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The Use of Staphylococcal Protein A in Diagnostic Virology

  • Chapter
New Developments in Diagnostic Virology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 104))

Abstract

Staphylococcal protein A (SPA), a protein component of the cell wall of Staphylococcus aureus, binds the Fc portion of many immunoglobulins of most mammalian species. Verwey first described SPA in 1940 as a protein antigen present in type A staphylococci (coagulase-positive, a-toxin-positive, mannitol-fermenting, and pathogenic; i.e., S. aureus), but not in type B staphylococci (those lacking these characteristics). The systematic study of antigen A did not begin in earnest until two decades later (Jensen et al. 1961; Lofkvist and Sjoquist 1963; Grov et al. 1964). Grov and associates proposed the designation “protein A” to avoid confusion with the antigenic polysaccharide A (Grov et al. 1964).

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Authors and Affiliations

  1. Departments of Pathology and Medicine, Veterans Administration Medical Center and University of California, San Diego, California, USA

    Douglas D. Richman

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  1. Douglas D. Richman
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  1. Institut für Medizinische Mikrobiologie, Infektions- und Seuchenmedizin, Veterinärstr. 13, 8000, München 22, Germany

    Peter A. Bachmann

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© 1983 Springer-Verlag Berlin Heidelberg

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Richman, D.D. (1983). The Use of Staphylococcal Protein A in Diagnostic Virology. In: Bachmann, P.A. (eds) New Developments in Diagnostic Virology. Current Topics in Microbiology and Immunology, vol 104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68949-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-68949-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68951-2

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