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Hormonell induzierte Diarrhöen

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Dünndarm B

Part of the book series: Handbuch der inneren Medizin ((INNEREN 3,volume 3 / 3 / B))

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Zusammenfassung

Unter dem Begriff der hormonell induzierten Diarrhö werden eine Reihe sehr heterogener Krankheitsbilder zusammengefaßt. Die gemeinsamen Leitsymptome dieser Erkrankungen sind 1. wäßrige Durchfälle, die bei Nahrungskarenz persistieren, also sekretorischer Natur sind, und 2. autonome Produktion eines oder mehrerer Hormone in Pankreas oder Gastrointestinaltrakt oder gelegentlich auch anderen Organen.1 Zollinger U. Ellison (1955) erkannten als erste den Zusammenhang zwischen Inselzelltumoren des Pankreas und therapieresistenten peptischulzerösen Läsionen des oberen Gastrointestinaltrakts. Das pathogenetische Bindeglied Gastrin, welches über die gastrale Hypersekretion von Säure und Pepsin zur Ulkusbildung führt, wurde von Gregory et al. (1960) aus einem Zollinger-Ellison-Tumor extrahiert. Die nicht selten zu beobachtenden Durchfälle führte man zunächst auf die begleitende Steatorrhö als Folge der Inaktivie- rung pankreatischer Enzyme durch die Ubersäuerung des Intestinaltrakts zurück (Maynard U. Point 1958); in rascher Folge erschienen jedoch Fallberichte, in denen wäßrige Durchfälle und Hypokaliämie im Vordergrund standen (Priest u. Alexander 1957), peptische Ulzera hingegen fehlen konnten (Ellison U. Wilson 1964). Verner U. Morrison (1958) beschrieben 2 Fälle von Inselzellade-nom mit letaler Diarrhö und Hypokaliämie; peptische Läsionen waren nicht vorhanden, jedoch wurde die Magensäureproduktion nicht gemessen. Die Abgrenzung dieses Syndroms vom Zollinger-Ellison-Syndrom geschah durch Knappe et al. (1966) und Marks et al.

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Literatur

  • Al-Awqati Q, Field M, Pierce NF, Greenough WB (1970) Effect of prostaglandin E1 on electrolyte transport in rabbit ileal mucosa. J Clin Invest 49: 2a

    Google Scholar 

  • Allison DJ, Modlin IM, Jenkins WJ (1977) Treatment of carcinoid liver metastases by hepatic-artery embolisation. Lancet 2: 1323–1325

    Article  PubMed  CAS  Google Scholar 

  • Bank S, Marks IN (1963) Malabsorption in systemic mast cell disease. Gastroenterology 45: 535–549

    PubMed  CAS  Google Scholar 

  • Barbezat GO (1973) Stimulation of intestinal secretion by polypeptide hormones. Scand J Gastroenterol 22: 3–21

    Google Scholar 

  • Barbezat GO, Grossman MI (1971a) Choleralike diarrhoea induced by glucagon plus gastrin. Lancet 1: 1025–1026

    Article  PubMed  CAS  Google Scholar 

  • Barbezat GO, Grossman MI (1971b) Intestinal secretion: stimulation by peptides. Science 174: 422–434

    Article  PubMed  CAS  Google Scholar 

  • Barrowman JA, Bennet A, Hillenbrand P, Polles L, Pollock DJ, Wright JT (1975) Diarrhea in thyroid medullary carcinoma: role of prostaglandins and the therapeutic effect of nutmeg. Br J Med 3: 11–12

    Article  CAS  Google Scholar 

  • Bennet A, Eley KG, Scholes GB (1968) Effect of prostaglandins Ex and E2 on intestinal motility in the guinea pig and rat. Br J Pharmacol 34: 639–647

    Google Scholar 

  • Bennet A, Gradidge CF, Stamford IF (1974) Prostaglandins, nutmeg and diarrhea. N Engl J Med 290: 110–111

    Google Scholar 

  • Bernier J J, Rambaud JC, Cattan D, Prost A (1969) Diarrhea associated with medullary carcinoma of the thyroid. Gut 10: 980–985

    Article  PubMed  CAS  Google Scholar 

  • Bloom SR (1978) Vasoactive intestinal peptide, the major mediator of the WDHA (pancreatic cholera) syndrome: value of measurement in diagnosis and treatment. Am J Dig Dis 23: 373–376

    Article  PubMed  CAS  Google Scholar 

  • Bloom SR, Polak JM (1976) VIP measurement in distinguishing Verner-Morrison syndrome and pseudo Verner-Morrison syndrome. Clin Endocrinol (Oxf) 5:223 s–228 s

    Google Scholar 

  • Bloom SR, Polak JM, Pearse AGE (1973) Vasoactive intestinal peptide and watery diarrhea syndrome. Lancet 2: 14–16

    Article  PubMed  CAS  Google Scholar 

  • Bloom SR, Nalin DR, Mitchell SJ, Bryant MG (1976) High levels of VIP in cholera stool water. Gut 17: 817

    Google Scholar 

  • Bloom SR, Christofides ND, Besterman HS (1978) Raised motilin in diarrhea. Gut 19: A 959

    Google Scholar 

  • Bloom SR, Besterman HS, Welsby PD, Christofides ND, Sason DL (1979) Gut hormones in acute diarrhea. Gastroenterology 76: 1102

    Google Scholar 

  • Bonfils S, René E, Pignal F, Rambaud JC (1979) Rebound effect after somatostatin treatment in Verner-Morrison syndrome. Lancet 2: 476

    Article  PubMed  CAS  Google Scholar 

  • Broder LE, Carter SK (1973 a) Pancreatic islet cell carcinoma. I. Clinical features of 52 patients. Ann Intern Med 79: 101–107

    Google Scholar 

  • Broder LE, Carter SK (1973 b) Pancreatic islet cell carcinoma. II. Results of therapy with streptozoto-cin in 52 Patients. Ann Intern Med 79: 108–118

    Google Scholar 

  • Broor SL, Soergel KH, Garancis JC, Wilson SD (1979) Hormone producing pancreatic islet cell carcinoma: changing clinical presentation. Am J Med Sci 278: 229–233

    Article  PubMed  CAS  Google Scholar 

  • Brozmyski EM, Woodruff K, Sessions JT (1973) Zollinger-Ellison syndrome with hypoglycemia associated with calcification of the tumor and its metastases. Gastroenterology 65: 658–661

    Google Scholar 

  • Bülbring E, Lin RCY (1958) The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. J Physiol (Lond) 40: 381–4107

    Google Scholar 

  • Bukhave K, Rask-Madsen J (1980) Saturation kinetics applied to in vitro effects of low prostaglandin E2 and F2a concentrations onion transport across human jejunal mucosa. Gastroenterology 78: 32–42

    PubMed  CAS  Google Scholar 

  • Burkhardt A (1976) Das Verner-Morrison-Syndrom. Klinik und pathologische Anatomie. Klin Wochenschr 54: 1–11

    Article  PubMed  CAS  Google Scholar 

  • Bynum TE, Jacobson ED, Johnson LR (1971) Gastrin inhibition of intestinal absorption in dogs. Gastroenterology 61: 858–862

    PubMed  CAS  Google Scholar 

  • Cameron DG, Warner HA, Szabo HA (1967) Chronic diarrhea in an adult with hypokalemic nephropathy and osteomalacia due to a functioning ganglioneuroblastoma. Am J Med Sci 253: 417–424

    Article  PubMed  CAS  Google Scholar 

  • Caspary WF, Lücke H (1976) Effects of chronic glucagon administration on the digestive and absorptive function of rat small intestine in vivo. Res Exp Med (Berl) 167: 1–13

    Article  CAS  Google Scholar 

  • Cerda JJ, Raffensperger EC, Rawnsley HM (1970) Cholera-like syndrome and pancreatic islet cell tumors. Med Clin North Am 54: 567–575

    PubMed  Google Scholar 

  • Charney AN, Kinsey D, Myers L, Gianella RA, Gots RAE (1975) Na + −K+ Reactivated adenosine triphosphatase and intestinal electrolyte transport. Effect of adrenal steroids. J Clin Invest 56: 653–660

    Google Scholar 

  • Classen M, Koch H, Bickhardt J, Topf G, Demling L (1971) The effect of prostaglandin Et on the pentagastrin-stimulated gastric secretion in man. Digestion 4: 333–344

    Article  PubMed  CAS  Google Scholar 

  • Cooperman AV, Desantis D, Winkelman E, Farmer R, Eversman J, Said S (1978) Watery diarrhea syndrome: two unusual cases and further evidence that VIP is a humoral mediator. Ann Surg 187: 325–328

    Article  PubMed  CAS  Google Scholar 

  • Cox TM, Fagan EA, Hillyard CJ, Allison DJ, Chadwick VS (1979) Role of calcitonin in diarrhea associated with medullary carcinoma of the thyroid. Gut 20: 629–633

    Article  PubMed  CAS  Google Scholar 

  • Creutzfeldt W, Arnold R (1979) Endokrine Tumoren des Pankreas. Internist 20: 382–391

    PubMed  CAS  Google Scholar 

  • Davies GR, Camp RC, Raskin P, Krejs GJ (1980) Effect of somatostatin infusion on jejunal water and electrolyte transport in a patient with secretory diarrhea due to malignant carcinoid syndrome. Gastroenterology 78: 346–349

    Google Scholar 

  • Davis Z, Moertel CG, Mcllrath (1973) The malignant carcinoid syndrome. Surg Gynecol Obstet 137: 637–644

    CAS  Google Scholar 

  • Dharmsathaphorn K, Sherwin RS, Cataland S (1980 a) Somatostatin inhibits diarrhea in the carci-noid syndrome. Ann Intern Med 90: 68–69

    Google Scholar 

  • Dharmsathaphorn K, Sherwin RS, Dobbins JW (1980 b) Somatostatin inhibits fluid secretion in the rat jejunum. Gastroenterology 78: 1554–1558

    Google Scholar 

  • Dharmsathaphorn K, Binder HJ, Dobbins JW (1980 c) Somatostatin stimulates sodium- and chloride absorption in the rabbit ileum. Gastroenterology 78: 1559–1565

    Google Scholar 

  • Domschke S, Domschke W, Bloom SR, Mitznegg P, Mitchell SJ, Lux G, Strunz U (1978) Vasoactive intestinal peptide in man: pharmacokinetics, metabolic and circulatory effects. Gut 19: 1049–1053

    Article  PubMed  CAS  Google Scholar 

  • Donowitz M, Binder HJ (1975) Jejunal fluid and electrolyte secretion in carcinoid syndrome. Am J Dig Dis 20: 1115–1122

    Article  PubMed  CAS  Google Scholar 

  • Donowitz M, Charney AN, Hefferman JM (1977) Effect of serotonin on intestinal transport in the rabbit. Am J Physiol 232: E85–E94

    PubMed  CAS  Google Scholar 

  • Donowitz M, Elta G, Bloom SR, Nathanson L (1980) Trifluoperazine reversal of secretory diarrhea in pancreatic cholera. Ann Intern Med 93: 284–285

    PubMed  CAS  Google Scholar 

  • Einstein N, Baker A, Galper J, Wolfe H (1975) Jaundice due to nicotinic acid therapy. Am J Dig Dis 20: 282–286

    Article  PubMed  CAS  Google Scholar 

  • Elias E, Bloom SR, Welbourn RB, Kuzio M, Polak JM, Pearse AGE, Booth CC, Brown JC (1972) Pancreatic cholera due to production of gastric inhibitory polypeptide. Lancet 2: 791–793

    Article  PubMed  CAS  Google Scholar 

  • Ellison EH, Wilson SD (1964) The Zollinger-Ellison Syndrome: reappraisal and evaluation of 260 registered cases. Ann Surg 160: 512–518

    Article  PubMed  CAS  Google Scholar 

  • Engleman K, Lovenberg W, Sjoerdsma A (1967) Inhibition of serotonin synthesis by parachlorphenylalanine in patients with the carcinoid syndrome N Engl J Med 277: 1103

    Google Scholar 

  • Evanson JM, Stanbury SW (1965) Congenital chloridorrhea or so-called congenital alkalosis with diarrhea. Gut 6: 29–38

    Article  PubMed  CAS  Google Scholar 

  • Fausa O, Fretheim B, Elgio K, Semb LS, Gjone E (1973) Intractable watery diarrhea, hypokalemia and achlorhydria associated with nonpancreatic retroperitoneal neurogenous tumor containing vasoactive intestinal polypeptide. Scand J Gastroenterol 8: 713–717

    PubMed  CAS  Google Scholar 

  • Fawell WN, Thompson G (1973) Nutmeg for diarrhea of medullary carcinoma of thyroid. N Engl J Med 289: 108–109

    PubMed  CAS  Google Scholar 

  • Feldman JM, Plonk JW, Cornette JC (1974) Serum prostaglandin F2 concentrations in the carcinoid syndrome. Prostaglandins 7: 501–506

    Article  PubMed  CAS  Google Scholar 

  • Feyrter F (1938) Über diffuse endokrine epitheliale Organe. Zentralbl Inn Med 545: 31–41

    Google Scholar 

  • Fox RH, Hilton SM (1958) Bradykinin formation in human skin as a factor in heat vasodilation. J Physiol 142: 219–232

    PubMed  CAS  Google Scholar 

  • Gaginella TS, D’Orisio TM, Wu ZC, Mekhjian HS, Cataland S (1978) Pancreatic polypeptide: effect on fluid transport in the small and large intestine of the rat. Clin Res 26:661 A

    Google Scholar 

  • Gardner JD (1978) Plasma VIP in patients with watery diarrhea syndrome. Am J Dig Dis 23: 370–373

    Article  PubMed  CAS  Google Scholar 

  • Gardner JD, Peskin GW, Cerda JJ, Brooks FP (1967) Alterations of in vitro fluid and electrolyte absorption by gastrointestinal hormones. Am J Surg 113: 57–64

    Article  PubMed  CAS  Google Scholar 

  • Gingell JC, Davies MW, Shields RC (1968) Effect of a synthetic gastrinlike pentapeptide upon the intestinal transport of sodium, potassium and water. Gut 9: 111–116

    Article  PubMed  CAS  Google Scholar 

  • Gray TK, Bieberdorf FA, Fordtran JS (1973) Thyrocalcitonin and the jejunal absorption of calcium, water and electrolytes in normal subjects. J Clin Invest 52: 3084–3088

    Article  PubMed  CAS  Google Scholar 

  • Gregory RA, Tracy HJ, French JM, Sircus W (1960) Extraction of a gastrinlike substance from a pancreatic tumor in a case of Zollinger-Ellison syndrome. Lancet 1: 1045–1048

    Article  PubMed  CAS  Google Scholar 

  • Grotting JC, Kassel S, Dehner LP (1979) Nesidioblastosis and congenital neuroblastoma. Arch Pathol Lab Med 103: 642–646

    PubMed  CAS  Google Scholar 

  • Gutierrez JG, Chey WY, Dinoso VP (1974) Actions of cholecystokinin and secretin on the motor activity of the small intestine in man. Gastroenterology 67: 35–41

    PubMed  CAS  Google Scholar 

  • Hamilton JR, Radde IC, Johnson G (1968) Diarrhea associated with adrenal ganglioneuroma. Am J Med 44: 453–463

    Article  PubMed  CAS  Google Scholar 

  • Hammar S, Sale G (1975) Multiple homone producing islet cell carcinoma of the pancreas. A morphological and biochemical investigation. Hum Pathol 6: 349–362

    Google Scholar 

  • Harris DW, Swan CHJ, Smith PR (1978) Venous prostaglandin-like activity in diarrhoeal states. Gut 19: 1057–1058

    Article  PubMed  CAS  Google Scholar 

  • Haverback BJ, Davidson JD (1958) Serotonin and the gastrointestinal tract. Gastroenterology 35: 570–578

    PubMed  CAS  Google Scholar 

  • Helman CA, Barbezat GO (1977) The effect of gastric inhibitory polypeptide on human jejunal water and electrolyte transport. Gastroenterology 72: 376–379

    PubMed  CAS  Google Scholar 

  • Hicks T, Turnberg LA (1972) The influence of secretin on ion transport in the human jejunum. Gut 14: 485–490

    Article  Google Scholar 

  • Hicks T, Turnberg LA (1974) Influence of glucagon on the human jejunum. Gastroenterology 67: 1114–1118

    PubMed  CAS  Google Scholar 

  • Holmgren J, Lange S, Lönnroth I (1978) Reversal of cyclic AMP-mediated intestinal secretion by chlorpromazine. Gastroenterology 75: 1103–1108

    PubMed  CAS  Google Scholar 

  • Horton EW, Main IHM, Thompson CJ, Wright PM (1968) Effect of orally administered prostaglandin Ex on gastric secretion and gastrointestinal motility in man. Gut 9: 655–658

    Article  PubMed  CAS  Google Scholar 

  • Isaacs P, Whittaker SM, Turnberg LA (1974) Diarrhea associated with medullary carcinoma of the thyroid - studies of intestinal function in a patient. Gastroenterology 67: 521–526

    PubMed  CAS  Google Scholar 

  • Jaffe BM (1979) To be or not to VIP. Editorial. Gastroenterology 76:417–420 Jaffe BM, Condon S (1976) Prostaglandins E and F in endocrine diarrheagenic syndromes. Ann Surg 184: 516–523

    Google Scholar 

  • Jaffe BM, Behrman HR, Parker CW (1973) Radioimmunoassay measurement of prostaglandins E, A and F in human plasma. J Clin Invest 52: 398–405

    Google Scholar 

  • Jaffe BM, Kopen DF, DeSchryver-Kecskemeti K, Gingerich RL, Greider M (1977) Indomethacin- responsive pancreatic cholera. N Engl J Med 297: 817–823

    Article  PubMed  CAS  Google Scholar 

  • Judge DM, Demers LM, Nahrwold DL (1977) Vasoactive intestinal polypeptide and gastrin producing islet cell carcinoma. Arch Pathol Lab Med 101: 262–265

    PubMed  CAS  Google Scholar 

  • Kachelhoffer J, Mendel C, Dauchel J, Hohmatter D, Greiner JF (1976) The effects of VIP on intestinal jejunal loops. Am J Dig Dis 21: 957–962

    Article  PubMed  CAS  Google Scholar 

  • Kahn CR, Levy AG, Gardner JD, Miller JV, Görden P, Schein PS (1975) Pancreatic cholera: beneficial effects of treatment with streptozotocin. N Engl J Med 292: 941–945

    Article  PubMed  CAS  Google Scholar 

  • Kaufman E, Dinno MA, Huang KC (1980) Effect of glucagon onion transport in mouse intestine. Am J Physiol 238:G 491–494

    Google Scholar 

  • Kehrins C, Said SI (1973) Hyperglycemic and glycogenolytic effects of vasoactive intestinal polypeptide. Proc Soc Exp Biol Med 142: 1014–1017

    Google Scholar 

  • Kidd GS, Donowitz M, O’Dorisio T, Cataland S, Newman F (1979) Mild chronic watery diarrhea- hypokalemia syndrome associated with pancreatic islet cell hyperplasia. Am J Med 66: 883–888

    Article  PubMed  CAS  Google Scholar 

  • Kimberg DV, Field M, Johnson J, Henderson A, Gershon E (1971) Stimulation of intestinal mucosal adenylate cyclase by cholera enterotoxin and prostaglandins. J Clin Invest 50: 1218–1230

    Article  PubMed  CAS  Google Scholar 

  • Kisloff B, Moore EW (1976) Effects of serotonin on rabbit jejunal and ileal H20 and electrolyte transport. Gastroenterology 70:A-44/902

    Google Scholar 

  • Kisloff B, Moore EW (1977) Effects of intravenous calcitonin on water, electrolyte and calcium movement across in vivo rabbit jejunum and ileum. Gastroenterology 72: 462–468

    PubMed  CAS  Google Scholar 

  • Klee GB, Crouch Th, Richman PG (1980) Calmodulin. Annu Rev Biochem 49: 489–515

    Article  CAS  Google Scholar 

  • Klöppel G, Altenahr E, Menke B (1975) The ultrastructure of focal islet cell adenomatosis in the newborn with hypoglycemia and hyperinsulinism: contributions to the classification of neonatal insulinomas. Virchows Arch [Pathol Anat] 366: 223–236

    Article  Google Scholar 

  • Knappe G, Flemming F, Stobbe H, Wendt F (1966) Pankreasinselzellandenom mit der Trias Diarrhoe, Hypokaliaemie und Hyperglykaemie. Dtsch Med Wochenschr 91: 1224–1228

    Google Scholar 

  • Konturek SJ (1980) Gastrointestinal hormones and gastric secretion. In: Glass GBJ (ed) Gastrointestinal hormones. Raven, New York, p 529

    Google Scholar 

  • Kowlessar OD, Law DH, Sleisenger MH (1959) Malabsorption syndrome associated with metastatic carcinoid tumor. Am J Med 27: 673–677

    Article  PubMed  CAS  Google Scholar 

  • Krejs GJ (1980a) Effect of VIP infusion on ileal water and electrolyte transport in man. Clin Res 28:279 A

    Google Scholar 

  • Krejs GJ (1980b) Effect of VIP infusion on water and ion transport in the human large intestine. Gastroenterology 78: 1200

    Google Scholar 

  • Krejs GJ, Fordtran JS (1980) Effect of VIP infusion on water and ion transport in the human jejunum. Gastroenterology 78: 722–727

    PubMed  CAS  Google Scholar 

  • Krejs GJ, Walsh JH, Morawski SG, Fordtran JS (1977) Intractable diarrhea. Intestinal perfusion studies and plasma VIP concentrations in patients with pancreatic cholera syndrome and surreptitious ingestion of laxatives and diuretics. Am J Dig Dis 27: 280–292

    Google Scholar 

  • Krejs GJ, Browne R, Raskin P (1980) Effect of intravenous somatostatin on jejunal absorption of glucose, amino acids, water, and electrolytes. Gastroenterology 78: 26–31

    PubMed  CAS  Google Scholar 

  • Levant J, Kun TL, Jachna J, Sturdevant RAL, Isenberg JI (1974) The effects of graded doses of C-terminal octapeptide of cholecystokinin on small intestinal transit time in man. Am J Dig Dis 19: 207–209

    Article  PubMed  CAS  Google Scholar 

  • Lezoche E, Vagni V, Speranza V (1978) Elevated vasoactive polypeptide (VIP) levels in patients with the short bowel syndrome ( SBS ). Gastroenterology 74: 1132

    Google Scholar 

  • Lin TM (1980) Pancreatic polypeptide: isolation, chemistry, and biological function. In: Glass GBJ (ed) Gastrointestinal hormones. Raven, New York, p 275

    Google Scholar 

  • Lundqvist G, Krause U, Larsson L-I, Grimelius L, Schaffalitzky de Muckadell OB (1978) A pancreatic polypeptide-producing tumor associated with the WDHA syndrome. Scand J Gastroenterol 13: 715–718

    CAS  Google Scholar 

  • Lundqvist G, Öbery K, Lööf L, Grimelius L, Fahrenkrug J, Bergström H (1980) Hypersecretion of calcitonin in patients with the Verner-Morrison syndrome; effects of treatment with streptozotocin ( Abstr ). Acta Hepato-gastroenterol (Stuttg) [Suppl] p 267

    Google Scholar 

  • Makhlouf GM, Said SI (1975) The effect of VIP an digestive and hormonal function. In: Thompson JC (ed) G I Hormones. University of Texas Press, p 599

    Google Scholar 

  • Marks IN, Bank S, Louw JH (1967) Islet cell tumor of the pancreas with reversible watery diarrhea and achlorhydria. Gastroenterology 52: 695–708

    PubMed  CAS  Google Scholar 

  • Matsumoto KK, Peter JB, Schultze RG, Hakim AA, Franck PT (1966) Watery diarrhea and hypokalemia associated with pancreatic islet cell adenoma. Gastroenterology 50: 231–242

    Google Scholar 

  • Matuchansky C, Bernier J J (1973) Effect of prostaglandin Ex on glucose, water, and electrolyte absorption in the human jejunum. Gastroenterology 64: 1111–1118

    PubMed  CAS  Google Scholar 

  • Matuchansky C, Mary JY, Bernier J J (1972) Effets de la Prostaglandine sur le temps de transit et les mouvements nets et unidirectionels de l’eau et des electrolytes dans le jejunum humain. Biol Gastroenterol (Paris) 5: 175–186

    CAS  Google Scholar 

  • Maynard EP, Point WW (1958) Steatorrhea associated with ulcerogenic tumor of the pancreas. Am J Med 25: 456–459

    Article  PubMed  Google Scholar 

  • McBrien DJ, Jones RV, Creamer B (1963) Steatorrhea in Addison’s disease. Lancet 1: 25

    Article  Google Scholar 

  • Mekhjian H, King DR, Sanzenbacher L, Zollinger R (1972) Glucagon and secretin inhibit water and electrolyte absorption in the human jejunum. Gastroenterology 62: 782

    Google Scholar 

  • Mengel CE (1967) Therapy of malignant carcinoid syndrome. Ann Intern Med 62: 587

    Google Scholar 

  • Misiewicz J J, Waller SL, Eisner M (1966) Motor responses of human gastrointestinal tract to 5-hydroxytryptamine in vivo and in vitro. Gut 7: 208–216

    Article  PubMed  CAS  Google Scholar 

  • Misiewicz J J, Waller S, Horton EW, Kiley N (1969) Effect of oral prostglandin Ei on intestinal transit in man. Lancet 1: 648–651

    Article  PubMed  CAS  Google Scholar 

  • Modigliani R, Mary JY, Bernier J J (1976) Effects of synthetic human gastrin I on movements of water, electrolytes and glucose across the human small intestine. Gastroenterology 71: 978–984

    PubMed  CAS  Google Scholar 

  • Modlin IM, Bloom SR, Mitchell SJ (1978) Experimental evidence for vasoactive intestinal peptide as the cause of the watery diarrhea syndrome. Gastroenterology 75: 1051–1054

    PubMed  CAS  Google Scholar 

  • Moertel CG (1975) Clinical management of advanced gastrointestinal cancer. Cancer 36: 675–682

    Article  PubMed  CAS  Google Scholar 

  • Moertel CG, Hanley JA, Johnson LA (1980) Streptozotocin alone compared with streptozotocin plus fluorouracil in the treatment of advanced islet-cell carcinoma. N Engl J Med 303: 1189–1194

    Article  PubMed  CAS  Google Scholar 

  • Moshal MG, Broitman SA, Zamchek N (1970) Gastrin and absorption. A review. Am J Clin Nutr 23: 336–346

    Google Scholar 

  • Murray JS, Paton RR, Pope (1961) II: pancreatic tumor associated with flushing and diarrhea. Report of a case. N Engl J Med 264: 436–4393

    Google Scholar 

  • Nylander B, Andersson S (1974) Gastric secretory inhibition induced by three methyl analogs of prostaglandin E2 administered intragastrically to man. Scand J Gastroenterol 9: 751–758

    PubMed  CAS  Google Scholar 

  • Nylander B, Robert A, Andersson S (1974) Gastric secretory inhibition by certain methyl analogs of prostaglandin E2 following intestinal administration in man. Scand J Gastroenterol 9: 759–762

    PubMed  CAS  Google Scholar 

  • Pandol SJ, Korman LY, McCarthy DM, Gardner JD (1980) Beneficial effect of oral lithium carbonate in the treatment of pancreatic cholera syndrome. N Engl J Med 302: 1403–1404

    Article  PubMed  CAS  Google Scholar 

  • Parks DL, Gingerich RL, Jaffe BM, Akande B (1979) Role of PP in canine gastric acid secretion. Am J Physiol 236: E 488–E 494

    Google Scholar 

  • Patel GK, Whalen GE, Soergel KH, Wu WC, Meade RC (1979) Glucagon effects on the human small intestine. Am J Dig Dis 24: 501–508

    Article  CAS  Google Scholar 

  • Pearse AGE (1968) Common cytochemical and ultrastructural characteristics of cells producing polypeptide hormones (the APUD series) and their relevance to thyroid and ultimobranchial C cells and calcitonin. Proc R Soc Lond B Biol Sei 170: 71–80

    Article  CAS  Google Scholar 

  • Pearse AGE (1975) Neurocristopathy, neuroendocrine pathology and the APUD concept. Z Krebs- forsch 84: 1–18

    Article  CAS  Google Scholar 

  • Peterson HD, Collins OD (1967) Chronic diarrhea and failure to thrive secondary to ganglioneuroma. Arch Surg 95: 934–936

    PubMed  CAS  Google Scholar 

  • Pierce NF, Carpenter CCJ, Elliott HL, Greenough WB (1971) Effects of prostaglandins, theophyllin, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum. Gastroenterology 60: 22–32

    PubMed  CAS  Google Scholar 

  • Priest WM, Alexander MK (1957) Islet cell tumor of the pancreas with peptic ulceration, diarrhea and hypokalemia. Lancet 2: 1145–1147

    Article  Google Scholar 

  • Pytkowski B (1979) On the contribution of prostaglandin-like substances to the action of bradykinin on intestinal motility and blood flow. Eur J Clin Invest 9: 391–396

    Article  PubMed  CAS  Google Scholar 

  • Rabbani GH, Greenough WB, Holmgren, Lönnroth (1979) Chlorpromazine reduces fluid loss in cholera. Lancet 1: 410–412

    Article  PubMed  CAS  Google Scholar 

  • Racusen LC, Binder HJ (1977) Alteration of large intestinal electrolyte transport by vasoactive intestinal peptide in the rat. Gastroenterology 73: 790–796

    PubMed  CAS  Google Scholar 

  • Rambaud J-C, Modigliani R, Matuchansky C, Bloom S, Said S, Pessayre D, Bernier J J (1975) Pancreatic cholera-studies on tumoral secretions and pathophysiology of diarrhea. Gastroenterology 69: 110–122

    PubMed  CAS  Google Scholar 

  • Read NW, Krejs GJ, Read MG, Santa Ana CA, Morawski SG, Fordtran JS (1980) Chronic diarrhea of unknown origin. Gastroenterology 78: 268–271

    Google Scholar 

  • Robert A, Nezamis JE, Phillips JP (1967) Inhibition of gastric secretion by prostaglandins. Am J Dig Dis 12: 1073–1076

    Article  PubMed  CAS  Google Scholar 

  • Robert A, Nezamis JE, Phillips JP (1968) Effect of prostaglandin on gastric secretion and ulcer formation in the rat. Gastroenterology 55: 481–487

    PubMed  CAS  Google Scholar 

  • Rudo ND, Rosenberg IH (1973) Chronic glucagon administration enhances intestinal transport in the rat. Proc Soc Exp Biol Med 142: 521–525

    PubMed  CAS  Google Scholar 

  • Ruppin H, Domschke W (1980) Gastrointestinal hormones and motor function of the gastrointestinal tract. In: Glass GBJ (ed) Gastrointestinal hormones. Ravens, New York, p 587

    Google Scholar 

  • Ruppin H, Sturm G, Westhoff D, Domschke S, Domschke W, Wünsch E, Demling L (1976) Effect of 13-nle-motilin on small intestinal transit time in healthy subjects. Scand J Gastroenterol Suppl 39, 11: 85–88

    PubMed  CAS  Google Scholar 

  • Ruppin H, Soergel KH, Dodds JW, Wood CM, Domschke W (1979) Effects of the interdigestive motor complex (IMC) and 13-norleucine motilin ( NLEM) on fasting intestinal flow rate and velocity in man. Gastroenterology 76: 1231

    Google Scholar 

  • Rüssel R (1967) Hypoparathyroidism and malabsorption. Br Med J 3: 781–782

    Article  Google Scholar 

  • Said SI, Mutt V (1970) Polypeptide with broad biological activity: isolation from small intestine. Science 169: 1217–1218

    Article  PubMed  CAS  Google Scholar 

  • Said SI, Faloona GR (1975) Elevated plasma and tissue levels of vasoactive intestinal polypeptide in the watery-diarrhea syndrome due to pancreatic, bronchogenic and other tumors. N Engl J Med 293: 155–160

    Article  PubMed  CAS  Google Scholar 

  • Sandler M, Karim SMM, Williams ED (1968) Prostaglandins in amine-peptide secreting tumors. Lancet 2: 1053–1055

    Article  PubMed  CAS  Google Scholar 

  • Schein PS, DeLellis RA, Kahn CR (1973a) Islet cell tumors: current concepts and management. Ann Intern Med 79: 239–257

    PubMed  CAS  Google Scholar 

  • Schein PS, Kahn R, Gordon P, Wells S, De Vita VT (1973 b) Streptozotocin for malignant insulinomas and carcinoid tumor: report of eight cases and review of the literature. Arch Intern Med 132: 555–561

    Google Scholar 

  • Schmitt MG, Soergel KH, Hensley GT, Chey WY (1975) Watery diarrhea associated with pancreatic islet cell carcinoma. Gastroenterology 69: 206–216

    PubMed  Google Scholar 

  • Schwartz CJ, Kimberg DV, Sheerin HE, Field M, Said SI (1974) Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa. J Clin Invest 54: 536–544

    Article  PubMed  CAS  Google Scholar 

  • Schwartz SE, Fitzgerald MA, Levine RA, Schwartzel EH (1978) Normal jejunal cyclic nucleotide content in a patient with secretory diarrhea. Arch Intern Med 138: 1403–1405

    Article  PubMed  CAS  Google Scholar 

  • Schwartz TW (1979) Pancreatic-polypeptide (PP) and endocrine tumours of the pancreas. Scand J Gastroenterol 53: 93–100

    CAS  Google Scholar 

  • Shafram I (1976) Nutmeg toxicology. N Engl J Med 294: 849

    Google Scholar 

  • Simon B, Kather H (1980) Human colonic adenylate cyclase. Stimulation of enzyme activity by vasoactive intestinal peptide and various prostaglandins via distinct receptor sites. Digestion 20: 62–67

    Google Scholar 

  • Smith AN, Hogg D (1966) Effect of gastrin II on the motility of the gastrointestinal tract. Lancet 1: 403–404

    Article  PubMed  CAS  Google Scholar 

  • Smith PL, Field M (1980) In vitro antisecretory effects of trifluoperazine and other neuroleptics in rabbit and human small intestine. Gastroenterology 78: 1545–1553

    PubMed  CAS  Google Scholar 

  • Soergel KH, Bjork JT, Wood CM (1981) The WDHA syndrome: no correlation between clinical course, plasma hormone levels, and small intestinal function. In: Ruppin H, Domschke W, Soergel KH (eds) Diarrhea in disorders of intestinal transport. Thieme, Stuttgart, p 143

    Google Scholar 

  • Stadil F (1980) Gastrinomas. In: Glass GBJ (ed) Gastrointestinal hormones. Raven, New York, p 729

    Google Scholar 

  • Swift PGF, Bloom SR, Harris F (1975) Watery diarrhoea and ganglioneuroma with secretion of vasoactive intestinal peptide. Arch Dis Child 50: 896–899

    Article  PubMed  CAS  Google Scholar 

  • Tai HH, Chey WY, Escoffery RG, Hendricks J (1976) Diarrheic factors in non-beta islet cell tumor of the pancreas. Clin Res 24:292 A

    Google Scholar 

  • Verner JV, Morrison AB (1958) Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. Am J Med 25: 374–380

    Article  PubMed  CAS  Google Scholar 

  • Verner JV, Morrison AB (1974) Non-B islet cell tumors and the syndrome of watery diarrhea, hypokalemia and achlorhydria. Clin Gastroenterol 3: 595–608

    Google Scholar 

  • Waldman DB, Gardner JD, Zfass AM, Makhlouff GM (1977) Effects of vasoactive intestinal peptide, secretin, and related peptides on rat colonic transport and adenylate cyclase. Gastroenterology 74: 513–523

    Google Scholar 

  • Walsh JH (1978) Pancreatic cholera and related syndromes. In: Sleisenger MH, Fordtran JS (eds) Gastrointestinal disease. Saunders, Philadelphia London Toronto, p 1496

    Google Scholar 

  • Williams ED, Karim SMM, Sandler M (1968) Prostaglandin secretion by medullary carcinoma of the thyroid. Lancet 1: 22–23

    Article  PubMed  CAS  Google Scholar 

  • Wilson SD, Soergel K, Go VLW (1973) Diarrhoea, gastric hypersecretion and “cholecystokinin-like” hormone. Lancet 1: 1515–1516

    Article  PubMed  CAS  Google Scholar 

  • Wingate DL, Pearce EA (im Druck) The physiological role of glucagon in the digestive tract. In: Picazo J (ed) Glucagon in gastroenterology. MTP Press, Lancaster

    Google Scholar 

  • Zollinger RM, Ellison EH (1955) Primary peptic ulceration of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 142: 709–728

    Article  PubMed  CAS  Google Scholar 

  • Zollinger RM, Tompkins RK, Amerson JR, Endahl GL, Kraft AR, Moore FT (1968) Identification of the diarrheagenic hormone associated with non-beta islet cell tumors of the pancreas. Ann Surg 168: 502–518

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. Ruppin
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  2. K. H. Soergel
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  1. Medizinische Klinik II, Stadtkrankenhaus, Leimenstr. 20, D-6450, Hanau 1, Germany

    W. F. Caspary

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Ruppin, H., Soergel, K.H. (1983). Hormonell induzierte Diarrhöen. In: Bommer, W., et al. Dünndarm B. Handbuch der inneren Medizin, vol 3 / 3 / B. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68897-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-68897-3_11

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