Glucagon II pp 19-41 | Cite as

The Amino Acid-Induced Secretion of Glucagon

  • R. Assan
  • M. Marre
  • M. Gormley
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 66 / 2)

Abstract

An increase in the amino acid concentration in contact with pancreatic A-cells is followed by a stimulation of glucagon release. This phenomenon is observed not only in vitro at some pharmacologic concentrations of amino acid, but also in vivo, during the rise in blood amino acid which follows a protein meal. The magnitude of the A-cell secretory response is modulated by the concomitant physiologic status, i.e., mainly the plasma glucose and insulin concentrations, and by the nutritional status in the preceding days: short-term and long-term influences can modify amino acid-induced glucagon release. As a clinical consequence of this phenomenon, the administration of an amino acid, or a mixture of amino acids has become a standard functional test for exploration of A-cells in vivo as well as in vitro.

Keywords

Lactate Alanine Leucine Verapamil Theophylline 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • R. Assan
  • M. Marre
  • M. Gormley

There are no affiliations available

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