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Properties of Virginiamycin-like Antibiotics (Synergimycins), Inhibitors Containing Synergistic Components

  • C. Cocito
Part of the Antibiotics book series (ANTIBIOTICS, volume 6)

Abstract

Antibiotics inhibiting protein synthesis in prokaryotes can be divided into three groups, according to their targets: (1) 30S ribosomal subunits, (2) 50S subunits; and (3) cytoplasmic factors (the initiation factors IF1, 2 and 3; the elongation factors EF-Tu, EF-Ts and EF-G; and the termination factors RF-1, 2 and 3) (Table 1). Virginiamycin-like antibiotics (synergimycins) belong to the second group. The articles of Weisblum and Davies (1968), Vázquez (1974), Pongs et al. (1974), and Pestka (1971,1976,1977), and the volumes of Vázquez (1979) and of Gale et al. (1981) review literature data on antibiotics acting at the ribosome level.

Keywords

Antimicrob Agent Ribosomal Subunit Initiation Complex Pipecolic Acid Peptidyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin · Heidelberg 1983

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  • C. Cocito

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