutr 100: 1041–1048

    PubMed  CAS  Google Scholar 

  • Schneider P, Rabinovitch A, Paunier L, Sizonenko PC (1975) Alpha cell function in short, obese, and diabetic children. Pediatr Res 9: 733

    Article  PubMed  Google Scholar 

  • Seino S, Seino Y, Takemura J, Tsuda K, Kuzuya H, Ishikawa K, Shimazu T, Imura H (1981) Somatostatin, insulin and glucagon secretion from isolated perfused pancreas of obese rats. Am J Physiol 241: E146–E150

    PubMed  CAS  Google Scholar 

  • Sherwin RS, Fisher M, Hendler R, Felig P (1976) Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects. N Engl J Med 294: 455–461

    Article  PubMed  CAS  Google Scholar 

  • Sims EAH (1979) Syndromes of obesity. In: Degroot JL, Cahill GF, Odell WD, Martini L, Potts, JT, Nelson DH, Steinbergher E, Winegrad AT (eds) Endocrinology 3. Grune and Stratton, New York, pp 1941–1962

    Google Scholar 

  • Sorensen TIA, Nyboe Andersen A, Lauritsen KB, Holst J J, Stadil F, Andersen B (1983) Gut and pancreatic hormone profile after jejuno-ileal bypass with 3:1 or 1:3 jenunoileal ratio. Digestion 66: 137–145

    Google Scholar 

  • Tiengo A, Assan R, Tchobroutsky G (1972) Metabolic and hormonal patterns after three days of total fasting in 27 obese and non obese subjects. Isr J Med Sci 8: 821–822

    PubMed  CAS  Google Scholar 

  • Trovati M, Lorenzatio R, Cassader M, Pisu E, Martiny W, Pagano G (1981) Metabolic effects of short term treadmill exercise in moderately obese subjects. In: Enzi G, Crepaldi G, Pozza G, Renold AE (eds) Obesity: pathogenesis and treatment, vol. 28. Academic Press, London, pp 289–296

    Google Scholar 

  • Turpin BP, Austin MW, Solomon SS (1978) Urinary and plasma cyclic AMP levels during short term starvation in obese man: response to glucagon stimulation. Horm Metab Res 10: 36–37

    Article  PubMed  CAS  Google Scholar 

  • Vranic M, Morita S, Steiner G (1980) Insulin resistance in obesity as analyzed by the response of glucose kinetics to glucagon infusion. Diabetes 29: 169–176

    Article  PubMed  CAS  Google Scholar 

  • Walter RM, Gold EM, Michas CA, Ensinck JW (1980) Portal and peripheral vein concentrations of insulin and glucagon after arginine infusion in morbidly obese subjects. Metabolism 29: 1037–1041

    Article  PubMed  CAS  Google Scholar 

  • Wise JK, Hendler R, Felig P (1972) Obesity: evidence of decreased secretion of glucagon. Science 178: 513–514

    Article  PubMed  CAS  Google Scholar 

  • Wise JK, Hendler R, Felig P (1973 a) Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. J Clin Invest 52: 2774–2782

    Google Scholar 

  • Wise JK, Hendler R, Felig P (1973 b) Evaluation of alpha-cell function by infusion of alanine in normal, diabetic and obese subjects. N Engl J Med 288: 487–490

    Google Scholar 

  • Yen TT, Stamm NB, Fuller RW, Root MA (1980) Hepatic insensitivity to glucagon in ob/ 521 ob mice. Res Commun Chem Pathol Pharmacol 30: 29–40

    PubMed  CAS  Google Scholar 

  • Zucker TF, Zucker LM (1961) Fatty, a new mutation in the rat. J Hered 52: 275–278

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Holst, J.J. (1983). Glucagon in Obesity. In: Lefebvre, P.J. (eds) Glucagon II. Handbook of Experimental Pharmacology, vol 66 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69019-8_27

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69019-8_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69021-1

  • Online ISBN: 978-3-642-69019-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics