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Antibiotics pp 371–397Cite as

Toxicology of β-Lactam Antibiotics

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 67 / 2))

Abstract

One of the most important qualities of the animal and human pharmacology of the first penicillins has been a remarkably favorable chemotherapeutic index. Aside from problems of local irritation and of neurotoxicity with extremely large doses, these antibiotics have minimal direct toxicity. For nearly 20 years, allergic or immune-mediated reactions represented the only common complications of the use of penicillins. However, the development of the newer penicillins and the cephalosporins, although providing some of the safest and most important antibiotics in current use, has introduced new problems in direct, nonallergic toxicity.

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Authors
  1. M. C. Browning
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  2. B. M. Tune
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Editors and Affiliations

  1. Fermentation of Microbiology Laboratory Department of Nutrition and Food Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA

    Arnold L. Demain  & Nadine A. Solomon  & 

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Browning, M.C., Tune, B.M. (1983). Toxicology of β-Lactam Antibiotics. In: Demain, A.L., Solomon, N.A. (eds) Antibiotics. Handbook of Experimental Pharmacology, vol 67 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68901-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-68901-7_5

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