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Biophysics pp 372-394 | Cite as

Enzymes as Biological Catalysts

  • Robert Huber
  • William S. BennettJr.
  • Georg E. Schulz

Abstract

Proteins perform many different functions in the living organism:
  • enzymes are catalysts

  • hormones are messengers in regulatory processes, immune proteins recognize, bind and, after a multi-step process, eliminate foreign molecules and cells

  • regulatory proteins bind and modify the function of other macromolecules

  • contractile proteins perform mechanical work,

  • transport proteins move specific molecules across boundaries, e.g., through membranes,

  • structural proteins form tissue, shells, etc.

Keywords

Polypeptide Chain Peptide Bond Tobacco Mosaic Virus Globular Protein Folding Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Selected References

  1. Baldwin, R. L.: Intermediates in Protein Folding Mechanism and the Mechanism of Protein Folding. Ann. Rev. Biochem. 44, 453 (1975).CrossRefGoogle Scholar
  2. Bruice, T.C.: Views on Approximation. Orbital Steering, and Enzymatic and Model Reactions. Cold Spring Harb. Symp. Quant. Biol. 36, 21 (1972).Google Scholar
  3. Changeaux, J.-P.: The Control of Biochemical Reactions. Sci. Amer. (April) 1965.Google Scholar
  4. Davie, E. W., Fujikawa, K.: Basic Mechanism of Blood Coagulation. Ann. Rev. Biochem. 44, 799 (1975).CrossRefGoogle Scholar
  5. Davies, D.R., Padlan, E.A., Segal, D.M.: The Three-dimensional Structure of Immunoglobulins. Ann. Rev. Biochem. 44, 639 (1975).CrossRefGoogle Scholar
  6. Dickerson, R. E., Geis, I.: The Structure and Action of Proteins. New York-Evaston-London: Harper and Row 1969.Google Scholar
  7. Edelman, E.M.: The Structure and Function of Antibodies. Sci. American (August) 1970.Google Scholar
  8. Florkin, M., Stotz, E.H. (Eds.): Enzymes. General Considerations: in Comprehensive Biochemistry. Amsterdam: Elsevier 1964.Google Scholar
  9. Jencks, W. P.: Structure-Reactivity Correlations and General Acid-Base Catalysis in Enzymic Transacylation Reactions. Cold Spring Harbor Symp. Qant. Biol. 34, 1 (1972).Google Scholar
  10. Koshland, Jr., D.E., Carraway, K.W., Dafforn, G.A., Gass, J.D., Storm, D.R.: The Importance of Orientation Factors in Enzymatic Reactions. Cold Spring Harbor Symp. Quant. Biol. 36, 13 (1972).Google Scholar
  11. Koshland, Jr., DE., Neet, K.E.: The Catalytical Regulatory Properties of Enzymes. Ann. Rev. Biochem. 37, 359 (1968).CrossRefGoogle Scholar
  12. Müller-Eberhard, H.J.: Complement. Ann. Rev. Biochem. 44, 697 (1975).CrossRefGoogle Scholar
  13. Neurath, H.: Protein-Digesting Enzymes. Sci. American (December) 1964.Google Scholar
  14. Wetlaufer, D.B., Ristow, S.: Acquisition of Three-Dimensional Structure of Proteins. Ann. Rev. Biochem. 42, 135 (1973).CrossRefGoogle Scholar
  15. Wu, T. T., Fitch, W. M., Margoliash, E.: The Information Content of Protein Amino Acid Sequences. Ann. Rev. Biochem. 43, 539 (1974).CrossRefGoogle Scholar
  16. Anfinsen, C.B., Scheraga, H.A.: Experimental and theoretical aspects of protein folding. Adv. Protein Chem. 29, 205–300 (1975).CrossRefGoogle Scholar
  17. Butler, P.J.G., Klug, A.: The assembly of a virus. Sci. Am. November (1978).Google Scholar
  18. Harrison, S.C.: Structure of simple viruses: specificity and flexibility in protein assemblies. Trends Biochem. Sci. 3, 3–7 (1978).Google Scholar
  19. Levitt, M., Chothia, C.: Structural patterns in globular proteins. Nature (London) 261, 552–557 (1976).ADSCrossRefGoogle Scholar
  20. McLachlan, A.D.: Quantum chemistry and protein folding: The art of the possible. Int. J. Quant. Chem. 12, 371–385 (1977).Google Scholar
  21. Richardson, J.S.: ß-Sheet topology and the relatedness of proteins. Nature (London) 268, 495–500 (1977).ADSCrossRefGoogle Scholar
  22. Schulz, G.E., Schirmer, R.H.: Principles of Protein Structure. Berlin, Heidelberg, New York: Springer 1979.CrossRefGoogle Scholar
  23. Stubbs, G., Warren, S., Holmes, K.: Structure of RNA and RNA binding site in tobacco mosaic virus from 4 Ä map calculated from X-ray fibre diagrams. Nature (London) 267, 216–221 (1977).ADSCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Robert Huber
  • William S. BennettJr.
  • Georg E. Schulz

There are no affiliations available

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