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The Immunogenicity of Glucagon

  • Chapter
Glucagon I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 1))

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Abstract

The role which glucagon plays in the regulation of carbohydrate and fat metabolism is still not fully understood. Apart from early childhood, where glucagon seems to play a vital role in preventing hypoglycemia, it remains an enigma to what extent glucagon participates in maintaining normoglycemia in health and disease. Thus, in insulin-treated diabetics, insulin-induced hypoglycemia has been described as being defective, absent, or near normal. The role which glucagon may play in the development and maintenance of hyperglycemia in diabetes likewise remains a controversy, as some investigations report hyperglucagonemia while others find normal glucagon levels. A number of these differences may be apparent and caused by the use of glucagon antibodies with poorly defined specificity. Such antibodies when used in glucagon radioimmunoassays may yield different basal, as well as stimulated, levels of glucagon-like immunoreactivity (GLI).

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Authors
  1. L. G. Heding
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Editors and Affiliations

  1. University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Mèdecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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© 1983 Springer-Verlag Berlin Heidelberg

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Heding, L.G. (1983). The Immunogenicity of Glucagon. In: Lefèbvre, P.J. (eds) Glucagon I. Handbook of Experimental Pharmacology, vol 66 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68866-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-68866-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68868-3

  • Online ISBN: 978-3-642-68866-9

  • eBook Packages: Springer Book Archive

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