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Endokrine Tumoren des Dünndarms

  • Chapter
Dünndarm B

Part of the book series: Handbuch der inneren Medizin ((INNEREN 3,volume 3 / 3 / B))

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Zusammenfassung

Als Karzinoide (Oberndorfer 1907) bezeichnet man epitheliale, häufig hor-monaktive Tumoren, die sich von den Zellen des diffusen, endokrinen Systems in den Organen des embryonalen Darmrohrs vom Kiemen- bis zum Enddarm (Williams U. Sandler 1963) aber auch im Urogenitaltrakt ableiten (Williams et al. 1980). Da diese Tumoren ein unterschiedliches Spektrum endokriner oder biochemischer Aktivität aufweisen, ist der Begriff Karzinoid im wesentlichen morphologisch charakterisiert (Soga 1976). Er wird durch histochemische, biochemische und immunhistologische Methoden weiter präzisiert.

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Literatur

  • Allison D, Modlin IM, Jenkins WJ (1977) Treatment of carcinoid liver metastases by hepatic artery embolization. Lancet II: 1323–1325

    Google Scholar 

  • Alumets J, Hakanson R, Ingemansson S, Sundler F (1977) Substance P and 5-HT in granules isolated from intestinal argentaffin carcinoid. Histochemistry 52: 217–222

    PubMed  CAS  Google Scholar 

  • Alumets J, Ekelund G, Hakanson R, Ljungberg O, Ljungqvist U, Sundler F, Tibblin S (1978) Jejunal endocrine tumour composed of somatostatin and gastrin cells and associated with duodenal ulcer disease. Virchow Arch A Pathol Anat Histol 378: 17–22

    CAS  Google Scholar 

  • Anthony PP (1970) Gangrene of the small intestine - a complication of argentaffin carcinoma. Br J Surg 57: 118–122

    PubMed  CAS  Google Scholar 

  • Anthony PP, Drury RAB (1970) Elastic vascular sclerosis of mesenteric blood vessels in argentaffin carcinoma. J Clin Pathol 23: 110–118

    PubMed  CAS  Google Scholar 

  • Antonson S, Hansen MGJ, Burkhave K, Rask-Madsen J (1982) Influence of a new selective 5-HT2 receptor antagonist (ketanserin) on jejunal PGE2 release and ion secretion due to malignant carcinoid syndrome. Gut 23: A884

    Google Scholar 

  • Axelson S, Björklund A, Falck B, Lindvall O, Svensson LA (1973) Glyoxylic acid condensation: A new fluorescence method for the histochemical demonstration of biogenic monoamines. Acta Physiol Scand 87: 57–62

    Google Scholar 

  • Baca I, Junghanns KH, Feurle GE, Hoevels J (1982) Gastrinom der Duodenalwand. Akt Chir 17: 125–126

    Google Scholar 

  • Barclay GPT, Robb WAT (1968) A clinicopathologic study of carcinoid tumors. Surg Gynecol Obstet 126: 483–496

    PubMed  CAS  Google Scholar 

  • Barter R, Pearse AGE (1953) Detection of 5-hydroxytryptamine in mammalian enterochromaffin cells. Nature 172: 810

    PubMed  CAS  Google Scholar 

  • Becker V, Kümmerle F, Schlier J, Lenner V, Londong W (1976) Tumoren des endokrinen Pankreas. In: Forell MM (Hrsg) Handbuch der inneren Medizin III, Teil 6. S 1042–1104

    Google Scholar 

  • Bennett A, Eley KG, Scholes GB (1968) Effects of prostaglandins Ex and E2 on human guinea-pig and rat isolated small intestine. Br J Pharmacol 34: 630–638

    PubMed  CAS  Google Scholar 

  • Bhoola KD, Collier HOJ, Schachter M, Shorley PG (1962) Actions of some peptides on bronchial muscle. Br J Pharmacol 19: 190–197

    CAS  Google Scholar 

  • Bisset GW, Lewis GP (1962) A spectrum of pharmacological activity in some biologically active peptides. Br J Pharmacol 19: 168–182

    CAS  Google Scholar 

  • Bivens CH, Marecek RL, Feldmann JM (1973) Peyronie’s disease - a presenting complaint of the carcinoid syndrome. N Engl J Med 289: 844–845

    PubMed  CAS  Google Scholar 

  • Björklund A, Falck B, Hakansson R (1968) Histochemical demonstration of tryptamine. Properties of the formaldehyde-induced fluorophores of tryptamine and related indole compounds in models. Acta Physiol Scand [Suppl] 318: 1–31

    Google Scholar 

  • Black WC III (1968) Enterochromaffin cell types and corresponding carcinoid tumors. Lab Invest 19: 473–486

    PubMed  Google Scholar 

  • Büchler MW (1981) Strukturanalyse des Meckelschen Divertikels unter besonderer Berücksichtigung der endokrinen Zellen. In: Doerr W, Leonhardt H (Hrsg) Normale und pathologische Anatomie. Thieme, Stuttgart New York

    Google Scholar 

  • Bukhave K, Rask-Madsen J (1979) Prostaglandins and chronic diarrhoea: Methodological problems. Scand J Gastroenterol [Suppl 53] 14: 67–71

    CAS  Google Scholar 

  • Bukhave K, Rask-Madsen J (1980) Saturation kinetics applied to in vitro effects of low prostaglandin E2 and F2 concentrations onion transport across human jejunal mucosa. Gastroenterology 78: 32–42

    PubMed  CAS  Google Scholar 

  • Carter SK, Broder LE (1974) The cytostatic therapy of hormone-secreting tumours of the gastrointestinal tract. Clin Gastroenterol 3: 733–745

    Google Scholar 

  • Casella C, Reggiani M (1946) Spettro di fluorescenza delle cellule enterochromaffini di cavia. Boll Soc Ital Biol Sper 22: 480–481

    Google Scholar 

  • Cassidy MA (1931) Abdominal carcinomatosis with probable adrenal involvement. Proc Roy Soc Med 24: 139–141

    Google Scholar 

  • Collatz Christensen S, Stage JG, Henriksen FW (1979) Angiography in the diagnosis of carcinoid syndrome. Scand J Gastroenterol [Suppl 53] 14: 111–114

    Google Scholar 

  • Comroe JH, Van Lingen B, Stroud RC, Roncoroni A (1953) Reflex and direct cardiopulmonary effects of 5-OH-tryptamine (serotonin). Their possible role in pulmonary embolism and coronary thrombosis. Am J Physiol 173: 379–384

    Google Scholar 

  • Coons AH, Leduc EH, Conolly JM (1955) Studies on antibody production. 1. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J Exp Med 102: 49–60

    Google Scholar 

  • Corrodi H, Jonsson G (1967) The formaldehyde fluorescence method for the histochemical demonstration of biogenic monoamines. A review on the methodology. J Histochem Cytochem 15: 67–78

    Google Scholar 

  • Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS (1975) Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas ( Zollinger-Ellison syndrome ). Hum Pathol 6: 47–76

    Google Scholar 

  • Cuello AC, Wells C, Chaplin AJ, Milstein C (1982) Serotonin immunoreactivity in carcinoid tumours demonstrated by a monoclonal antibody. Lancet 1: 771–773

    PubMed  CAS  Google Scholar 

  • Damgaard-Petersen K, Stage JG (1979) CT Scanning in Patients with Zollinger-Ellison Syndrome and Carcinoid Syndrome. Scand J Gastroenterol [Suppl 53] 14: 117–122

    Google Scholar 

  • Davis Z, Moertel CG, Mcllrath DC (1973) The malignant carcinoid syndrome. Surg Gynecol Obstet 137: 637–644

    PubMed  CAS  Google Scholar 

  • Degkwitz R, Frowein R, Kirberger E, Kuhlenkampff C, Mohs U (1962) Über Normalwerte der stündlichen 5-HIES-Ausscheidung im Urin beim Menschen und die Messungen störende Faktoren. Klin Wochenschr 40: 285–289

    PubMed  CAS  Google Scholar 

  • Dery R (1971) Theoretical and clinical considerations in anaesthesia for secreting carcinoid tumors.Can Anaesthet Soc 18: 245–263

    CAS  Google Scholar 

  • Dharmsathaphorn K, Sherwin RS, Cataland S, Jaffe B, Dobbins J (1980) Somatostatin inhibits diarrhea in the carcinoid syndrome. Ann Intern Med 92: 68–69

    PubMed  CAS  Google Scholar 

  • Diffenbaugh WG, Anderson RE (1956) Carcinoid (argentaffin) tumors of the gastrointestinal tract. Arch Surg 73: 21–37

    CAS  Google Scholar 

  • Duner H, Pernow B (1960). Circulatory studies on substance P in man. Acta Physiol Scand 49: 261–266

    PubMed  CAS  Google Scholar 

  • Ehinger B, Thunberg R (1967) Induction of fluorescence in histamine-containing-cells. Exp Cell Res 47: 116–122

    PubMed  CAS  Google Scholar 

  • Engelman K, Lovenberg W, Sjoerdsma A (1967) Inhibition of serotonin synthesis by para-chlorophe-nylalanine in patients with the carcinoid syndrome. N Engl J Med 277:1103–1108 Eränkö O (1951) On the histochemistry of the rat adrenal medulla. Acta Physiol Scand [Suppl 89] 25: 22–23

    Google Scholar 

  • Erspamer V, Asero B (1952) Identification of enteramine, the spezific hormone of the enterochromaf-fine cell system, as 5-hydroxy-tryptamine. Nature 169: 800–801

    PubMed  CAS  Google Scholar 

  • Eschbach JW, Rinaldo JA (1962) Metastatic carcinoid: A familial occurrence. Ann Intern Med 57: 647–650

    Google Scholar 

  • Falck B (1962) Observations on possibilities of the cellular localisation of monoamines by a fluorescence method. Acta Physiol Scand 56 Supp 197: 1–25

    Google Scholar 

  • Feldman JM (1978) Serotonin metabolism in patients with carcinoid tumors: incidence of 5-hydroxy-tryptophan-secreting tumors. Gastroenterology 75: 1109–1114

    PubMed  CAS  Google Scholar 

  • Feurle GE, Helmstädter V, Hoevels J, Wenzel-Herzer E, Klempa I (1982) Wandel von Diagnose und Therapie beim Zollinger-Ellison-Syndrom. Dtsch Med Wochenschr 107: 697–704

    PubMed  CAS  Google Scholar 

  • Feyrter F (1932) Carcinoid und Carcinom. Ergeb Pathol 29: 305–489

    Google Scholar 

  • Feyrter F (1953) Uber die peripheren endokrinen (parakrinen) Drüsen des Menschen. Maudrich, Wien Düsseldorf

    Google Scholar 

  • Feyrter F (1962) Über die peripheren endokrinen (parakrinen) Drüsen und ihre Geschwülste, insbesondere das enterale und das bronchiale Karzinoid. Verh Dtsch Ges Inn Med 68: 161–182

    Google Scholar 

  • Fleischmajer R, Hyman AB (1961) Clinical significance of derangements of tryptophan metabolism. Arch Dermatol 84: 563–573

    PubMed  CAS  Google Scholar 

  • Fröhlich JC, Bloomgarden ZT, Oates JA, McGuigan JE, Rabinowitz D (1978) The carcinoid flush Provocation by pentagastrin and inhibition by somatostatin. N Engl J Med 299: 1055–1057

    Google Scholar 

  • Funk HU, Hardmeier T, Hedinger C (1965) Zur Beurteilung der Dignität intestinaler Carcinoide. Z Krebsforsch 67: 278–288

    Google Scholar 

  • Gamse R, Saria A, Bucsics A, Lembeck F (1981) Substance P in tumors: pheochromocytoma and carcinoid. Peptides [Suppl 2] 2: 275–280

    Google Scholar 

  • Ganda OP, Weir GC, Soeldner JS, Legg MA, Chick WL, Patel YC, Ebeid AM, Gabbay KH, Reichlin S (1977) „Somatostatinoma“A Somatostatin-containing tumor of the endocrine pancreas. N Engl J Med 296: 963–967

    Google Scholar 

  • Geffroy Y, Laumonier R, Matray F (1967) Les tumeurs carcinoides de l’intestine grele. Rev Prat (Paris) 17: 727–745

    Google Scholar 

  • Godwin JD (1975) Carcinoid tumors. An Analysis of 2837 cases. Cancer 36: 560–569

    PubMed  Google Scholar 

  • Goedert M, Otten U, Suda K, Heitz PU, Stalder GA, Obrecht JP, Holzach P, Allgöwer M (1980) Dopamine, norepinephrine and serotonin production by an intestinal carcinoid tumor. Cancer 45: 104–107

    PubMed  CAS  Google Scholar 

  • Gösset A, Masson P (1914) Tumeurs endocrines de l’appendice. Presse Med 22: 237–240

    Google Scholar 

  • Grahame-Smith DG (1964) Tryptophan hydroxylation in carcinoid tumors. Biochem Biophys Acta 86: 176–179

    PubMed  CAS  Google Scholar 

  • Grahame-Smith DG (1972) The carcinoid syndrome. Heinemann London Green D, Joynt RJ, van Allen MV (1964) Neuromyopathy associated with a malignant carcinoid tumor. Arch Intern Med 114: 494–496

    Google Scholar 

  • Grimelius L (1968) A silver nitrate stain for a2-cells in human pancreatic islets. Acta Soc Med Uppsal 73: 243–276

    CAS  Google Scholar 

  • Grimelius L (1969) An electron microscopic study of silver stained adult human pancreatic islet cells, with reference to a new silver nitrate procedure. Acta Soc Med Uppsal 74: 28–48

    CAS  Google Scholar 

  • Hakanson R, Bengmark S, Brodin E, Ingemansson S, Larsson LI, Nilsson G, Sundler F (1977) Substance P-like immunoreactivity in intestinal carcinoid tumors. In: Euler US, Pernow B (eds) Substance P. Raven, New York, pp 55–58

    Google Scholar 

  • Hales CA, Mark EJ (1981) Exertional dyspnoea, cough, and hepatomegaly in a 58 year old man. N Engl J Med 304: 1350–1356

    Google Scholar 

  • Hamperl H (1932) Was sind argentaffine Zellen? Virchows Arch Pathol Anat 286: 811–833

    Google Scholar 

  • Hanna SM (1965) Carcinoid syndrome associated with psychosis. Postgrad Med J 41: 566–567

    PubMed  CAS  Google Scholar 

  • Hedinger C (1959) Karzinoidsyndrom. Schweiz Med Wochenschr 52:1362–1364 Hedinger C (1972) Karzinoide des Verdauungstrakts. Helv Chir Acta 40: 701–713

    Google Scholar 

  • Hegglin R, Zollinger H (1956) Klinisch-pathologisch-anatomische Demonstrationen ( Mitralstenose, Libman-Sacks-Syndrom und metastasierendes Dünndarmkarzinoid). Cardiologia 28: 151–167

    Google Scholar 

  • Heidenhain R (1870) Untersuchungen über den Bau der Labdrüsen. Arch Mikroskop Anat 6: 368 – 406

    Google Scholar 

  • Heitz P, Polak JM, Timson CM, Pearse AGE (1976) Enterochromaffin cells as the endocrine source of gastrointestinal substance. P. Histochemistry 49: 343–347

    CAS  Google Scholar 

  • Herkheimer H (1953) Further observations on the influence of 5-hydroxytryptamine on bronchial function. J Physiol (Lond) 122: 49P–50 P

    Google Scholar 

  • Höfler H, Auböck L, Ratzenhofer M (1982) Neurogene Appendicopathie - eine facultative Vorerkrankung des Appendixcarcinoids. In: Doerr W, Leonhardt H (Hrsg) Normale und pathologische Anatomie, vol 45. Thieme, Stuttgart New York

    Google Scholar 

  • Hofmann JW, Fox PS, Wilson SD (1973) Duodenal wall tumors and the Zollinger-Ellison syndrome. Arch Surg 107: 334–339

    PubMed  CAS  Google Scholar 

  • Horton EW, Main IHM, Thompson CJ, Wright PM (1968) Effect of orally administered Prostaglan¬din Ex on gastric secretion and gastrointestinal motility in man. Gut 9: 655–658

    PubMed  CAS  Google Scholar 

  • Huebschmann P (1910) Sur le carcinome primitif de l’appendice vermiculaire. Rev Med Suisse Rom 30: 317–332

    Google Scholar 

  • Hui K, Reza MJ, Busuttil RW (1978) An unusual cause of massive gastrointestinal hemorrhage. JAMA 239: 2690–2691

    PubMed  CAS  Google Scholar 

  • Hunt RH, Dilawari JB, Misiewicz JJ (1975) The effect of intravenous prostaglandins F2a and E2 on the motility of the sigmoid colon. Gut 16: 47–49

    PubMed  CAS  Google Scholar 

  • Ingemansson S, Larsson LI, Lunderqvist A, Stadil F (1977) Pancreatic vein catheterization with gastrin assay in normal patients and in patients with the Zollinger-Ellison syndrome. Am J Surg 134: 558–563

    PubMed  CAS  Google Scholar 

  • Isler P, Hedinger C (1953) Metastasierendes Dünndarmcarcinoid mit schweren, vorwiegend das rechte Herz betreffenden Klappenfehlern und Pulmonalstenose - ein eigenartiger Symptomenkomplex? Schweiz Med Wochenschr 83: 4–7

    PubMed  CAS  Google Scholar 

  • Jaffe BM (1979) Prostaglandins and serotonin: Nonpeptide diarrheogenic hormones. World J Surg 3: 565–577

    PubMed  CAS  Google Scholar 

  • Jaffe BM, Condon S (1976) Prostaglandins E and F in endocrine diarrheagenic syndromes. Ann Surg 184: 516–524

    CAS  Google Scholar 

  • Jepson JB (1955) Paper chromatography of urinary indoles. Lancet 11: 1009–1011

    Google Scholar 

  • Jouanneau P, Malafosse M (1971) Le tumeurs carcinoides du tube digestif. Masson, Paris

    Google Scholar 

  • Kähler HJ (1967) Das Karzinoid. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Kähler HJ (1968) Laboratoriumsbefunde beim Karzinoidsyndrom. Dtsch Med Wochenschr 93: 959–961

    PubMed  Google Scholar 

  • Kähler HJ, Heilmeyer L (1961) Klinik und Pathophysiologic des Karzinoids und Karzinoidsyndroms unter besonderer Berücksichtigung der Pharmakologie des 5-Hydroxytryptamins. Ergeb Inn Med Kinderheilk 16: 291–559

    Google Scholar 

  • Kaneko H, Yanaihara N, Ito S, Kusumoto Y, Fujita T, Ishikawa S, Sumida T, Sekiya M (1979) Somatostatinoma of the duodenum. Cancer 44: 2273–2279

    PubMed  CAS  Google Scholar 

  • Kaude JV (1973) Calcification of carcinoid tumors. N Engl J Med 289: 921

    PubMed  CAS  Google Scholar 

  • Kisloff B, Moore EW (1976) Effect of serotonin on water and electrolyte transport in vivo rabbit small intestine. Gastroenterology 71: 1033–1038

    PubMed  CAS  Google Scholar 

  • Kowlessar OD, Law DH, Sleisenger MH (1959) Malabsorption syndrome associated with metastaticcarcinoid tumor. Am J Med 27:673–677

    Google Scholar 

  • Kultschitzky N (1897) Zur Frage über den Bau des Darmkanals. Arch Mikroskop Anat 49: 7–35

    Google Scholar 

  • Lachapelle JM, Philippart JL, Tennstedt D, Balthazar E (1977) Syndrome carcinoide: Manifestations cutanées chroniques florides. Ann Derm Vénéréol (Paris) 104: 66–67

    Google Scholar 

  • Lanfranchi J, Morand P, Groussien P (1972) Le cardiopathies carcinoides. Ann Cardiol Angiol 21: 183–192

    CAS  Google Scholar 

  • Langhans T (1867) Über einen Drüsenpolyp im Ileum. Arch Pathol Anat 38: 559–560

    Google Scholar 

  • Larsson LI, Hirsch MA, Holst JJ, Ingemansson S, Kühl C, Jensen SL, Lundqvist G, Rehfeld JF, Schwartz TW (1977) Pancreatic Somatostatinoma. Clinical features and physiological implications. Lancet 1: 666–668

    Google Scholar 

  • Legha SS, Valdivieso M, Nelson RS, Benjamin RS, Bodey GP (1977) Chemotherapy for metastatic carcinoid tumors: Experiences with 32 patients and review of the literature. Cancer Treat Rep 61: 1699–1703

    PubMed  CAS  Google Scholar 

  • Lembeck F (1953) 5-hydroxytryptamine in a carcinoid tumor. Nature (London) 172:910–911

    Google Scholar 

  • Lembeck F (1962) Biochemie und Pharmakologie der Carzinoide. Verh Dtsch Ges Med 68:194–211 Levine RJ, Sjoerdsma A (1963) Pressor amines and the carcinoid flush. Ann Intern Med 58: 818–828

    Google Scholar 

  • Liljedahl SO, Mattsson O and Pernow B (1958) Effect of substance P on intestinal motility in man. Scand J Clin Lab Invest 10: 16–25

    PubMed  CAS  Google Scholar 

  • Linell F, Mansson K (1966) On the prevalence and incidence of carcinoids in Malmö. Acta Med Scand [Suppl] 445: 377–382

    CAS  Google Scholar 

  • Long RG, Peters JR, Bloom SR, Brown MR, Vale W, Rivier JE, Grahame-Smith DG (1981) Somatostatin, gastrointestinal peptides, and the carcinoid syndrome. Gut 22: 549–553

    PubMed  CAS  Google Scholar 

  • Lubarsch O (1888) Über den primären Krebs des Ileum nebst Bemerkungen über das gleichzeitige Vorkommen von Krebs und Tuberkulose. Arch Pathol Anat 111: 280–317

    Google Scholar 

  • Lunderquist A, Ericsson M, Nobin A, Sandén G (1982) Gelfoam powder emolization of the hepatic artery in liver metastases of carcinoid tumors. Radiologe 22: 65–70

    PubMed  CAS  Google Scholar 

  • Lundqvist M, Wilander E (1981) Somatostatin-like immunoreactivity in mid-gut carcinoids. Acta Path Microbiol Scand Sect A 89: 335–337

    CAS  Google Scholar 

  • Luse SA, Lacy PE (1960) Electron microscopy of a malignant argentaffin tumor. Cancer 13: 334–346

    Google Scholar 

  • McCarthy DM (1980) The place of surgery in the Zollinger-Ellison syndrome. N Engl J Med 302: 1344–1347

    PubMed  CAS  Google Scholar 

  • MacDonald RA (1956) A study of 365 carcinoids of the gastrointestinal tract. Am J Med 21: 867–878

    PubMed  CAS  Google Scholar 

  • McKusick VA (1956) Carcinoid cardiovascular disease. Bull Johns Hopkins Hosp 98: 13–36

    PubMed  CAS  Google Scholar 

  • Mallinson CN, Bloom SR, Warin AP, Salmon PR, Cox B (1974) A glucagonoma syndrome. Lancet II: 1–5

    Google Scholar 

  • Marks C (1979) Carcinoid tumors. Hall, Boston, Mass. USA

    Google Scholar 

  • Martin RG (1970) Management of carcinoid tumors. Cancer 26: 547–551

    PubMed  CAS  Google Scholar 

  • Mason RA, Steane PA (1976) Carcinoid syndrome: its relevance to the anesthetist. Anesthesia 31: 228–242

    CAS  Google Scholar 

  • Matuchansky C, Bernies JJ (1973) Effect of prostaglandin Et on glucose, water, and electrolyte absorption in the human jejunum. Gastroenterology 64: 1111–1118

    PubMed  CAS  Google Scholar 

  • Melmon K, Lovenberg W, Sjoerdsma A (1965a) Identification of lysyl-bradykinin as the peptide formed in vitro by carcinoid tumour kallikrein. Clin Chem Acta 12: 292–297

    CAS  Google Scholar 

  • Melmon KL, Sjoerdsma A, Oates JA, Laster L (1965) Treatment of malabsorption and diarrhea of the carcinoid syndrome with methysergide. Gastroenterology 48: 18–24

    PubMed  CAS  Google Scholar 

  • Mengel CE (1963) Cutaneous manifestations of the malignant carcinoid syndrome. Ann Intern Med 58: 989–993

    Google Scholar 

  • Mengel CE (1965) Therapy of the malignant carcinoid syndrome. Ann Intern Med 62: 587–602

    PubMed  CAS  Google Scholar 

  • Mengel CE, Lotito CA (1968) A new antiserotonin in the carcinoid syndrome. Arch Intern Med 121: 507–510

    PubMed  CAS  Google Scholar 

  • Methfessel HD, Bettziesche H, Methfessel G (1973) Schwangerschaft und Geburt bei Appendixkarzi-noid mit familiärer Disposition. Zbl Gynaekol 95: 234–238

    CAS  Google Scholar 

  • Meves M, Abdelhamid S, Wollenweber J (1982) Die Embolisation der Arteria hepatica zur Behandlung des Karzinoid-Syndroms. Z Gastroenterologie 20: 438–447

    CAS  Google Scholar 

  • Misiewicz JJ, Waller SL, Eisner M (1966) Motor responses of human gastrointestinal tract to 5-hydroxytryptamine in vivo and in vitro. Gut 7: 208–216

    PubMed  CAS  Google Scholar 

  • Misiewicz JJ, Waller SL, Kiley N, Horton EW (1969) Effect of oral prostaglandin Ei on intestinal transit time in man. Lancet 1: 648–651

    PubMed  CAS  Google Scholar 

  • Moertel CG, Sauer WG, Dockerty MB, Baggenstoss AH (1961) Life history of the carcinoid tumor of the small intestine. Cancer 14: 901–912

    PubMed  CAS  Google Scholar 

  • Mustala O.O., Tuomisto JJ, Airaksinen MM (1964) A new modification for the determination of 5-hydroxyindole-acetic acid (5-HIAA) in urine. Scand J Clin Lab Invest 16: 655–660

    PubMed  CAS  Google Scholar 

  • Nash DT, Brin M (1964) Malabsorption in malignant carcinoid with normal 5 HIAA. NY St J Med 64: 1128–1131

    CAS  Google Scholar 

  • Oates JA, Butler TC (1967) Pharmacologic and endocrine aspects of carcinoid syndrome. Adv Pharmacol 5: 109–128

    PubMed  CAS  Google Scholar 

  • Oates JA, Sjoerdsma A (1962) A unique syndrome associated with secretion of 5-hydroxytryptophan by metastatic gastric carcinoids. Am J Med 32: 333–342

    PubMed  CAS  Google Scholar 

  • Oates JA, Melmon K, Sjoerdsma A, Gillespie L, Mason DT (1964) Release of a kinin peptide in the carcinoid syndrome. Lancet 1: 514–517

    PubMed  CAS  Google Scholar 

  • Oates JA, Pettinger WA und Doctor RB (1966) Evidence for the release of bradykinin in carcinoid syndrome. J Clin Invest 45: 173–178

    CAS  Google Scholar 

  • Oberndorfer S (1907) Karzinoide Tumoren des Dünndarms. Frankf Z Pathol 1: 426–432

    Google Scholar 

  • Otten MH, Birkenhaeger JC, van Blankenstein M (1978) Zollinger-Ellison syndrome treated by endoscopical removal of a duodenal gastrinoma. Neth J Med 21: 248–251

    PubMed  CAS  Google Scholar 

  • Pearse AGE (1972) Histochemistry. Theoretical and applied, vol II, 3rd ed. Churchill Livingstone, Edinburgh London

    Google Scholar 

  • Pearse AGE, Polak JM (1975) Immunocytochemical localization of substance P in mammalian intestine. Histochemistry 41: 373–375

    PubMed  CAS  Google Scholar 

  • Peavy PW, Rogers JV, Clements JL, Burns JB (1973) Unusual osteoplastic metastases from carcinoid tumors. Radiology 107: 327–330

    PubMed  CAS  Google Scholar 

  • Peiper HJ, Creutzfeldt W (1975) Endokrine Tumoren des Gastrointestinaltraktes. Chirurg 46: 194–203

    PubMed  CAS  Google Scholar 

  • Pernow B, Waldenstrom J (1954) Paroxysmal flushing and other symptoms caused by 5 hydroxytrypt-amine and histamine in patients with malignant tumours. Lancet 11: 951

    Google Scholar 

  • Pernow B, Waldenstrom J (1957) Determination of 5-hydroxytryptamine, 5-hydroxy-indole acetic acid and histamine in thirty three cases of carcinoid tumors (argentaffinoma). Am J Med 23: 16–25

    PubMed  CAS  Google Scholar 

  • Plonk JW, Feldmann JM (1974) Carcinoid arthropathy. Arch Intern Med 134: 651–654

    PubMed  CAS  Google Scholar 

  • Portela-Gomes GM (1982) Enterochromaffin cells. A qualitative and quantitative study. University of Uppsala

    Google Scholar 

  • Rask-Madsen J and Bukhave K (1979) Prostaglandins and chronic diarrhoea: Clinical aspects. Scand J Gastroenterol [Suppl 53] 14: 73–78

    CAS  Google Scholar 

  • Reichardt W (1978) Angiographischer Befund bei Karzinoidmetastasen im Mesenterium. Fortschr Röntgenstr 129: 185–188

    CAS  Google Scholar 

  • Roberts WC, Sjoerdsma A (1964) The cardiac disease associated with the carcinoid syndrome (carcinoid heart disease). Am J Med 36: 5–34

    PubMed  CAS  Google Scholar 

  • Robertson JIS, Peart WS, Andrews TM (1962) The mechanism of facial flushes in the carcinoid syndrome. Q J Med 31: 103–123

    PubMed  CAS  Google Scholar 

  • Roggli VL, Judge DM, McGavran MH (1979) Duodenal glucagonoma: A case report. Hum Pathol 10: 350–353

    Google Scholar 

  • Rosenbaum FF, Santer DG, Claudon DB (1953) Essential teleangiectasia, pulmonic and tricuspid stenosis, and neoplastic liver disease. A possible new clinical syndrome. J Lab Clin Med 42: 941–942

    Google Scholar 

  • Said SI and Mutt V (1977) Relationship of spasmogenic and smooth muscle relaxant peptides from normal lung to other vasoactive peptides. Nature 265: 84–86

    PubMed  CAS  Google Scholar 

  • Sanders RJ (1973) Carcinoids of the gastrointestinal tract. Thomas, Springfield USA

    Google Scholar 

  • Sandler M, Snow PDJ (1958) An atypical carcinoid tumor secreting 5-hydroxytryptophan. Lancet 1: 137–140

    PubMed  CAS  Google Scholar 

  • Schauer A, Eder M (1959) Der Fibrosierungsvorgang beim Darmcarcinoid. Klin Wochenschr 37: 880–881

    PubMed  CAS  Google Scholar 

  • Schmidt JE (1905) Beiträge zur normalen und pathologischen Histologie einiger Zellarten der Schleimhaut des menschlichen Darmkanals. Arch Mikr Anat 66: 12–40

    Google Scholar 

  • Schön H, Ordnung W, Schmid E (1960) Zum Nachweis der 5-Hydroxyindolessigsäure im Harn. Klin Wochenschr 38: 405–406

    Google Scholar 

  • Schölte AJ (1931) Ein Fall von Angioma teleangiectaticum cutis mit chronischer Endocarditis und malignem Dünndarmcarcinoid. Beitr Pathol Anat 86: 440–443

    Google Scholar 

  • Schuhmacher A, Schulz H (1963) Licht- und elektronenmikroskopische Untersuchungen an einem metastasierenden Dünndarmcarcinoid mit Serotoninbestimmungen an Tumorzellfraktionen. Klin Wochenschr 41: 1188–1196

    Google Scholar 

  • Schweizer W, Gloor F, von Bertrap R, Dubach UC (1964) Carcinoid heart disease with left-sided lesions. Circulation 29: 253–257

    PubMed  CAS  Google Scholar 

  • Serratoni FT, Robboy SJ (1975) Ultrastructure of primary and metastatic ovarian carcinoids: Analysis of 11 cases. Cancer 36: 157–160

    PubMed  CAS  Google Scholar 

  • Sherman SP, Li C-Y, Carney JA (1979) Microproliferation of enterochromaffin cells and the origin of carcinoid tumors of the ileum. Arch Pathol Lab Med 103: 639–641

    PubMed  CAS  Google Scholar 

  • Sjoerdsma A, Weissbach H, Udenfriend S (1955) Simple test for diagnosis of metastatic carcinoid ( Argentaffinoma ). JAMA 159: 397

    Google Scholar 

  • Sjoerdsma A, Weissbach H, Terry LL, Udenfriend S (1957) Further observations on patients with malignant carcinoid. Am J Med 23: 5–15

    PubMed  CAS  Google Scholar 

  • Sjoerdsma A, Lovenberg W, Engelman K, Carpenter WT, Wyatt RJ, Gessa GL (1970) Serotonin now: Clinical implications of inhibiting its synthesis with para chlorophenylalanine. Ann Intern Med 73: 607–629

    Google Scholar 

  • Skrabanek P, Cannon D, Kirrane J, Powell D (1978) Substance P secretion by carcinoid tumours. Ir J Med Sci 147: 47–49

    PubMed  CAS  Google Scholar 

  • Soga J (1976) Neoplasms of the GEP endocrine cells: The present-day concept of carcinoids. In: Fujita T (ed) Endocrine gut and pancreas. Elsevier, Amsterdam, pp 387–394

    Google Scholar 

  • Soga J, Tazawa K (1971) Pathologic analysis of carcinoids. Cancer 28: 990–998

    PubMed  CAS  Google Scholar 

  • Solcia E, Capella C, Buffa R, Frigerio B (1976) Histochemical and ultrastructural studies on the argentaffin and argyrophil cells of the gut. In: Coupland RE, Fujita T (eds) Chromaffin, enterochromaffin and related cells. Elsevier Scientific Publishing Company, Amsterdam Oxford New York, pp 209–225

    Google Scholar 

  • Solcia E, Buffa R, Crivelli O, Yanaihara N, Polak JM (1981a) Immunohistochemistry of gastric releasing peptide (GRP) and 5-hydroxytryptamine (5 HT) in the gut neuroendocrine systeme. International Symposion on Brain-Gut Axis, Florenz, 1981 [Abstr], p 168

    Google Scholar 

  • Solcia E, Capella C, Buffa R, Usellini L, Fiocca R, Frigerio B, Tenti P, Sessa F (1981b) The diffuse endocine-paracrine system of the gut in health and disease: Ultrastructural features. Scand J Gastroenterol [Suppl 70] 14: 25–36

    Google Scholar 

  • Stahl SM, Levin B (1982) Serotonin depletion by fenfluramine in the carcinoid syndrome. N Engl J Med 306: 429

    PubMed  CAS  Google Scholar 

  • Steger C, Sarra A (1960) Zur Entstehung der beim metastasierenden Dünndarmkarzinoid beobachteten Klappen Veränderungen des rechten Herzens. Helv Chir Acta 27: 15–29

    Google Scholar 

  • Steger C, Sette B (1964) Über die pathogenetische Bedeutung des 5-Hydroxytryptamins in der Entstehung der Klappen Veränderungen des rechten Herzens bei Karzinoidträgern. Helv Chir Acta 31: 353–363

    PubMed  CAS  Google Scholar 

  • Sternberger LA (1974) Immunocytochemistry Englewood Cliffs. Prentice-Hall, New Jersey Swain CP, Tavill AS, Neale G (1976) Studies of tryptophan and albumin metabolism in a patient with carcinoid syndrome, pellagra, and hypoproteinemia. Gastroenterology 71: 484–489

    Google Scholar 

  • Thorson A, Biörck G, Björkman G, Waldenstrom J (1954) Malignant carcinoid of the small intestine with metastases to the liver, valvular disease of the right side of the heart (pulmonary stenosis and tricuspid regurgitation without septal defects), peripheral vasomotor symptoms, bronchoconstriction, and an unusual type of cyanosis. A clinical and pathologic syndrome. Am Heart J 47: 795–817

    Google Scholar 

  • Thulin L, Samnegard H, Tyden G, Long DH, Efendic S (1978) Efficacy of somatostatin in a patient with carcinoid syndrome. Lancet II: 43 Udenfriend S, Weissbach H, Clark CT (1955) The estimation of 5-hydroxytryptamin (serotonin) in biological tissues. J Biol Chem 215: 337–344

    Google Scholar 

  • Vassallo G, Capella C, Solcia E (1971) Grimelius silver stain for endocrine cell granules, as shown by electron microscopy. Stain Technol 46: 7–13

    PubMed  CAS  Google Scholar 

  • Verley JM (1965) Les tumeurs carcinoides bronchiques et digestives de l’homme. Z Krebsforsch 66: 503–516

    Google Scholar 

  • Waldenstrom J, Pernow B, Silver H (1956) Case of metastasizing carcinoma (argentaffinoma?) of unknown origin showing peculiar red flushing and increased amounts of histamine and 5-hydroxytryptamine in blood and urine. Acta Med Scand 156: 73–83

    PubMed  CAS  Google Scholar 

  • Weichert R, Reed R, Creech O (1967) Carcinoid-islet cell tumors of the duodenum. Ann Surg 5: 660–669

    Google Scholar 

  • Weidner FA, Ziter FMH (1981) Carcinoid tumors of the gastrointestinal tract. JAMA 245: 1153–1155

    PubMed  CAS  Google Scholar 

  • Wilander E, El-Salhy M (1981) Immuno-cyto-chemical staining of mid-gut carcinoid tumours with sequence-specific gastrin antisera. Acta Pathol Microbiol Scand Sect A 89: 247–250

    CAS  Google Scholar 

  • Wilander E, Portela-Gomes G, Grimelius L, Lundqvist G, Skoog V (1977 a) Enteroglucagon and substance P-like immunoreactivity in argentaffin and argyrophil rectal carcinoids. Virchows Arch B Cell Pathol 25: 117–124

    Google Scholar 

  • Wilander E, Portela-Gomes G, Grimelius L, Westermark P (1977) Argentaffin and Argyrophil reactions of human gastrointestinal carcinoids. Gastroenterology 73: 733–736

    PubMed  CAS  Google Scholar 

  • Wilander E, Grimelius L, Portela-Gomes G, Lundqvist G, Skoog V, Westermark P (1979) Substance P and enteroglucagon-like immunoreactivity in argentaffin and argyrophil midgut carcinoid tumours. Scand J Gastroenterol [Suppl 53] 14: 19–25

    Google Scholar 

  • Wilkin JK (1981) Flushing Reactions: Consequences and mechanisms. Ann Intern Med 95: 468–476

    PubMed  CAS  Google Scholar 

  • Williams ED, Sandler M (1963) The Classification of carcinoid tumours. Lancet 1: 238–239

    PubMed  CAS  Google Scholar 

  • Williams ED, Siebenmann RE, Sobin LH (1980) Histological typing of endocrine tumours. Internat histological classifications of tumours. No. 23, World Health Organization, Genf, pp 46–52

    Google Scholar 

  • Wood WJ, Archer R, Schaeffer JW, Stephens C, Griffen WO (1970) Coexistence of regional enteritis and carcinoid tumor. Gastroenterology 59: 265–269

    PubMed  CAS  Google Scholar 

  • Woodtli W, Gemsenjager E, Heitz Ph U, Gloor F, Rosch W, Bosseckert H (1982) Endokrine Tumoren ( APUDome) des Duodenums - Eine kooperative Studie. Schweiz Rundschau Med 71: 1045–1053

    Google Scholar 

  • Yang D, Garner R, Beetham WP (1978) Dermatomyositis, myocardial involvement, and carcinoid syndrome. JAMA 239: 1067–1068

    PubMed  CAS  Google Scholar 

  • Zakariai YM, Quan SHQ, Hajdu SI (1975) Carcinoid tumors of the gastrointestinal tract. Cancer 35: 588–591

    PubMed  CAS  Google Scholar 

  • Zarafonetis CJD, Lorber SH, Hanson SM (1958) Association of functioning carcinoid syndrome and scleroderma. Am J Med Sci 236: 1–14

    PubMed  CAS  Google Scholar 

  • Zeegen R, Rothwell-Jackson R, Sundler M (1969) Massive hepatic resection for the carcinoid syndrome. Gut 10: 617–622

    PubMed  CAS  Google Scholar 

  • Zuluaga U (1979) Karzinoid and Karzinoidsyndrom. Rita G Fischer, Frankfurt

    Google Scholar 

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Authors
  1. G. E. Feurle
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  2. V. Helmstädter
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  1. Medizinische Klinik II, Stadtkrankenhaus, Leimenstr. 20, D-6450, Hanau 1, Germany

    W. F. Caspary

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Feurle, G.E., Helmstädter, V. (1983). Endokrine Tumoren des Dünndarms. In: Bommer, W., et al. Dünndarm B. Handbuch der inneren Medizin, vol 3 / 3 / B. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68897-3_10

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