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Immune Complexes in Viral Infection

  • Chapter
New Developments in Diagnostic Virology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 104))

Abstract

The development of disease during viral infection may result from at least two major mechanisms, which are often combined. First, viruses can cause cell damage, directly or through the release of toxic products. Second, the cellular and humoral branches of the immune response directed against antigen(s) related to the infectious agent can also result in tissue injury. Although the production of antibody and its subsequent binding to antigen during the course of an immune response lead, in most cases, to antigen elimination, in vivo formation of immune complexes represents a major pathway for the pathological expression of the immune response. Indeed, immune complexes are formed when antibodies are produced and react with antigen molecule(s) persisting in the host or which are released from cells into extracellular fluids. In addition, some viruses are known to induce a polyclonal B cell proliferation resulting in the production of antibodies with a broad spectrum of specificity, including autoantibodies, and possibly lead to the formation of immune complexes involving self antigens or modified self antigens.

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  1. Department of Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, California, 91037, USA

    Paolo Casali & Michael B. A. Oldstone

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    Peter A. Bachmann

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Casali, P., Oldstone, M.B.A. (1983). Immune Complexes in Viral Infection. In: Bachmann, P.A. (eds) New Developments in Diagnostic Virology. Current Topics in Microbiology and Immunology, vol 104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68949-9_2

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