Glucagon II pp 239-250 | Cite as

Glucagon and Pregnancy

  • C. Kühl
  • J. J. Holst
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 66 / 2)


The interest in obtaining knowledge of glucagon secretion in pregnancy emanates from two characteristic features of this state. First, pregnancy is known to exert a diabetogenic stress on carbohydrate metabolism and second, the metabolic responses to starvation and food intake are characteristically modified by gestation. Evaluation of the possible contributory role of glucagon in bringing about these metabolic changes in pregnancy is obviously of interest.


Late Pregnancy Glucagon Secretion Human Pregnancy Mixed Meal Plasma Glucagon 
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  1. Adam PA, King KC, Schwartz R, Teramo K (1972) Human placental barrier to 125-I-glucagon early in gestation. J Clin Endocrinol 34: 772–782CrossRefGoogle Scholar
  2. Aerts L, Van Assche FA (1975) Ultrastructural changes of the endocrine pancreas in pregnant rats. Diabetologia 11: 285–289PubMedCrossRefGoogle Scholar
  3. Alexander DP, Assan R, Britton HG, Nixon DA (1973) Impermeability of the sheep placenta to glucagon. Biol Neonate 23: 391–402CrossRefGoogle Scholar
  4. Alford FP, Bloom SR, Nabarro JDN, Hall R, Besser GM, Coy DH, Kastin AJ, Schally AV (1974) Glucagon control of fasting glucose in man. Lancet 2: 974–977PubMedCrossRefGoogle Scholar
  5. Andrews SS, Lopez A, Blackard WG (1975) Effects of lipids on glucagon secretion in man. Metabolism 24: 35–44PubMedCrossRefGoogle Scholar
  6. Beck-Nielsen H, Kühl C, Pedersen O, Bjerre-Christensen C, Toftegaard Nielsen T, Klebe JG (1979) Decreased insulin binding to monocytes from normal pregnant women. J Clin Endocrinol Metab 49: 810–814PubMedCrossRefGoogle Scholar
  7. Bellmann O, Hartmann E (1975) Influence of pregnancy on the kinetics of insulin. Am J Obstet Gynecol 122: 829–833PubMedGoogle Scholar
  8. Buchanan KD, McCarroll AM (1972) Abnormalities of glucagon metabolism in untreated diabetes mellitus. Lancet 2: 1394–1395PubMedCrossRefGoogle Scholar
  9. Burt RL, Davidson IWF (1974) Insulin half–life and utilization in normal pregnancy. Obstet Gynecol 43: 161–170PubMedGoogle Scholar
  10. Cherrington AD, Chiasson JL, Liljenquist JE, Jennings AS, Keller U, Lacy WW (1976) The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. J Clin Invest 58: 1407–1418PubMedCrossRefGoogle Scholar
  11. Chez RA, Mintz DH, Epstein MF, Fleichman AR, Oakes GK, Hutchinson DL (1974) Glucagon metabolism in non-human primate pregnancy. Am J Obstet Gynecol 120: 690–696PubMedGoogle Scholar
  12. Daniel RR, Metzger BE, Freinkel N, Faloona GR, Unger RH, Nitzan M (1974) Carbohydrate metabolism in pregnancy. XI. Response of plasma glucagon to overnight fast and oral glucose during normal pregnancy and in gestational diabetes. Diabetes 23: 771–776Google Scholar
  13. Fallucca F, Russo A, Tinelli FP, Giangrande L, Pedulla C, De Gado F, Pachi A (1979) Influence of pregnancy on glucagon levels in insulin-dependent diabetic women. Acta Diabetol Lat 16: 359–364PubMedCrossRefGoogle Scholar
  14. Freinkel N, Metzger BE, Nitzan M, Hare JW, Shambaugh GE, Marshall RT, Surmaczynska BZ, Nagel TC (1972) “Accelerated starvation” and mechanisms for the conservation of maternal nitrogen during pregnancy. Isr J Med Sei 8:826–839Google Scholar
  15. Freinkel N, Metzger BE, Nitzan M, Daniel R, Surmaczynska BZ, Nagel TC (1973) Facilitated anabolism in late pregnancy: Some novel maternal compensations for accelerated starvation. In: Malaisse WJ, Pirart J, Vallance-Owen J (eds) Diabetes. Proceedings of the Eighth Congress of the International Diabetes Federation. Excerpta Medica, Amsterdam London New York, p 474Google Scholar
  16. Gerich JE, Lorenzi M, Hane S, Gustafson G, Guillemin R, Forsham PH (1975) Evidence for a physiologic role of pancreatic glucagon in human glucose homeostasis: studies with somatostatin. Metabolism 24: 175–182PubMedCrossRefGoogle Scholar
  17. Hellman B (1960) The islets of Langerhans in the rat during pregnancy and lactation, with special reference to the changes in the B/A cell ratio. Acta Obstet Gynaecol Scand 39: 331–342CrossRefGoogle Scholar
  18. Hornnes PJ, Kühl C (1980) Plasma insulin and glucagon responses to isoglycemic stimulation in normal pregnancy and post partum. Obstet Gynecol 55: 425–427PubMedGoogle Scholar
  19. Hornnes P, Kühl C, Klebe JG (1978) Diminished gastrointestinal potentiation of insulin secretion in human pregnancy. Diabetologia 15: 165–168PubMedCrossRefGoogle Scholar
  20. Hornnes PJ, Kühl C, Lauritsen KB (1981a) Gastrointestinal insulinotropic hormones in normal and gestational diabetic pregnancy: response to oral glucose. Diabetes 30: 504–509PubMedCrossRefGoogle Scholar
  21. Hornnes PJ, Kühl C, Lauritsen KB (1981 b) Gastro-enteropancreatic hormones in normal pregnancy: response to a protein rich meal. Eur J Clin Invest 11: 345–349Google Scholar
  22. Johnston DI, Bloom SR, Greene KR, Beard RW (1972) Failure of the human placenta to transfer pancreatic glucagon. Biol Neonate 21: 375–380PubMedCrossRefGoogle Scholar
  23. Kaihan SC, D’Angelo LJ, Savin SM, Adam PAJ (1979) Glucose production in pregnant women at term gestation. Sources of glucose for human fetus. J Clin Invest 63: 388–394Google Scholar
  24. Kalkhoff RK, Kim H-J (1978) Effects of pregnancy on insulin and glucagon secretion by perifused rat pancreatic islets. Endocrinology 102: 623–631PubMedCrossRefGoogle Scholar
  25. Kitzmiller JL, Tanenberg RJ, Aoki TT, Tabatabaii A, Gleason R, Jewett JF, Hare JW, Soeldner JS (1980) Pancreatic alpha cell response to alanine during and after normal and diabetic pregnancies. Obstet Gynecol 56: 440–445PubMedGoogle Scholar
  26. Kühl C (1975) Glucose metabolism during and after pregnancy in normal and gestational diabetic women. I. Influence of normal pregnancy on serum glucose and insulin concentration during basal fasting conditions and after a challenge with glucose. Acta Endocrinol (Copenh) 79: 709–719Google Scholar
  27. Kühl C (1976) Serum proinsulin in normal and gestational diabetic pregnancy. Diabetologia 12: 295–300PubMedCrossRefGoogle Scholar
  28. Kühl C (1977) Serum insulin and plasma glucagon in human pregnancy on the pathogenesis of gestational diabetes. A review. Acta Diabetol Lat 14: 1–8PubMedCrossRefGoogle Scholar
  29. Kühl C, Holst J J (1976) Plasma glucagon and the insulin: glucagon ratio in gestational diabetes. Diabetes 25: 16–23PubMedCrossRefGoogle Scholar
  30. Kühl C, Hornnes P, Klebe JG (1977) Effect of pregnancy on the glucagon response to protein ingestion. Horm Metab Res 9: 206–209PubMedCrossRefGoogle Scholar
  31. Kühl C, Hornnes PJ, Faber OK (1981) Hepatic insulin extraction in human pregnancy. Horm Metab Res 13: 71–72PubMedCrossRefGoogle Scholar
  32. Leblanc H, Anderson JR, Yen SSC (1976) Glucagon secretion in late pregnancy and the puerperium. Am J Obstet Gynecol 125: 708–710PubMedGoogle Scholar
  33. Lefèbvre PJ, Luyckx AS (1979) Glucagon and diabetes: a reappraisal. Diabetologia 16: 347–354PubMedCrossRefGoogle Scholar
  34. Lind T, Billewicz WZ, Brown G (1973) A serial study of changes occurring in the oral glucose tolerance test during pregnancy. J Obstet Gynaecol Br Commonw 80: 1033–1039PubMedCrossRefGoogle Scholar
  35. Lind T, Bell S, Gilmore E, Huisjes H J, Schally AY (1977) Insulin disappearance rate in pregnant and non-pregnant women, and in non-pregnant women given GHRIH. Eur J Clin Invest 7: 47–51PubMedCrossRefGoogle Scholar
  36. Lind T, Burne JM, Kühl C (1979) Metabolic changes in pregnancy relevant to diabetes. In: Sutherland HW, Stowers JM (eds) Carbohydrate metabolism in pregnancy and the newborn. Springer, Berlin Heidelberg New York, p 32Google Scholar
  37. Lorrain J, Robillard R, Cartier A, Ross SA, Dupre J, Boskovic A, Hinse MC (1977) Glucagon secretion in pregnant women with suspected or mild diabetes mellitus. Can Med Assa J 116: 1289–1290Google Scholar
  38. Luyckx AS, Gérard J, Gaspard U, Lefèbvre PJ (1975) Plasma glucagon levels in normal women during pregnancy. Diabetologia 11: 549–554PubMedCrossRefGoogle Scholar
  39. Luyckx AS, Gaspard U, Lefèbvre PJ (1978) Influence of elevated plasma free fatty acids on the glucagon response to hypoglycemia in normal and in pregnant women. Metabolism 27: 1033–1040PubMedCrossRefGoogle Scholar
  40. Mackrell DJ, Sokal JE (1969) Antagonism between the effects of insulin and glucagon on the isolated liver. Diabetes 18: 724–732PubMedGoogle Scholar
  41. Metzger B, Pek S, Hare J, Freinkel N (1974) Relationships between glucose, insulin and glucagon during fasting in late gestation in the rat. Life Sei 15: 301–308CrossRefGoogle Scholar
  42. Metzger BE, Unger RH, Freinkel N (1977) Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a “mixed meal” in late pregnancy. Metabolism 26: 151–156Google Scholar
  43. Moore WMO, Ward BS, Gordon C (1974) Human placental transfer of glucagon. Clin Sei Mol Med 46: 125–129Google Scholar
  44. Müller WA, Faloona GR, Aguilar-Parada E, Unger RH (1970) Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med 283: 109–115Google Scholar
  45. Ohneda A, Aguilar-Parada E, Eisentraut AM, Unger RH (1968) Characterization of response of circulating glucagon to intraduodenal and intravenous administration of amino acids. J Clin Invest 47: 2305–2322PubMedCrossRefGoogle Scholar
  46. Pagliara AS, Stillings SN, Haymond MW, Hover BA, Matschinsky FM (1975) Insulin and glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats. J Clin Invest 55: 244–255PubMedCrossRefGoogle Scholar
  47. Park CR, Exton JH (1972) Glucagon and the metabolism of glucose. In: Lefèbvre PJ, Unger RH (eds) Glucagon. Pergamon, Oxford New York, p 77Google Scholar
  48. Pedersen J (1977) The pregnant diabetic and her newborn, 2nd edn. Williams & Wilkins, BaltimoreGoogle Scholar
  49. Phelps RL, Bergenstal R, Freinkel N, Rubenstein AH, Metzger BE, Mako M (1975) Carbohydrate metabolism in pregnancy. XIII. Relationships between plasma insulin and proinsulin during late pregnancy in normal and diabetic subjects. J Clin Endocrinol 41: 1085–1091Google Scholar
  50. Ravnikar V, Metzger BE, Freinkel N (1978) Is there a risk of “accelerated starvation” in normal human pregnancy? Diabetes 27:Abstr 132Google Scholar
  51. Saudek CD, Finkowski M, Knopp RH (1975) Plasma glucagon and insulin in rat pregnancy. Roles in glucose homeostasis. J Clin Invest 55: 180–187Google Scholar
  52. Unger RH (1971) Glucagon and the insulin: glucagon ratio in diabetes and other catabolic illnesses. Diabetes 29:834–838 Unger RH, Orci L (1975) The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet 1: 14–16Google Scholar
  53. Unger RH, Ohneda A, Aguilar-Parada E, Eisentraut AM (1969) The role of aminogenic glucagon secretion in blood glucose homeostasis. J Clin Invest 48: 810–822PubMedCrossRefGoogle Scholar
  54. Unger RH, Aguilar-Parade E, Müller WA, Eisentraut AM (1970) Studies of pancreatic alpha cell function in normal and diabetic subject. J Clin Invest 49: 837–848PubMedCrossRefGoogle Scholar
  55. Van Assche FA, Aerts L, De Prins F (1978) A morphological study of the endocrine pancreas in human pregnancy. Br J Obstet Gynaecol 85: 818–820PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • C. Kühl
  • J. J. Holst

There are no affiliations available

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