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Pharmacologic Compounds Affecting Glucagon Secretion

  • Chapter
Glucagon II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 2))

Abstract

The data accumulated in recent years leave little doubt that excessive plasma glucagon levels contribute to the metabolic abnormalities of diabetes (reviews in Unger 1978; Lefebvre and Luyckx 1979; see also Chap. 44). On the other hand, patients with glucagonoma often display an impressive clinical and biologic picture whose origin is best confirmed by its marked and rapid improvement by inhibitors of glucagon secretion (review in Luyckx and Lefebvre 1981; see also Chap. 43). These considerations imply that a search for drugs capable of reducing glucagon secretion is necessary. On the other hand, it would be of interest to know if a given compound can increase glucagon release since its administration would be potentially harmful to glucose metabolism.

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Authors
  1. A. S. Luyckx
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  1. University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Médecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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Luyckx, A.S. (1983). Pharmacologic Compounds Affecting Glucagon Secretion. In: Lefebvre, P.J. (eds) Glucagon II. Handbook of Experimental Pharmacology, vol 66 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69019-8_10

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