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Wirkungsspektren von Antiarrhythmika und Betarezeptorenblockern

  • Chapter
Herzrhythmusstörungen

Part of the book series: Handbuch der inneren Medizin ((INNEREN 9,volume 9 / 1))

Zusammenfassung

Herzrhythmusstörungen bleiben eine Erkrankung von wesentlicher Bedeutung für die Gesundheit der Bevölkerung und ihre Therapie eine Herausforderung für den Arzt. Die Probleme in Diagnose und Therapie sind zahlreich, und groß war und ist deshalb der Wunsch nach einer rationalen Basis für die Therapie. In den letzten 20 Jahren ist die Zahl jener Arbeiten rapide angewachsen, welche sich mit der Entstehung von Herzrhythmusstörungen und mit der Wirkungsweise von Antiarrhythmika auseinandersetzen. Weiter konnten vor 20 Jahren fast 90% der heute möglichen Verordnungen nicht ausgeführt werden, weil das Angebot an Arzneimitteln sehr viel kleiner war. Beide raschen Entwicklungen können für die Therapie nur dann echte Vorteile bringen, wenn sie auch zur Verbreiterung der rationalen Basis der Therapie mit Antiarrhythmika beitragen. In der Therapie mit Antiarrhythmika haben deshalb neben der subjektiven Erleichterung des Patienten und der klinisch objektivierbaren Besserung des Befundes experimentelle Ergebnisse mit pharmakologischen, physiologischen und biophysikalischen Methoden das besondere Interesse des Klinikers gefunden. Molekulare und zelluläre Effekte werden bevorzugt herangezogen, um die biologische Wirkung bzw. die recht unterschiedlichen Wirkungsspektren der Antiarrhythmika zu beschreiben und klinische Ergebnisse theoretisch zu untermauern.

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Literatur

  • Åblad B, Carlsson E, Dahlöf C, Ek L (1975) Some aspects on the pharmacology of adrenergic β-receptor blockers. In: Berglund G, Hansson L, Werkö L (eds) Pathophysiology and management of arterial hypertension. Lindgen & Söner, Mölndal, Sweden, pp 152–166

    Google Scholar 

  • Abrams WB, Davies RO (1973) The antiarrhythmic mechanisms of betaadrenergic blocking agents. In: Dreifus LS, Likoff W (eds) Cardiac arrhythmias. Grune & Stratton, New York, p 517

    Google Scholar 

  • Ahlquist RP (1948) A study of adrenotropic receptors. Am J Physiol 153:586

    PubMed  CAS  Google Scholar 

  • Ariens EJ (1966) Receptor theory and structure-action relationship In: Harper NY, Simmonds AB (eds) Advances in drug research. Academic Press, London New York, p 235

    Google Scholar 

  • Arlock P, Gullber B, Olsson SOR (1978) Cardiac physiology of four neuroleptics: melperone, haloperidol, thioridazine and chlorpromazine. Naunyn Schmiedebergs Arch Pharmacol 304/1:27–36

    Article  Google Scholar 

  • Arnsdorf MF (1977) The effect of antiarrhythmic drugs on triggered sustained rhythmic activity in cardiac Purkinje fibers. J Pharmacol Exp Ther 201/3:689–700

    Google Scholar 

  • Arnsdorf MF, Bigger JT (1975) The effects of lidocaine on components of excitability in long mammalian cardiac Purkinje fibers. J Pharmacol Exp Ther 195:206

    PubMed  CAS  Google Scholar 

  • Arnsdorf MF, Bigger JT (1976) The effect of procain amide on components of excitability in long mammalian cardiac Purkinje fibers. Girc Res 38:115

    CAS  Google Scholar 

  • Arnsdorf MF, Hsieh YY (1978) Pharmacology of cardiovascular drugs: B. Antiarrhythmic agents. In: Hurst, Logue, Schlant, Wenger (eds) The heart, 4th edn. McGraw-Hill, New York

    Google Scholar 

  • Bachmann GW (1972) Beta-Sympathicolyse als therapeutisches Prinzip. Kurzmonographien Sandoz 7:17

    Google Scholar 

  • Barrett AM (1975) A survey of the pharmacological properties of adrenergic beta-receptor antagonists. In: Lydtin H, Meesmann W (Hrsg) Kardiale Sympathikolyse als therapeutisches Prinzip. Thieme, Stuttgart

    Google Scholar 

  • Barrett AM, Carter J (1970) Comparative chronotropic activity of β-adrenoceptive antagonists. Br J Pharmacol 40:373–381

    PubMed  CAS  Google Scholar 

  • Barrett AM, Cullum VA (1968) The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol 34:43

    PubMed  CAS  Google Scholar 

  • Barrett AM, Carter J, Fitzgerald JD, Hull R, LeCount D (1973) A new type of cardioselective adrenoceptive blocking drug. Br J Pharmacol 48:340

    Google Scholar 

  • Bassett AL, Hoffman B (1971) Antiarrhythmic drugs: Electrophysiologic actions. Ann Rev Pharmacol 11:143

    Article  PubMed  CAS  Google Scholar 

  • Bassett AL, Bigger J, Hoffman B (1970) “Protective” action of diphenylhydantoin on canine Purkinje fiber during hypoxia. J Pharmacol Exp Ther 173:336

    PubMed  CAS  Google Scholar 

  • Bayer BL, Forster W (1979) Actions of prostaglandin precursors and other unsaturated fatty acids on conduction time and refractory period in the cat heart in situ. Br J Pharmacol 66/2:191–195

    Google Scholar 

  • Beck OA, Hochrein H (1980) Medikamentöse Therapie von Herzrhythmusstörungen. In: Hochrein H (Hrsg) Herzrhythmusstörungen. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Belardinelli L, Belloni FL, Rubio R, Berne RM (1980) Atrioventricular conduction disturbances during hypoxia. Possible role of Adenosine in rabbit and guinea pig heart. Circ Res 47/5:684–691

    PubMed  CAS  Google Scholar 

  • Bellet S (1966) Electrolyte disorders in the genesis of cardiac arrhythmias. In: Dreifus LS, Likoff W (eds) Mechanism and therapy of cardiac arrhythmias. Grune & Stratton, New York

    Google Scholar 

  • Bender F (1968) Behandlung von Herzrhythmusstörungen mit Beta-Rezeptorenblockern. Wien Med Wochenschr 118:820

    PubMed  CAS  Google Scholar 

  • Bigger JT, Mandel W (1970) Effect of lidocaine on conduction in canine Purkinje fibers and at the ventricular muscle — Purkinje fiber junction. J Pharmacol Exp Ther 172:239

    PubMed  CAS  Google Scholar 

  • Bigger JT, Weld FM (1980) Shortcomings of the Lown grading system for observational or experimental studies in ischemic heart disease. Am Heart J 100/6/2:1081

    Google Scholar 

  • Bigger J, Bassett A, Hoffman B (1968) Electrophysiological effects of diphenylhydantoin on canine Purkinje fibers. Circ Res 22:221

    PubMed  CAS  Google Scholar 

  • Bjerregaard P (1980) Prevalence of variability of cardiac arrhythmias in healthy subjects. In: Chamberlain DA, Kulbertus H, Mogensen L, Schlepper M (eds) Cardiac arrhythmias in the active population. Hässle, Mölndal, Sweden

    Google Scholar 

  • Blinks JR (1967) Evaluation of the cardiac effects of several beta adrenergic blocking agents. Ann NY Acad Sci 139:673

    Article  PubMed  CAS  Google Scholar 

  • Brennan FJ (1980) Electrophysiologic effects of imipramine and doxepin in normal and depressed cardiac purkinje fibers. Am J Cardiol 46/4:599–606

    Article  Google Scholar 

  • Cahalan MD, Almers W (1979) Interactions between quarternary lidocaine, the sodium channel gates, and tetrodotoxin. Biophys J 27:39–56

    Article  PubMed  CAS  Google Scholar 

  • Challoner DR, Steinberg D (1966) The effects of free fatty acids on the oxygen consumption of the perfused rat heart. Am J Physiol 210:280–286

    PubMed  CAS  Google Scholar 

  • Charlier R, Deltour G, Baudine A, Chaillet F (1968) Pharmacology of amiodarone, an anti-anginal drug with a new biological profile. Arzneimittel-Forsch 18:1408

    CAS  Google Scholar 

  • Chen C, Gettes LS, Katzung BG (1975) Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium. Circ Res 37:19–29

    Google Scholar 

  • Choi SJ, Roberts J, Kelliher GJ (1972) The effect of propranolol and quinidine on 22Na- and 42K-exchange in the cat papillary muscle. Eur J Pharmacol 20:20

    Google Scholar 

  • Chung EK (1977) Electrolyte imbalance and cardiac arrhythmias. In: Principles of cardiac arrhythmias. Williams & Wilkins, Baltimore

    Google Scholar 

  • Cohen IS, Strichartz GR (1977) On the voltage-dependent actions of Tetrodotoxin. Biophys J 17:275–279

    Article  PubMed  CAS  Google Scholar 

  • Colatsky TJ, Tsien RW (1979) Sodium channels in rabbit cardiac purkinje fibers. Nature (London) 278/5701:265–268

    Article  Google Scholar 

  • Coltart DJ, Shand DG (1970) Plasma propranolol levels in the quantitativ assessment of β-adrenergic blockade in man. Br Med J 3:731

    Article  PubMed  CAS  Google Scholar 

  • Conolly ME, Kersting F, Dollery CT (1976) The clinical pharmacology of beta-adrenoceptor blocking drugs. Prog Cardiovasc Dis 19:203

    Article  PubMed  CAS  Google Scholar 

  • Coraboeuf E, Deroubaix E, Coulombe A (1980) Acidosis-induced abnormal repolarization and repetitive activity in isolated dog Purkinje fibers. J Physiol (Paris) 76/2:97–106

    Google Scholar 

  • Courtney KR (1980) Interval-dependent effects of small antiarrhythmic drugs on excitability of guinea-pig myocardium. J Mol Cell Cardiol 12:1273–1286

    Article  PubMed  CAS  Google Scholar 

  • Cruickshank JM (1980) The clinical importance cardioselectivity and lipophility in beta-blockers. Am Heart J 100:160–178

    Article  PubMed  CAS  Google Scholar 

  • Davis LD, Temte JV (1968) Effects of propranolol on the transmembrane potentials of ventricular muscle and Purkinje fibers of the dog. Circ Res 22:661

    PubMed  CAS  Google Scholar 

  • Dawes GS (1946) Synthetic substitute for quinidine. Br J Pharmacol 1:90

    CAS  Google Scholar 

  • Day JL (1975) The metabolic consequences of adrenergic blockade: a review. Metabolism 24:978–966

    Google Scholar 

  • Dreifus LS, Azevedo IM de, Watanabe Y (1974) Electrolyte and antiarrhythmic drug interaction. Am Heart J 88:95

    Article  PubMed  CAS  Google Scholar 

  • Dreifus LS, Azevedo IM de, Katz MR (1975) New antiarrhythmic drugs. In: Donoso E (ed) Current cardiovascular topics. Drugs in cardiology, part I. Thieme, Stuttgart, p 106

    Google Scholar 

  • Dunlop D, Shanks RG (1968) Selective blockade of adrenoceptive beta receptors in the heart. Br J Pharmacol Chemother 32:207–218

    Google Scholar 

  • Edvardsson N (1980) Electrophysiology classification of anti-arrhythmic drugs and beta-blockers. Curr Ther Res Clin Exp [Suppl] 28/1:113–118

    Google Scholar 

  • Ehrlich P (1913) Proc 17th Intern Congr Med

    Google Scholar 

  • Elkayam U, Frishman W (1980) Cardiovascular effects of phenothiazines. Am Heart J 100/3:397–401

    Article  Google Scholar 

  • Fisch C (1973) Relation of electrolyte disturbances to cardiac arrhythmias. Circulation 47:408

    PubMed  CAS  Google Scholar 

  • Fitzgerald JD (1972) Beta adrenergic blocking drugs. Present position and future developments. Acta Cardiol [Suppl] 15:199–216

    Google Scholar 

  • Fleckenstein A (1977) Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Ann Rev Pharmacol Toxicol 17:149

    Article  CAS  Google Scholar 

  • Fleckenstein A, Döring HJ, Kammermeier H (1968) Einfluß von β-Rezeptorenblockern und verwandten Substanzen auf Erregung, Kontraktion und Energiestoffwechsel der Myokardfaser. Klin Wochenschr 46:343

    Article  PubMed  CAS  Google Scholar 

  • Fozzard HA (1977) Excitability and passive electrical properties. Prog Cardiovasc Dis 14:343

    Article  Google Scholar 

  • Fozzard HA, Beeler GW (1975) The voltage clamp and cardiac electrophysiology. Circ Res 37:403

    PubMed  CAS  Google Scholar 

  • Freedberg AS, Papp JG, Vaughan-Williams EM (1970) The effect of altered thyroid state on atrial intracellular potentials. J Physiol (London) 207:357

    CAS  Google Scholar 

  • Furchgott RF (1972) The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In: Blaschko H, Muscholl E (eds) Catecholamines. Handbook of experimental pharmacology, vol 33. Springer, Berlin Heidelberg New York, pp 283–335

    Google Scholar 

  • Gettes LS (1979) On the classification of antiarrhythmic drugs. Med Conc Cardiovasc Dis 48/3:13–18

    CAS  Google Scholar 

  • Gettes LS, Surawicz B (1972) Principles of antiarrhythmic therapy in patients with acute myocardial infarction. In: Maeltzer LE, Dunning AJ (eds) Textbook of coronary care. Charles, Philadelphia Amsterdam, p 263

    Google Scholar 

  • Goldberg JJ (1972) Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev 24:1

    PubMed  CAS  Google Scholar 

  • Greeff K (1969) Pharmakologische und toxikologische Begleiterscheinungen der antifibrillatorischen Substanzen. Verh Dtsch Ges Kreislaufforsch 35:88

    PubMed  CAS  Google Scholar 

  • Grobecker H (1978) Experimentelle Untersuchungen zum Wirkungsmechanismus von Beta-Sympatholytika und ihre Bedeutung für die Behandlung des Blutdruckes. In: Lichtlen PR, Mäurer W, Schömig A, Dietz R (Hrsg) Betablockade. Thieme, Stuttgart

    Google Scholar 

  • Grobecker H, Delius W, Kübier W (eds) (1981) Catecholamines and the heart. Recent advances in experimental and clinical research. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Goupil N, Lenfant J (1976) The effects of amiodarone on the sinus node activity of the rabbit heart. Eur J Pharmacol 39:23

    Article  PubMed  CAS  Google Scholar 

  • Grant AO, Hondeghem LM, Katzung BG (1978) Effects of droperidol on depolarizationinduced automaticity. maximum upstroke velocity ((Equation)) and the kinetics of recovery of (Equation) in guinea pig ventricular myocardium. J Pharmacol Exp Ther 205/1:193–203

    Google Scholar 

  • Harms HH (1977) Cardioselective beta-adrenoceptor blocking argents: human and animal studies in vitro and in vivo. Thesis, Amsterdam, Europrint, Rijswijk, pp 115–127

    Google Scholar 

  • Heeg E (1978) Pharmakodynamische Aspekte rhythmisierender Substanzen. In: Antoni H, Bender F, Gerlach E, Schlepper M (Hrsg) Herzrhythmusstörungen. Schattauer, Stuttgart New York

    Google Scholar 

  • Heidrich H (1978) Myokardschäden und Herzrhythmusstörungen bei exogenen Intoxikationen. Med Welt 78/10:375–377

    Google Scholar 

  • Heissenbuttel PH, Bigger JT (1970) The effects of oral quinidine on intraventricular conduction in man: correlation of plasma quinidine with changes in QRS duration. Am Heart J 80:453

    Article  PubMed  CAS  Google Scholar 

  • Heistracher P (1971) Mechanism of action of antifibrillatory drugs. Naunyn Schmiedebergs Arch Exp Pathol Pharmacol 269:199–212

    CAS  Google Scholar 

  • Hille B (1977) Local anaesthetics: hydrophylic and hydrophobic pathways for drug receptor reactions. J Gen Physiol 69:497

    Article  PubMed  CAS  Google Scholar 

  • Hoffman BF, Bigger JT (1971) Antiarrhythmic drugs. In: Palma D (ed) Drill’s pharmacology in medicine, 4th edn. McGraw-Hill, New York, p 824

    Google Scholar 

  • Hoffman BF, Rosen MG, Wit AL (1975) Electrophysiology and pharmacology of cardiac arrhythmias. VII. Cardiac effects of quinidine and procainamide. Am Heart J 89:804–808,90:117–122

    Article  CAS  Google Scholar 

  • Hondeghem LM, Cotner CL (1978) Reproducible and uniform cardiac ischemia: effects of antiarrhythmic drugs. Am J Physiol 4/5:H574–H580

    Google Scholar 

  • Hondeghem LM, Katzung BG (1977) Time and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 472:373

    PubMed  CAS  Google Scholar 

  • Hondeghem LM, Katzung BG (1980) Test of a model of antiarrhythmic drug action. Circulation 61:1217–1226

    PubMed  CAS  Google Scholar 

  • Imura H, Kato Y, Ikeda M, Morimoto M, Yawate M (1971) Effect of adrenergic blocking or stimulating agents on plasma growth hormone, immuno reactive insulin, and blood free fatty acid levels in man. J Clin Invest 50:1069–1079

    Article  PubMed  CAS  Google Scholar 

  • Isenberg G (1977) Cardiac Purkinje fibers. (Ca2+)i controls steady state potassium conductance. Pflügers Arch Ges Physiol 37:71

    Google Scholar 

  • Jack JJB, Noble D, Tsien RW (1975) Electric current flow in excitable cells. Clarendon Press, Oxford

    Google Scholar 

  • Janse MJ (1979) Clinical relevance of experimentally obtained electrophysiologic data on antiarrhythmic drugs. Herz 4/4:323–329

    Google Scholar 

  • Jensen R, Katzung B (1970) Electrophysiological actions of diphenylhydantoin on rabbit atria. Circ Res 26:17

    PubMed  CAS  Google Scholar 

  • Johnson EA, MacKinnon MG (1957) Differential effect of quinidine and pyrilamine on the myocardial action potential at various rates of stimulation. J Pharmacol Exp Ther 120:460

    PubMed  CAS  Google Scholar 

  • Johnsson G, Regårdh CG (1976) Clinical pharmacokinetics of β-adrenoceptor blocking drugs. Clin Pharmacokinet 1:233–263

    Article  PubMed  CAS  Google Scholar 

  • Josephson ME, Caracta AR, Ricciutti MA, Lau SH, Damato AN (1974a) Electrophysiological properties of procaine amide in man. Am J Cardiol 33:596

    Article  PubMed  CAS  Google Scholar 

  • Josephson ME, Scides SF, Batsford WP, Weisfogel GM, Akhtar M, Caracta AR, Lau SH, Damato AM (1974b) The electrophysiological effect of intramuscular quinidine on the atrioventricular conducting system in man. Am Heart J 87:55

    Article  PubMed  CAS  Google Scholar 

  • Kabela E (1973) The effect of lidocaine on potassium efflux from various tissues of dog heart. J Pharmacol Exp Ther 184:611

    PubMed  CAS  Google Scholar 

  • Katholi CR, Urthaler F, Macy JJR, James TN (1977) A mathematical model of automaticity in the sinus node and AV junction based on weakly coupled relaxation oscillators. Comput Biomed Res 10/6:529–543

    Article  Google Scholar 

  • Katz AM (1977) Physiology of the heart. Raven Press, New York, pp 372–379

    Google Scholar 

  • Kaumann AJ, Aramendia P (1968) Prevention of ventricular fibrillation induced by coronary ligation. J Pharmacol Exp Ther 164:326–332

    PubMed  CAS  Google Scholar 

  • Kaumann AJ, Birnbaumer L, Wittmann R (1978) Heart β-adrenoceptors. In: O’Malley BW, Birnbaumer L (eds) Hormone receptors. Academic Press, New York

    Google Scholar 

  • Kersting F, Kasper W, Meinertz T (1979) 15 Jahre Therapie mit β-Rezeptorenblockern. Med Klin 74:1179–1188

    PubMed  CAS  Google Scholar 

  • Kesteloot H (1979) Cardiac toxicity of drugs. Excerpta Medica 470:639–640

    Google Scholar 

  • Koch-Weser J (1979) Drug therapy: disopyramide. N Engl J Med 300:957–962

    Article  PubMed  CAS  Google Scholar 

  • Köhler E (1972) β-Rezeptorenblocker: Pharmakologie und Therapie. Herz Kreisl 4:12–18

    Google Scholar 

  • Krause H, Tritthart H (1975) The role of myocardial membrane leakage channels in the production of fibrillation: studies with an analog computer model. In: Basic functions of cations in myocardial activity. Recent advances in studies on cardiac structure and metabolism, vol 5. University Park, Baltimore, p 295

    Google Scholar 

  • Krinsky VI (1978) Mathematical models of cardiac arrhythmias (spiral waves). Pharmacol Ther Part B 3/4:539–555

    CAS  Google Scholar 

  • Kurien VA, Oliver MF (1970) A metabolic cause for arrhythmias during acute myocardial infarction. Lancet 1:813

    Article  PubMed  CAS  Google Scholar 

  • Kurien VA, Yates PA, Oliver MF (1971) The role of free fatty acids in production of ventricular arrhythmias after acute coronary artery occlusion. Eur J Clin Invest 1:225

    PubMed  CAS  Google Scholar 

  • Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214:577–598

    Article  Google Scholar 

  • Langer GA (1978) The structure and function of the myocardial cell surface. Am J Physiol 235:H 461

    Google Scholar 

  • Lee KS, Hume JR, Giles W, Brown AM (1981) Sodium current depression by lidocain and quinidine in isolated ventricular cells. Nature 291:325–327

    Article  PubMed  CAS  Google Scholar 

  • Lown B, Graboys TB (1977) Management of patients with malignant ventricular arrhythmias. Am J Cardiol 39:910

    Article  PubMed  CAS  Google Scholar 

  • Lown B, Wolf M (1971) Approaches to sudden death from coronary heart disease. Circulation 44:130

    PubMed  CAS  Google Scholar 

  • Lown B, Calvert AF, Armington R, Ryan M (1975) Monitoring for serious arrhythmias and high risk of sudden death. Circulation 52:111–189

    Google Scholar 

  • Lucchesi BR (1965) The effects of pronethalol and its dextroisomer upon experimental cardiac arrhythmias. Pharmacol Exp Ther 148:94–99

    CAS  Google Scholar 

  • Lüderitz (1977) Die Behandlung von Herzrhythmusstörungen mit Betarezeptoren-blockern. Herz Kreisl 9, 10:541–548

    Google Scholar 

  • Marrannes R, Hemptinne A de, Leusen I (1979) Influence of lactate and other organic ions on conduction velocity in mammalian heart fibres depressed by “metabolic” acidosis. J Mol Cell Cardiol 11/4:359–374

    Article  Google Scholar 

  • Mirro MJ, Watanabe AM, Bailey JC (1980) Electrophysiological effects of disopyramide and quinidine on guinea pig atria and canine cardiac Purkinje fibers. Dependence on underlying cholinergic tone. Circ Res 46/5:660–668

    Google Scholar 

  • Mjøs OD (1971) Effect of free fatty acids on myocardial function and oxygen consumption in intact dogs. J Clin Invest 50:1386–1389

    Article  PubMed  Google Scholar 

  • Morales-Aguilera A, Vaughan-Williams EM (1965) The effects on cardiac muscle of beta-receptor antagonists in relation to their activity as local anaesthetics. Br J Pharmacol 24:332

    CAS  Google Scholar 

  • Moran NC, Perkins ME (1958) Adrenergic blockade of the mammalia heart by a dichloro-analogue of isoproterenol. J Pharmacol Exp Ther 124:223

    PubMed  CAS  Google Scholar 

  • Muscholl E, Rahn KH (1968) Adrenerge alpha- und beta-Rezeptoren und ihre spezifischen Hemmstoffe. Klin Wochenschr 46:113

    Article  PubMed  CAS  Google Scholar 

  • Nawrath H (1981) Action potential, membrane currents and force of contraction in mammalian heart muscle fibres treated with quinidine. J Pharmacol Exp Ther 216/1:176–182

    Google Scholar 

  • Nawrath H, Eckel L (1979) Electrophysiological study of human ventricular heart muscle treated with quinidine: interaction with isoprenalin. J Cardiovasc Pharmacol 1/4:415–425

    Article  Google Scholar 

  • Nickerson M (1973) Adrenergic receptors. Circ Res 32/33:53–60

    Google Scholar 

  • Noseda G (1973) Betablocker und Herzrhythmusstörungen. Schweiz Rundschau Med 32:983

    Google Scholar 

  • Opie LH (1980) Drugs and the heart: I. Betablocking agents. Lancet 1:693–698

    PubMed  CAS  Google Scholar 

  • Pamintuan JC, Dreifus LS, Watanabe Y (1970) Comparative mechanism of antiarrhythmic agents. Am J Cardiol 26:512–519

    Article  PubMed  CAS  Google Scholar 

  • Powell CE, Slater JH (1958) Blocking of inhibitory adrenergic receptors by a dichloroanalogue of isoproterenol. J Pharmacol Exp Ther 122:480

    PubMed  CAS  Google Scholar 

  • Prichard BNC (1976) The use of beta adrenergic blocking drugs in cardiovascular disease. Scott Med J 21:182–187

    PubMed  CAS  Google Scholar 

  • Prichard BNC (1978) Beta adrenergic blocking drugs and the treatment of high blood pressure. In: Rahn KH, Schrey A (Hrsg) Betablocker. Urban & Schwarzenberg, München Wien Baltimore

    Google Scholar 

  • Raptis S, Rosenthal J, Welzel D, Moulopoulos S (1981) Effects of cardio selective and non-selective beta-blockade on adrenaline-induced metabolic and cardiovascular responses in man. Eur J Clin Pharmacol 20:17–22

    Article  PubMed  CAS  Google Scholar 

  • Ravens KG, Jipp P (1972) Konzentrationsänderungen der freien Fettsäuren in der Frühphase nach einem Myokardinfarkt. Verh Dtsch Ges Inn Med 78:1033

    PubMed  CAS  Google Scholar 

  • Rosen MR, Hoffman BF, Wit AL (1975) Electrophysiology and pharmacology of cardiac arrhythmias: V. Cardiac antiarrhythmic effects of lidocaine. Am Heart J 89:526

    Article  PubMed  CAS  Google Scholar 

  • Rosenbaum MB, Chiale PA, Halpern MS (1976) Clinical efficacy of amidarone as an antiarrhythmic agent. Am J Cardiol 38:934

    Article  PubMed  CAS  Google Scholar 

  • Saameli K (1972) Die pharmakologische Charakterisierung β-symphatikolytischer Substanzen. In: Dengler HJ (Hrsg) Die therapeutische Anwendung β-sympathikoly tischer Stoffe. Schattauer, Stuttgart New York

    Google Scholar 

  • Sasyniuk BI, Ogilvie RI (1975) Antiarrhythmic drugs: Electrophysiological and pharmacokinetic considerations. Ann Rev Pharmacol 15:131

    Article  PubMed  CAS  Google Scholar 

  • Scherlag BJ (1980) The contribution of new intracardiac techniques to the understanding of human electrophysiology. In: Befeler B (ed) Selected topics in cardiac arrhythmias. Futura, Mount Kisco, New York, pp 9–23

    Google Scholar 

  • Schmitz W (1980) Klassifizierung neuer Antiarrhythmika nach elektrophysiologischen Gesichtspunkten. Klin Wochenschr 58:907–918

    Article  PubMed  CAS  Google Scholar 

  • Schoenberg M, Dominguez G, Fozzard HA (1975) Effect of diameter on membrane capacity and conductance of sheep cardiac Purkinje fibers. J Gen Physiol 65:441

    Article  PubMed  CAS  Google Scholar 

  • Schrader J, Baumann G, Gerlach E (1978) Katecholamin-antagonistische Wirkungen von Adenosin am Herzen. In: Antoni H, Bender F, Gerlach E, Schlepper M (Hrsg) Herzrhythmusstörungen. Schattauer, Stuttgart New York, S 161–170

    Google Scholar 

  • Schwarz JR, Ulbricht W, Wagner HH (1973) The rate of action of tetrodotoxin on myelinated nerve fibers of Xenopus laevis and Rana esculenta. J Physiol 233:167–194

    PubMed  CAS  Google Scholar 

  • Sekiya A, Vaughan-Williams EM (1963) A comparison of the antifibrillatory action and effects on intracellular cardiac potentials of pronethalol, disopyramide and quinidine. Br J Pharmacol 21:473

    CAS  Google Scholar 

  • Senges J, Brachmann J, Pelzer D (1979) Effects of some components of ischemia on electrical activity and reentry in the canine ventricular conducting system. Circ Res 44/6:864–872

    Google Scholar 

  • Shand DG (1977) Pharmacokinetic properties of the beta-adrenoceptor blocking drugs. Cardiovascular drugs, vol 2: Betaadrenoceptor blocking drugs. Adis, Australasia PTY, pp 41–54

    Google Scholar 

  • Simonsen S, Jekshus JK (1978) The effect of free fatty acids on myocardial oxygen consumption during pacing and catecholamine infusion in man. Circulation 58/3:484–491

    Google Scholar 

  • Singh BN (1977) Side effects of antiarrhythmic drugs. Pharmacol Ther C 2:151

    CAS  Google Scholar 

  • Singh BN (1978) Rational basis of antiarrhythmic therapy: clinical pharmacology of commonly used antiarrhythmic drugs. Angiology 29:206–242

    Article  PubMed  CAS  Google Scholar 

  • Singh BN, Hauswirth O (1974) Comparative mechanisms of action of antiarrhythmic drugs. Am Heart J 87:367–382

    Article  PubMed  CAS  Google Scholar 

  • Singh BN, Jewitt DE (1974) Beta-adrenergic receptor blocking drugs in cardiac arrhythmias. Drugs 7:426

    Article  PubMed  CAS  Google Scholar 

  • Singh BN, Vaughan-Williams EM (1970) The effect of amiodarone, a new antianginal drug, on intracellular potentials and other properties of isolated cardiac muscle. Br J Pharmacol 39:675–687

    PubMed  CAS  Google Scholar 

  • Smith HJ (1982) The need to redefine membrane stabilizing activity of beta-adrenergic receptor antagonists. J Mol Cell Cardiol 14:495–500

    Article  PubMed  CAS  Google Scholar 

  • Somberg JC, Bounous H, Levitt B (1979) The antiarrhythmic effects of quinidine and propranolol in the ouabain-intoxicated spinally transsected cat. Eur J Pharmacol 54,1–2:161–166

    Google Scholar 

  • Steinbeck G, Manz M, Lüderitz B (1981) Kontrolle der medikamentösen Arrhythmiebehandlung (Mexiletin, Amiodarone) durch programmierte Ventrikelstimulation bei Patienten mit chronisch rezidivierenden Kammertachykardien. In: Lüderitz B (Hrsg) Ventrikuläre Herzrhythmusstörungen. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Stevens Ch F (1977) Study of membrane permeability changes by fluctuation analysis. Nature 270:391

    Article  PubMed  CAS  Google Scholar 

  • Stimmel B (1975) The effects of mood-altering drugs on the heart. In: Donoso E (ed) Current cardiovascular topics, vol I, Drugs in cardiology. Thieme, Stuttgart, pp 203–234

    Google Scholar 

  • Strauss HC, Bigger JT, Bassett AL, Hoffman BF (1968) Action of diphenylhydantoin on the electrical properties of isolated rabbit and canine atria. Circ Res 23:463

    PubMed  CAS  Google Scholar 

  • Ten Eick RE, Singer DH (1979) Electrophysiological properties of diseased human atrium. Low diastolic potential and altered cellular response to potassium. Circ Res 44/4:545–557

    Google Scholar 

  • Touboul P (1980) Recent concepts in electrophysiology of antiarrhythmic drugs in man. In: Befeler B (ed) Selected topics in cardiac arrhythmias. Futura, Mount Kisco, New York

    Google Scholar 

  • Trautwein W (1973) Membrane currents in cardiac muscle fibers. Physiol Rev 53:793

    Google Scholar 

  • Tritthart H (1977) Die medikamentöse Therapie der Erregungsbildungs- und -leitungsstörungen: Die elektrophysiologischen Grundlagen. In: Reindell H, Roskamm H (Hrsg) Herzkrankheiten. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Tritthart H (1979) Über das Wirkungsspektrum der Antiarrhythmika. In: Antoni H, Bender F, Gerlach E, Schlepper M (Hrsg) Herzrhythmusstörungen. Schattauer, Stuttgart New York, S 313–325

    Google Scholar 

  • Tritthart H (1981) Wirkungsspektren von Antiarrhythmika. In: Lüderitz B (Hrsg) Ventrikuläre Herzrhythmusstörungen. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Tritthart H, Fleckenstein B, Fleckenstein A (1971) Some fundamental actions of antiarrhythmic drugs on the excitability and the contractility of single myocardial fibers. Naunyn Schmiedebergs Arch Exp Pathol Pharmacol 269:212

    CAS  Google Scholar 

  • Vaughan-Williams EM (1970) Classification of antiarrhythmic drugs. In: Sandøe E, Flenstedt-Jensen E, Olesen KH (eds) Symposium on cardiac arrhythmias. Södertälje, Astra, Sweden, pp 449–471

    Google Scholar 

  • Vaughan-Williams EM (1975) Classification of antidysrhythmic drugs. Pharmacol Ther B 1:115

    PubMed  CAS  Google Scholar 

  • Wagner J (1970) Beitrag zur Pharmakologie der Beta-Adrenolytika. Dtsch Med Wochenschr 48:2442

    Article  Google Scholar 

  • Wale JL, Bilski A (1978) Intrinsic sympathomimetic activity and myocardial contractility — experimental studies. In: Mäurer W, Schönig A, Dietz R, Lichtlen PR (Hrsg) Beta-Blockade. Thieme, Stuttgart

    Google Scholar 

  • Walton M, Fozzard HA (1979) The relation of Vmax to FNa, GNa and in a model of the cardiac Purkinje fiber. Biophys J 25:407–420

    Article  PubMed  CAS  Google Scholar 

  • Wang CM, James CA (1979) An analysis of the direct effect of chlorodiazepoxide on mammalian cardiac tissues and crayfish and squid giant axons: possible basis of antiarrhythmic activity. Life Sci 24/15:1357–1365

    Article  PubMed  CAS  Google Scholar 

  • Wang CM, Parker CH (1980) Reassessment of the electrophysiological effects of the antiarrhythmic agent quinidine in canine Purkinje fibers. Life Sci 27/8:663–670

    Article  Google Scholar 

  • Wasserman MA, Levy B (1974) Selective beta adrenergic receptor antagonism in the anesthetized dog. J Pharmacol Exp Ther 188:357–367

    PubMed  CAS  Google Scholar 

  • Weidmann SJ (1955) Effects of calcium ions and local anaesthetics on electrical properties of Purkinje fibers. J Physiol 129:568–582

    PubMed  CAS  Google Scholar 

  • Weidner A, Engels I (1978) Nebenwirkungen rhythmisierender Pharmaka. In: Antoni H, Bender F, Gerlach E, Schlepper M (Hrsg) Herzrhythmusstörungen. Schattauer, Stuttgart New York, S 387–402

    Google Scholar 

  • Weld FM, Bigger JT (1976) The effect of lidocaine on diastolic transmembrane currents determining pacemaker depolarizations in cardiac Purkinje fibers. Circ Res 38:203

    PubMed  CAS  Google Scholar 

  • Weld FM, Bigger JT (1980) Electrophysiological effects of imipramine on bovine cardiac Purkinje and ventricular muscle fibers. Circ Res 46/2:167–175

    PubMed  CAS  Google Scholar 

  • Wellens HJJ (1978) The electrophysiologic properties of the accessory pathway of the Wolff-Parkinson-White syndrome. In: Wellens HJJ, Lie M, Janse MJ (eds) The conduction system of the heart. Martinus Nijhoff, The Hague, p 567

    Google Scholar 

  • Winkle RA (1978) Antiarrhythmic drug effect mimicked by spontaneous variability of ventricular ectopy. Circulation 57/6:1116–1121

    Google Scholar 

  • Wit AL, Hoffman BF, Rosen MR (1975a) Electrophysiology and pharmacology of cardiac arrhythmias: IX. Cardiac electrophysiologic effects of beta adrenergic receptor stimulation and blockade. Am Heart J A 90:521

    Article  CAS  Google Scholar 

  • Wit AL, Hoffman BF, Rosen MR (1975b) Electrophysiology and pharmacology of cardiac arrhythmias: IX. Cardiac electrophysiologic effects of beta adrenergic receptor stimulation and blockade. Am Heart J B 90:665

    Article  CAS  Google Scholar 

  • Wit AL, Hoffman BF, Rosen MR (1975c) Electrophysiology and pharmacology of cardiac arrhythmias: IX. Cardiac electrophysiologic effects of beta adrenergic receptor stimulation and blockade. Am Heart J C 90:795

    Article  CAS  Google Scholar 

  • Wolfson S, Cohen LS (1975) Beta-adrenergic blocking agents: a clinical appraisal. In: Donoso E (ed) Current cardiovascular topics, vol. I, Drugs in cardiology, part 1. Thieme, Stuttgart, p 165

    Google Scholar 

  • Yasaka WJ, Eichbaum FW, Oga S (1979) Antiarrhythmic effects of solvents. II. Effects of propylene glycol and benzyl alcohol on the effective refractory period of isolated rabbit atria. Cardiovasc Res 13/12:711–716

    Article  Google Scholar 

  • Zeldis SM, Levine BJ, Michelson EL, Morgenroth J (1980) Cardiovascular complaints. Correlation with cardiac arrhythmias on 24-hour electrocardiographic monitoring. Chest 78/3:456–462

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. A. Tritthart
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Editors and Affiliations

  1. Medizinische Klinik B der Universität, Moorenstr. 5, D-4000, Düsseldorf, Deutschland

    G. Breithardt

  2. Medizinische Klinik und Poliklinik der Universität, Domagkstr. 3, D-4400, Münster, Deutschland

    Betty Brisse

  3. Pharmakologisches Institut der Universität, Obere Zahlbacher Str. 67, D-6500, Mainz, Deutschland

    E. Jähnchen , H. Nawrath  & D. Trenk ,  & 

  4. Medizinische Klinik der Universität, Langenbeckstr. 1, D-6500, Mainz, Deutschland

    W. Kasper , P. Matthiesen II  & T. Meinertz II ,  & 

  5. Institut für Pathologie, Evangelisches Krankenhaus Bethesda, Heerstr. 219, D-4100, Duisburg 1, Deutschland

    H.-J. Knieriem  & D. Mecking  & 

  6. Medizinische Klinik und Poliklinik, Universitätsklinikum Steglitz, Hindenburgdamm 30, D-1000, Berlin 45, Deutschland

    E.-R. von Leitner

  7. Innere Medizin — Kardiologie, Medizinische Universitätsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn, Deutschland

    B. Lüderitz

  8. Klinikum Großhadern, Medizinische Klinik I, Ludwig-Maximilians-Universität München, Marchioninistr. 15, D-8000, München 70, Deutschland

    C. Naumann d’Alnoncourt  & G. Steinbeck  & 

  9. Kerckhoff-Klinik, Benekestr. 4-6, D-6350, Bad Nauheim, Deutschland

    H. Neuss , M. Schlepper  & J. Thormann ,  & 

  10. Chirurgische Klinik B der Universität, Moorenstr. 5, D-4000, Düsseldorf, Deutschland

    J. Ostermeyer

  11. Medizinische Klinik, Abteilung Innere Medizin III, Otfried-Müller-Straße, D-7400, Tübingen 1, Deutschland

    L. Seipel

  12. Medizinische Klinik Innenstadt der Universität, Ziemssenstr. 1, D-8000, München 2, Deutschland

    K. Theisen

  13. Institut für Medizinische Physik and Biophysik der Universität, Harrachgasse 21, A-8010, Graz, Österreich

    H. A. Tritthart

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Tritthart, H.A. (1983). Wirkungsspektren von Antiarrhythmika und Betarezeptorenblockern. In: Breithardt, G., et al. Herzrhythmusstörungen. Handbuch der inneren Medizin, vol 9 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68872-0_4

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