Skip to main content
SpringerLink
Log in

Molecular and Cellular Biology of Abelson Virus Transformation

  • Chapter
Retroviruses 1

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 103))

Overview

A tremendous increase in our knowledge of the variety of retroviral transforming genes and their complexity of structure and function has been attained within the last decade. Rapidly transforming, replication-defective retroviruses have gained a prominent position as systems to exploit in the study of the interactions of specific growth control genes and their host cells. A large number of independent isolates of such viruses from diverse vertebrate species (see Coffin et a1.1980) have been documented. The phenomenon of a specific host cell gene being recombined with part of the sequences of a replication-competent retrovirus and, hence, generating a new viral form and function has been demonstrated at the biological and molecular levels for a number of cases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abelson HT, Rabstein LS (1970a) Influence of prednisolone on Moloney leukemogenic virus in BALB/c mice. Cancer Res 30: 2208–2212

    CAS  Google Scholar 

  • Abelson HT, Rabstein LS (1970b) Lymphosarcoma: virus-induced thymic-independent disease in mice. Cancer Res 30: 2213–2222

    CAS  Google Scholar 

  • Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D (1981) Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27: 381–390

    Article  PubMed  CAS  Google Scholar 

  • Baltimore D, Rosenberg N, Witte ON (1979) Transformation of immature lymphoid cells by Abelson murine leukemia virus. Immunol Rev 48: 3–22

    Article  PubMed  CAS  Google Scholar 

  • Bishop JM (1978) Retroviruses. Annu Rev Biochem 47: 35–88

    CAS  Google Scholar 

  • Bishop JM (1980) Enemies within: the genesis of retrovirus oncogenes. Cell 23: 5–6

    Article  Google Scholar 

  • Blomberg J, Reynolds EH Jr, van de Ven WJM, Stephenson JR (1980) Abelson murine leukemia virus transformation involves loss of epidermal growth factor binding sites. Nature 286: 504–507

    Article  PubMed  CAS  Google Scholar 

  • Boss M, Greaves M, Teich N (1979) Abelson virus-transformed haematopoietic cell lines with pre-B cell characteristics. Nature 278: 551–553

    Article  PubMed  CAS  Google Scholar 

  • Boss MA, Dreyfuss G, Baltimore D (1981) Localization of the Abelson murine leukemia virus protein in a detergent insoluble subcellular matrix: architecture of the protein. J Virol 40: 472–481

    PubMed  CAS  Google Scholar 

  • Boyd AW, Schrader JW (1982) Derivation of macrophage-like lines from the pre-B lymphoma ABLS 8.1 using 5-azacytidine. Nature 297: 691–693

    Article  PubMed  CAS  Google Scholar 

  • Branceni D, Amason BG (1966) Thymic involution and recovery of immune responsiveness and immunoglobulins after neonatal prednisolone in rats. Immunology 10: 35–44

    PubMed  CAS  Google Scholar 

  • Coffin JM, Varmus HE, Bishop JM et al. (1981) Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol 40: 953–957

    PubMed  CAS  Google Scholar 

  • Collett MS, Erikson RL (1978) Protein kinase activity associated with the avian sarcoma virus srcgene product. Proc Natl Acad Sci USA 75: 2021–2024

    Article  PubMed  CAS  Google Scholar 

  • Cook WD (1982) Rapid thymomas induced by Abelson murine leukemia virus. Proc Natl Acad Sci USA 79: 2917–2921

    Article  PubMed  CAS  Google Scholar 

  • Cooper JA, Hunter T (1981) Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins. Mol Cell Biol 1: 394–407

    PubMed  CAS  Google Scholar 

  • Dale B, Ozanne B (1981) Characterization of mouse cellular DNA homologous to Abelson murine leukemia virus-specific sequences. Mol Cell Biol 1: 731–742

    PubMed  CAS  Google Scholar 

  • Dexter TM, Allen TD, Lajtha LG (1977) Conditions controlling the in vitro proliferation of hemopoietic stem cells in vitro. J Cell Physiol 91: 335–340

    Article  PubMed  CAS  Google Scholar 

  • Eckhart W, Hutchinson MA, Hunter T (1979) An activity phosphorylating tyrosine in Polyoma T antigen immunoprecipitates. Cell 18: 925–933

    Article  PubMed  CAS  Google Scholar 

  • Edwards SA, Fan H (1981) Immunoselection and characterization of Moloney-murine-leukemia-virus-infected cells lines deficient in surface gagantigen expression. Virology 113: 95–108

    Article  PubMed  CAS  Google Scholar 

  • Furth J (1946) Prolongation of life with prevention of leukemia by thymectomy in mice. J Gerontol 1: 46–54

    PubMed  CAS  Google Scholar 

  • Goff SP, Baltimore D (1982) The cellular oncogene of the Abelson murine leukemia virus genome. In: Klein G (ed) Viral oncology. Raven, New York

    Google Scholar 

  • Goff SP, Gilboa E, Witte ON, Baltimore D (1980) Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA. Cell 22: 777–786

    Article  PubMed  CAS  Google Scholar 

  • Goff SP, Witte ON, Gilboa E, Rosenberg N, Baltimore D (1981) Genome structure of Abelson murine leukemia virus variants: proviruses in fibroblasts and lymphoid cells. J Virol 38: 460–468

    PubMed  CAS  Google Scholar 

  • Goff SP, Tabin CI, Wang J, Weinberg R, Baltimore D (1982) Transfection of fibroblasts by cloned Abelson murine leukemia virus DNA and recovery of transmissible virus by recombination with helper virus. J Virol 41: 271–285

    PubMed  CAS  Google Scholar 

  • Gross L (1951) Pathologic properties and vertical transmission of the mouse leukemia agent. Proc Soc Exp Biol Med 78: 342–349

    PubMed  CAS  Google Scholar 

  • Gross L (1960) Development of myeloid (chloro-) leukemia in thymectomized C3H mice following inoculation of lymphatic leukemia virus. Proc Soc Exp Biol Med 103: 509–514

    PubMed  CAS  Google Scholar 

  • Grunwald DJ, Dale B, Dudley J, Lamph W, Sugden B, Ozanne B, Risser R (1982) Loss of viral gene expression and retention of tumorigenicity by Abelson lymphoma cells. J Virol 43: 92–103

    PubMed  CAS  Google Scholar 

  • Hunter T (1982) Synthetic peptide substrates for a tyrosine protein kinase. J Biol Chem 257: 4843–4848

    PubMed  CAS  Google Scholar 

  • Hunter T, Sefton B (1980) Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci USA 77: 1311–1315

    Article  PubMed  CAS  Google Scholar 

  • Kaplan HS (1950) Influence of thymectomy, splenectomy and gonadectomy on incidence of radiation-induced lymphoid tumors in strain C57 black mice. J Natl Cancer Inst 11: 83–90

    PubMed  CAS  Google Scholar 

  • Klein G, Ohno S, Rosenberg N, Weiner F, Spira J, Baltimore D (1980) Cytogenetic studies on Abelson-virus-induced mouse leukemias. Int J Cancer 25: 805–811

    Article  PubMed  CAS  Google Scholar 

  • Moloney JB (1960) Biological studies on a lymphoid leukemia virus extracted from sarcoma S37. I. Origin and introductory investigations. J Natl Cancer Inst 24: 933–995

    PubMed  CAS  Google Scholar 

  • Moloney JB (1962) The murine leukemias. Fed Proc 21: 19–31

    PubMed  CAS  Google Scholar 

  • Muller R, Slamon DJ, Tremblay JM, Cline MJ, Verma IM (1982) Differential expression of cellular oncogenes during pre-and postnatal development of the mouse. Nature

    Google Scholar 

  • Patschinsky T, Hunter T, Esch FS, Cooper JA, Sefton BM (1982) Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proc Nati Acad Sci USA 79: 973–977

    Article  CAS  Google Scholar 

  • Parks WP, Hawk RS, Anisowicz A, Scolnick EM (1976) Deletion mapping of Moloney type C virus: polypeptide and nucleic acid expression in different transforming virus isolates. J Virol 18: 491–503

    PubMed  CAS  Google Scholar 

  • Ponticelli AS, Whitlock CA, Rosenberg N, Witte ON (1982) In vivo tyrosine phosphorylations of the Abelson virus transforming protein are absent in its normal cellular homolog.

    Google Scholar 

  • Cell Potter M, Sklar MD, Rowe WP (1973) Rapid viral induction of plasmacytomas in pristane-primed BALB/c mice. Science 182: 592–594

    Article  Google Scholar 

  • Pratt DM, Strominger J, Parkman R, Kaplan D, Schwaber J, Rosenberg N, Scher CD (1977) Abelson-virus-transformed lymphocytes: null cells that modulate H-2. Cell 12: 683–690

    Article  PubMed  CAS  Google Scholar 

  • Rabstein LS, Gazdar AF, Chopra HC, Abelson HT (1971) Early morphological changes associated with infection by a murine non-thymic lymphatic tumor virus. J Nati Cancer Inst 46: 481–491

    CAS  Google Scholar 

  • Raschke WC, Ralph P, Watson J, Sklar M, Coon H (1975) Oncogenic transformation of murine lymphoid cells by in vitro infection with Abelson leukemia virus. J Natl Cancer Inst 54: 1249–1253

    PubMed  CAS  Google Scholar 

  • Raschke WC, Baird S, Ralph P, Nakoinz I (1978) Functional macrophage cell lines transformed by Abelson leukemia virus. Cell 15: 261–267

    Article  PubMed  CAS  Google Scholar 

  • Reynolds FH Jr, Sacks TL, Deobaghar DN, Stephanson JR (1978a) Cells non-productively transformed by Abelson murine leukemia virus express a high-molecular-weight polyprotein containing structural and non-structural components. Proc Natl Acad Sci USA 75: 3974–3978

    Article  CAS  Google Scholar 

  • Reynolds RK, van de Ven WJM, Stephenson JR (1978b) Translation of type C viral RNAs in Xenopus laevisoocytes: evidence that the 120 000-molecular-weight polyprotein expressed in Abelson-leukemia-virus-transformed cells is virus coded. J Virol 28: 665–670

    CAS  Google Scholar 

  • Reynolds FH, van de Ven WJM, Stephenson JR (1980) Abelson murine leukemia virus transformation-defective mutants with impaired P120-associated protein kinase activity. J Virol 36: 374–386

    PubMed  CAS  Google Scholar 

  • Risser R, Potter M, Rowe WP (1978a) Abelson-virus-induced lymphomagenesis in mice. J Exp Med 148: 714–726

    Article  CAS  Google Scholar 

  • Risser R, Stockert E, Old LJ (1978b) Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice. Proc Natl Acad Sci USA 75: 3918–3922

    Article  CAS  Google Scholar 

  • Rosenberg N, Baltimore D (1976) A quantitative assay for transformation of bone marrow cells by Abelson mutine leukemia virus. J Exp Med 143: 1453–1463

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg N, Baltimore D (1978) The effect of helper virus on Abelson-virus-induced transformation of lymphoid cells. J Exp Med 147: 1126–1141

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg N, Baltimore D (1980) Abelson virus. In: Klein G (ed) Viral oncology. Raven, New York, pp 187–203

    Google Scholar 

  • Rosenberg N, Witte ON (1980) Abelson murine leukemia virus mutants with alterations in the virus-specific P120 molecule. J Virol 33: 340–348

    PubMed  CAS  Google Scholar 

  • Rosenberg N, Baltimore D, Scher CD (1975) In vitro transformation of lymphoid cells by Abelson mutine leukemia virus. Proc Natl Acad Sci USA 72: 1932–1936

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg N, Clark DR, Witte ON (1980) Abelson mutine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation. J Virol 36: 766–774

    PubMed  CAS  Google Scholar 

  • Rotter V, Witte ON, Coffman R, Baltimore D (1980) Abelson-murine-leukemia-virus-induced tumors elicit antibodies against a host cell protein P50. J Virol 36: 547–555

    PubMed  CAS  Google Scholar 

  • Rotter V, Boss MA, Baltimore D (1981) Increased concentration of an apparently identical cellular protein in cells transformed by either Abelson murine leukemia virus or other transforming agents. J Virol 38: 336–346

    PubMed  CAS  Google Scholar 

  • Scher CD (1978) Effect of pseudotype on Abelson-virus-and Kirsten-sarcoma-virus-induced leukemia. J Exp Med 147: 1044–1053

    Article  PubMed  CAS  Google Scholar 

  • Scher CD, Siegler R (1975) Direct transformation of 3T3 cells by Abelson murine leukemia virus. Nature 253: 729–731

    Article  PubMed  CAS  Google Scholar 

  • Schultz AM, Lockhart SM, Rabin EM, Oroszlan S (1981) Structure of glycosylated and unglycosylated gagpolyproteins of Rauscher murine leukemia virus: carbohydrate attachment sites. J Virol 28: 581–592

    Google Scholar 

  • Sefton BM, Hunter T, Raschke WC (1981) Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. Proc Natl Acad Sci USA 78: 1552–1556

    Article  PubMed  CAS  Google Scholar 

  • Shields A, Otto G, Goff S, Baltimore D (1979) Structure of the Abelson murine leukemia virus genome. Cell 18: 955–962

    Article  PubMed  CAS  Google Scholar 

  • Shilo B-Z, Weinberg RA (1981) DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster. Proc Natl Acad Sci USA 78: 6789–6792

    Article  PubMed  CAS  Google Scholar 

  • Shinefeld LA, Sato VL, Rosenberg NE (1980) Monoclonal rat anti-mouse-brain antibody detects Abelson mutine leukemia virus target cells in mouse bone marrow Cell 20: 11–17

    CAS  Google Scholar 

  • Shinnick TM, Lerner RA, Sutcliffe JG (1981) Nucleotide sequence of Moloney murine leukemia virus. Nature 293: 543–548

    Article  PubMed  CAS  Google Scholar 

  • Siden EJ, Baltimore D, Clark D, Rosenberg N (1979) Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell 16: 389–396

    Article  PubMed  CAS  Google Scholar 

  • Siegler R, Rich MA (1966) Pathogenesis of murine leukemia. Natl Cancer Inst Monogr 22: 525–597

    PubMed  CAS  Google Scholar 

  • Siegler R, Zajdel S, Lane I (1972) Pathogenesis of Abelson-virus-induced murine leukemia. J Natl Cancer Inst 48: 189–218

    PubMed  CAS  Google Scholar 

  • Silverstone A, Sun L, Witte ON, Baltimore D (1980) Biosynthesis of murine terminal deoxynucleotidyl transferase. J Biol Chem 255: 791–796

    PubMed  CAS  Google Scholar 

  • Sklar MD, Shevach EM, Green I, Potter M (1975) Transplantation and preliminary characterization of lymphocyte surface markers of Abelson-virus-induced lymphomas. Nature 253: 550–552

    Article  PubMed  CAS  Google Scholar 

  • Srinivasan A, Premkumar-Reddy E, Aaronson SA (1981) Abelson murine leukemia virus: molecular cloning of infectious integrated proviral DNA. Proc Natl Acad Sci USA 78: 2077–2081

    Article  PubMed  CAS  Google Scholar 

  • Twardzik DR, Todaro GJ, Marguardt H, Reynolds FH Jr, Stephenson JR (1982) Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor. Science 216: 894–896

    Article  PubMed  CAS  Google Scholar 

  • van de Ven WJM, Reynolds FH Jr, Stephenson JR (1980) The nonstructural components of polyproteins encoded by replication-defective mammalian transforming retroviruses are phosphorylated and have associated protein kinase activity. Virology 101: 185–197

    Article  PubMed  Google Scholar 

  • Waneck G, Rosenberg N (1981) Abelson leukemia virus induces lymphoid and erythroid colonies in infected fetal cell cultures. Cell 26: 79–89

    Article  PubMed  CAS  Google Scholar 

  • Waneck G, Rosenberg N (1981) Abelson leukemia virus induces lymphoid and erythroid colonies in infected fetal cell cultures. Cell 26: 79–89

    Article  PubMed  CAS  Google Scholar 

  • Westin EH, Wong-Staal F, Gelman EP et al. (1982) Expression of cellular homologies of retroviral onegenes in human hematopoietic cells. Proc Natl Acad Sci USA 79: 2490–2494

    Article  PubMed  CAS  Google Scholar 

  • Whitlock CA, Witte ON (1981) Abelson-virus-infected cells can exhibit restricted in vitro growth and low oncogenic potential. J Virol 40: 577–584

    PubMed  CAS  Google Scholar 

  • Whitlock CA, Witte ON (1982a) Long-term culture of B-lymphocytes and their precursors from murine bone marrow. Proc Nall Acad Sci USA 79: 3608–3612

    Article  CAS  Google Scholar 

  • Whitlock CA, Witte ON (1982a) Long-term culture of B-lymphocytes and their precursors from murine bone marrow. Proc Nall Acad Sci USA 79: 3608–3612

    Article  CAS  Google Scholar 

  • Witte ON, Wirth D (1979) Structure of the murine leukemia virus envelope glycoprotein precursor. J Virol 29: 735–743

    PubMed  CAS  Google Scholar 

  • Witte ON, Rosenberg N, Paskind M, Shields A, Baltimore D (1978) Identification of an Abelsonmurine-leukemia-virus-encoded protein present in transformed fibroblast and lymphoid cells. Proc Natl Acad Sci USA 75: 2488–2492

    Article  PubMed  CAS  Google Scholar 

  • Witte ON, Sun L, Rosenberg N, Baltimore D (1979) A transacting protein kinase identified in cells transformed by Abelson murine leukemia virus. Cold Spring Harbor Symposia on Quantitative Biology 44: 855–857

    Google Scholar 

  • Witte ON, Rosenberg N, Baltimore D (1979a) Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson-MuLV-encoded P120 protein at the cell surface. J Virol 31: 776–784

    CAS  Google Scholar 

  • Witte ON, Rosenberg N, Baltimore D (1979b) Identification of a normal cellular protein cross-reactive to the major Abelson mutine leukemia virus gene product. Nature 281: 396–398

    Article  CAS  Google Scholar 

  • Witte ON, Dasgupta A, Baltimore D (1980a) Abelson murine leukemia veins protein is phosphory-lated in vitro to form phosphotyrosine. Nature 283: 826–831

    Article  CAS  Google Scholar 

  • Witte ON, Goff S, Rosenberg N, Baltimore D (1980b) A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity. Proc Natl Acad Sci USA 77: 4993–4997

    Article  CAS  Google Scholar 

  • Witte ON, Ponticelli A, Gifford A, Baltimore D, Rosenberg N, Elder J (1981) Phosphorylation of the Abelson mutine leukemia virus transforming protein. J Virol 39: 870–878

    PubMed  CAS  Google Scholar 

  • Ziegler SF, Whitlock CA, Goff SP, Gifford A, Witte ON (1981) Lethal effect of the Abelson mutine leukemia virus transforming gene product. Cell 27: 477–486

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Molecular Biology Institute, University of California, Los Angeles, CA, 90024, USA

    Owen N. Witte

Authors
  1. Owen N. Witte
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dept. of Microbiology, University of Southern California, School of Medicine, 2011 Zonal Avenue HMR 401, 90033, Los Angeles, California, USA

    P. K. Vogt

  2. The Wistar Institute, 36th Street at Spruce, 19104, Philadelphia, PA, USA

    Hilary Koprowski

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Witte, O.N. (1983). Molecular and Cellular Biology of Abelson Virus Transformation. In: Vogt, P.K., Koprowski, H. (eds) Retroviruses 1. Current Topics in Microbiology and Immunology, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68943-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68943-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68945-1

  • Online ISBN: 978-3-642-68943-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation