Skip to main content
SpringerLink
Log in

Glucagon and Liver Regeneration

  • Chapter
Book cover Glucagon I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 1))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andreis PG, Armato V (1981) Effects of epidermal growth factor/urogastrone and associated pancreatic hormones on mitotic cycle phases and proliferation kinetics of neonatal rat hepatocytes in primary culture. Endocrinology 108: 1954–1964

    PubMed  CAS  Google Scholar 

  • Avioli LV, Birge SJ, Scott S, Shieber W (1969) Role of the thyroid gland during glucagon-induced hypocalcemia in the dog. Am J Physiol 216: 939–945

    PubMed  CAS  Google Scholar 

  • Barrazzone P, Gorden P, Carpentier JL, Orci L, Freychet P, Canivet B (1980) Binding, internalization and lysozomal association of 125I-glucagon in isolated rat hepatocytes. J Clin Invest 66: 1081–1093

    Google Scholar 

  • Becker FF (1973) Humoral aspects of liver regeneration. In: LoBue J, Gordon AS (eds) Humoral control of growth and differentiation, vol I. Academic, New York London, pp 249–256

    Google Scholar 

  • Berg T, Iversen JG (1976) K+ transport in isolated rat liver cells stimulated by glucagon and insulin in vitro. Acta Physiol Scand 97: 202–208

    PubMed  CAS  Google Scholar 

  • Bex FJ, Corbin A, Sarantakis D, Lien E (1981) Absence of luteinizing hormone-releasing and anti-fertility properties in a glucagon-selective somatostatin analogue. Nature 291: 672–673

    PubMed  CAS  Google Scholar 

  • Bissell DM, Hammaker LE, Meyer VA (1973) Parenchymal cells from adult rat liver in non-proliferating monolayer culture. I. Functional studies. J Cell Biol 59: 722–734

    PubMed  CAS  Google Scholar 

  • Blasquez E, Rubalcava B, Montesano R, Orci L, Unger RH (1976) Development of insulin and glucagon binding and the adenylate cyclase response in liver membranes of the prenatal, postnatal, and adult rat: evidence of glucagon “resistance”. Endocrinology 98: 1014–1023

    Google Scholar 

  • Blumgart LH (1978) Liver atrophy, hypertrophy and regenerative hyperplasia in the rat: the relevance of blood flow. CIBA Found Symp 55: 181–215

    Google Scholar 

  • Bornstein P, Traub W (1980) Structurally distinct collagen types. Annu Rev Biochem 49: 957–1003

    PubMed  CAS  Google Scholar 

  • Boynton AL, Whitfield JF (1979) The cyclic AMP-dependent initiation of DNA synthesis by T51B rat liver epithelioid cells. J Cell Physiol 101: 139–148

    PubMed  CAS  Google Scholar 

  • Boynton AL, Whitfield JF (1980) Possible involvement of arachidonic acid in the initiation of DNA synthesis by rat liver cells. Exp Cell Res 129: 474–478

    PubMed  CAS  Google Scholar 

  • Broadus AE, Kaminsky NI, Northcutt RC, Hardman JG, Sutherland EW, Liddle GW (1970) Effects of glucagon on adenosine 3′,5′-monophosphate and guanosine 3′,5′- monophosphate in human plasma and urine. J Clin Invest 49: 2237–2245

    PubMed  CAS  Google Scholar 

  • Brooks RF, Bennett DC, Smith J A (1980) Mammalian cell cycles need two random transitions. Cell 19: 493–504

    PubMed  CAS  Google Scholar 

  • Bucher NLR, Malt RA (1971) Regeneration of liver and kidney. N Engl J Med, Med Progr Ser. Little, Brown, Boston, pp 1–176

    Google Scholar 

  • Bucher NLR, Swaffield MN (1975) Regulation of hepatic regeneration by synergistic action of insulin and glucagon. Proc Natl Acad Sci USA 72: 1157–1160

    PubMed  CAS  Google Scholar 

  • Bucher NLR, Weir GC (1976) Insulin, glucagon, liver regeneration and DNA synthesis, Metabolism 25: 1423–1425

    PubMed  CAS  Google Scholar 

  • Bucher NLR, Patel U, Cohen S (1978) Hormonal factors concerned with liver regeneration. CIBA Found Symp 55: 95–107

    CAS  Google Scholar 

  • Burridge K, Feramisco JR (1980) Microinjection and localization of a 130 K protein in living fibroblasts: a relationship to actin and fibronectin. Cell 19: 587–595

    PubMed  CAS  Google Scholar 

  • Cahn F, Lubin M (1978) Inhibition of elongation steps of protein synthesis at reduced potassium concentrations in reticulocytes and reticulocyte lysate. J Biol Chem 253: 7798–7803

    PubMed  CAS  Google Scholar 

  • Carlsson R, Engvall E, Freeman A, Ruoslahti E (1981) Laminin and fibronectin in cell adhesion: enhanced adhesion of cells from regenerating liver to laminin. Proc Natl Acad Sci USA 78: 2403–2406

    PubMed  CAS  Google Scholar 

  • Carpenter G, Cohen S (1979) Epidermal growth factor. Annu Rev Biochem 48: 193–216

    PubMed  CAS  Google Scholar 

  • Caruana J A, Gage A A (1980) Increased uptake of insulin and glucagon by the liver as a signal for liver regeneration. Surg Gynecol Obstet 150: 390–394

    PubMed  CAS  Google Scholar 

  • Castellano TJ, Schiffman RL, Jacob MC (1978) Suppression of liver cell proliferation by glucocorticoid hormones: a comparison of normally growing and regenerating tissue in the immature rat. Endocrinology 102: 1107–1112

    PubMed  CAS  Google Scholar 

  • Chisari FV (1977) Immunoregulatory properties of human plasma in very low density lipoproteins. J Immunol 119: 2129–2136

    PubMed  CAS  Google Scholar 

  • Chou JY, Schlegel-Hauter SE (1981) Study of liver differentiation in vitro. J Cell Biol 89: 216–222

    PubMed  CAS  Google Scholar 

  • Christoffersen T, Berg T (1974) Glucagon control of cyclic AMP accumulation in isolated intact rat liver parenchymal cells in vitro. Biochim Biophys Acta 338: 408–417

    CAS  Google Scholar 

  • Claret B, Claret M, Mazet JL (1973) Ionic transport and membrane potential of rat liver cells in normal and low chloride solutions. J Physiol (Lond) 230: 87–101

    CAS  Google Scholar 

  • Craven PA, De Robertis FR (1977) Hyperglucagonemia and altered responsiveness of hepatic adenylate cyclase-adenosine 3′,5′-monophosphate system to hormonal stimulation during chronic ingestion of DL-ethionine. Biochim Biophys Acta 497: 415–427

    PubMed  CAS  Google Scholar 

  • Crissman H (1975) Cell preparation and staining for flow systems. In: Richmond CR et al. (eds) Mammalian cells: probes and problems. First Los Alamos Sci Symp, Technical Information Center, OPA. US Energy Research and Development Administration, Washington, DC, pp 94–106

    Google Scholar 

  • Delbruck M, Bailey WT (1946) Induced mutations in bacterial viruses. Cold Spring Harbor Symp Quant Biol 11: 33–37

    Google Scholar 

  • De Robertis EDP, Nowinski WW, Saez FA (eds) (1973) General cytology. Saunders, Philadelphia London

    Google Scholar 

  • Dillman WH, Oppenheimer JH (1979) Glucagon influences the expression of thyroid hormone action: discrepancy between nuclear triodothyronine receptor number and enzyme responses. Endocrinology 105: 74–79

    Google Scholar 

  • Dillman WH, Bonner RA, Oppenheimer JH (1978) Glucagon administration decreases hepatic nuclear triodothyronine binding capacity. Endocrinology 102: 1633–1636

    Google Scholar 

  • Duckworth WC (1978) Insulin and glucagon binding and degradation by kidney cell membranes. Endocrinology 102: 1766–1774

    PubMed  CAS  Google Scholar 

  • Fabrikant J (1968) The kinetics of cellular proliferation in regenerating liver. J Cell Biol 36: 551–565

    PubMed  CAS  Google Scholar 

  • Fisher B, Szuch P, Fisher ER (1971) Evaluation of a humoral factor in liver regeneration utilizing liver transplants. Cancer Res 31: 322–331

    PubMed  CAS  Google Scholar 

  • Fisher B, Gebhardt MC, Saffer EA, Fisher ER (1979) Effect of Corynebacterium parvum in liver proliferation and regeneration. Cancer Res 39: 1361–1368

    PubMed  CAS  Google Scholar 

  • Freychet P, LeCam A (1978) Amino acid transport in isolated hepatocytes: effect of glucagon. Ciba Found Symp 55: 247–260

    CAS  Google Scholar 

  • Geelen MJH, Harris RA, Beynen AC, McCune SA (1980) Short-term hormonal control of hepatic lipogenesis. Diabetes 29: 1006–1022

    PubMed  CAS  Google Scholar 

  • Glitzer MS, Steelman SL (1966) N-amidino-3,5-diamino-6′-chloropyrazinecarboxamide: an active diuretic in the carboxamide series. Nature 212: 191–193

    PubMed  CAS  Google Scholar 

  • Goldman AL (1978) Influence of somatostatin on hepatic regeneration in the adult rat. Surg Forum 29: 402–404

    PubMed  CAS  Google Scholar 

  • Goodner CJ, Walike BC, Koerker DJ, Ensinck JW, Brown AC, Chideckel EW, Palmer J, Kalnasy L (1977) Insulin, glucagon and glucose exhibit synchronous, sustained oscillations in fasting monkeys. Science 195: 177–179

    PubMed  CAS  Google Scholar 

  • Grisham JW (1962) A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res 22: 842–849

    PubMed  CAS  Google Scholar 

  • Gurr J A, Ruh TA (1980) Desensitization of primary cultures of adult rat liver parenchymal cells to stimulation of adenosine 3′,5′-monophosphate production by glucagon and epinephrine. Endocrinology 107: 1309–1319

    PubMed  CAS  Google Scholar 

  • Hasegawa K, Koga M (1979) Relationship between the induction of DNA synthesis and changes in the concentration of intracellular Na+ in the liver of intact rats. J Physiol Soc Jpn 41: 282

    Google Scholar 

  • Hasegawa K, Namai K, Koga M (1980) Induction of DNA synthesis in adult rat hepatocytes cultured in a serum-free medium. Biochem Biophys Res Commun 95: 243–249

    PubMed  CAS  Google Scholar 

  • Hopkins HA, Bonney RJ, Walker PR, Yager JD Jr, Potter VR (1973) Food and light as separate entrainment signals for rat liver enzymes. Adv Enzyme Regul 11: 169–191

    PubMed  CAS  Google Scholar 

  • Ihlenfeldt MJA (1981) Stimulation of Rb+ transport by glucagon in isolated rat hepatocytes. J Biol Chem 256: 2213–2218

    PubMed  CAS  Google Scholar 

  • Katz N (1979) Correlation between rates and enzyme levels of increased gluconeogenesis in rat liver and kidney after partial hepatectomy. Eur J Biochem 98: 535–542

    PubMed  CAS  Google Scholar 

  • Kelley DS, Evanson T, Potter VR (1980) Calcium-dependent hormonal regulation of amino acid transport and cyclic AMP accumulation in rat hepatocyte monolayer cultures. Proc Natl Acad Sci USA 77: 5953–5957

    PubMed  CAS  Google Scholar 

  • Kiefer H, Blume A J, Kaback HR (1980) Membrane potential changes during mitogenic stimulation of mouse spleen lymphocytes. Proc Natl Acad Sci USA 77: 2200–2204

    PubMed  CAS  Google Scholar 

  • Kleinman HK, Klebe RJ Martin GR (1981) Role of collagenous matrices in the adhesion and growth of cells, J Cell Biol 88: 473–485

    PubMed  CAS  Google Scholar 

  • Koch K, Leffert HL (1974) Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. VI. Studies with conditioned medium and its functional interactions with serum factors. J Cell Biol 62: 780–791

    PubMed  CAS  Google Scholar 

  • Koch KS, Leffert HL (1979) Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation. Cell 18: 153–163

    PubMed  CAS  Google Scholar 

  • Koch KS, Leffert HL (1980) Growth regulation of adult rat hepatocytes in primary culture. Ann NY Acad Sci 349: 111–127

    PubMed  CAS  Google Scholar 

  • Koch KS, Leffert HL, Moran T (1976) Hepatic proliferation control by purines, hormones and nutrients. In: Fishman W, Sell S (eds) Oncodevelopment gene expression, 3rd meeting, International Study Group for Carcinoembryonic Proteins. Academic, New York London, pp 21–33

    Google Scholar 

  • Kreisberg RA, Williamson JR (1964) Metabolic effects of glucagon in the perfused rat heart. Am J Physiol 207: 721–727

    PubMed  CAS  Google Scholar 

  • Lad PJ, Brown JW, Blasquez E, Lin M, Koch KS, Skelly H, deHemptinne B, Leffert HL (1981) Adult rat hepatocytes in primary culture. VI. Lactate gluconeogenesis: developmental changes and glucagon-responsiveness during the growth cycle. Submitted Lambotte L (1977) Effect of anoxia and ATP depletion on the membrane potential and permeability of dog liver. J Physiol (Lond) 269: 53–70

    Google Scholar 

  • Langan TA (1976) Methods for the assessment of site-specific histone phosphorylation. Methods Cell Biol 19: 127–142

    Google Scholar 

  • Langman J (1963) Medical embryology. Williams & Wilkins, Baltimore

    Google Scholar 

  • LeCam A, Freychet P (1976) Glucagon stimulates the A system for neutral amino acid transport in isolated hepatocytes of adult rat. Biochem Biophys Res Commun 72: 893–901

    CAS  Google Scholar 

  • LeCam A, Freychet P (1977) Neutral amino acid transport. J Biol Chem 252: 148–156

    CAS  Google Scholar 

  • LeCam A, Rey JF, Fehlmann M, Kitabgi M, Freychet P (1979) Amino acid transport in isolated hepatocytes after partial hepatectomy in the rat. Am J Physiol 236: E594–E602

    CAS  Google Scholar 

  • Leduc EH (1949) Mitotic activity in the liver of the mouse during inanition followed by re-feeding with different levels of protein. Am J Anat 84: 397–430

    PubMed  CAS  Google Scholar 

  • Leffert HL (1974) Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. VII. Hormonal control of DNA synthesis and its possible significance to the problem of liver regeneration. J Cell Biol 62: 792–801

    PubMed  CAS  Google Scholar 

  • Leffert HL (1977) Glucagon, insulin, and their hepatic “receptors”: an endocrine pattern characterizing hepatoproliferative transitions in the rat. In: Foá PP, Bajaj JS, Foá NL (eds) Glucagon, its role in physiology and clinical medicine. Springer, Berlin Heidelberg New York, pp 305–319

    Google Scholar 

  • Leffert HL, Koch KS (1977) Control of animal cell proliferation. In: Rothblat GH, Cristofalo VJ (eds) Growth, nutrition and metabolism of cells in culture, vol 3. Academic, New York London San Francisco, pp 225–294

    Google Scholar 

  • Leffert HL, Koch KS (1978) Proliferation of hepatocytes. CIBA Found Symp 55: 61–94

    CAS  Google Scholar 

  • Leffert HL, Koch KS (1980) Ionic events at the membrane initiate rat liver regeneration. Ann NY Acad Sci 339: 201–215

    PubMed  CAS  Google Scholar 

  • Leffert HL, Koch KS (1981) Two ionic signals as prominent regulators of liver regeneration. In: Berk PD (ed) Frontiers of science and the liver. Thieme-Straton, New York

    Google Scholar 

  • Leffert HL, Paul D (1972) Studies on primary cultures of differentiated fetal liver cells. J Cell Biol 52: 559–568

    PubMed  CAS  Google Scholar 

  • Leffert HL, Weinstein DB (1976) Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. IX. Specific inhibition of DNA synthesis initiation by very low density lipoprotein and possible significance to the problem of liver regeneration. J Cell Biol 70: 20–32

    PubMed  CAS  Google Scholar 

  • Leffert H, Alexander MN, Faloona G, Rubalcava B (1975) Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats. Proc Natl Acad Sci USA 72: 4033–4036

    PubMed  CAS  Google Scholar 

  • Leffert HL, Koch KS, Rubalcava B (1976) Present paradoxes in the environmental control of hepatic proliferation. Cancer Res 36: 4250–4255

    PubMed  CAS  Google Scholar 

  • Leffert HL, Moran T, Boorstein R, Koch KS (1977) Procarcinogen activation and hormonal control of cell proliferation in differentiated primary adult rat liver cell cultures. Nature 267: 58–61

    PubMed  CAS  Google Scholar 

  • Leffert HL, Koch KS, Rubalcava B, Sell S, Moran T, Boorstein R (1978) Hepatocyte growth control: in vitro approach to problems of liver regeneration and function. Natl Cancer Inst Monogr 48: 87–101

    PubMed  Google Scholar 

  • Leffert HL, Koch KS, Moran T, Rubalcava B (1979) Hormonal control of rat liver regeneration. Gastroenterology 76: 1470–1482

    PubMed  CAS  Google Scholar 

  • Leffert HL, Koch KS, Lad PJ, Skelly H, de Hemptinne B (1982) Hepatocyte growth factors. In: Zakim D, Boyer TD (eds) Hepatology, chap 3, pp 64–75

    Google Scholar 

  • Leffert HL, Sell S, Skelly H, Moran T (1982 a) Adult rat hepatocytes in primary culture. XIII. N-acetyl-2-aminofluorene (AAF): multicycle characterization of short-term proliferative and functional properties of cells obtained from rats fed a carcinogenic diet. In preparation

    Google Scholar 

  • Leffert HL, Brown JW, Sela-Trepat J, Lad PJ, Sell S, Skelly H, Moran T (1982 b) Adult rat hepatocytes in primary culture. I X. A developmental program for the synthesis, secretion and turnover of albumin. In preparation

    Google Scholar 

  • Leong GF, Grisham JW, Hole BV, Albright ML (1964) Effect of partial hepatectomy on DNA synthesis and mitosis in heterotopic partial autografts of rat liver. Cancer Res 24: 1495–1501

    Google Scholar 

  • Lever JE, Kaback HR (1979) The use of membrane vesicles in transport studies. CRC Rev Biol 7: 187–246

    CAS  Google Scholar 

  • Lichtstein D, Kaback HR, Blume A J (1979) Use of a lipophilic cation for determination of membrane potential in neuroblastoma-glioma hybrid cell suspensions. Proc Natl Acad Sci USA 76: 650–654

    Google Scholar 

  • Livingston JN, Cuatrecasas P, Lockwood DH (1974) Studies of glucagon resistance in large rat adipocytes: 125I-labeled glucagon binding and lipolytic capacity. J Lipid Res 15: 26–32

    PubMed  CAS  Google Scholar 

  • Loewenstein WR (1979) Junctional intercellular communication and the control of growth. Biochim Biophys Acta 560: 1–65

    PubMed  CAS  Google Scholar 

  • MacManus JP, Whitfield JF (1981) Stimulation of autophosphorylation of liver cell membrane proteins by calcium and partial hepatectomy. J Cell Physiol 106: 33–40

    PubMed  CAS  Google Scholar 

  • MacManus JP, Braceland BM, Youdale T, Whitfield JF (1973) Adrenergic antagonists and a possible link between the increase in cyclic adenosine 3′: 5′-monophosphate and DNA synthesis during liver regeneration. J Cell Physiol 82: 157–164

    PubMed  CAS  Google Scholar 

  • Makowka L, Falk RE, Rotstein LE, Falk JA, Nossal N, Langer B, Blendis LM, Phillips MJ (1980) Cellular transplantation in the treatment of experimental hepatic failure. Science 210: 901–903

    PubMed  CAS  Google Scholar 

  • Marceau N, Goyette R, Dêschenes J, Valet JP (1980) Morphological differences between epithelial and fibroblast cells in rat liver cultures and the roles of cell surface fibronectin and cytoskeletal element organization in cell shape. Ann NY Acad Sci 349: 138–152

    PubMed  CAS  Google Scholar 

  • McGiff JC (1981) Prostaglandins, prostacyclin, and thromboxanes. Annu Rev Pharmacol Toxicol 21: 479–509

    PubMed  CAS  Google Scholar 

  • Morley LGD, Kuku S, Rubenstein AH (1975) Serum hormone levels following partial hepatectomy in the rat. Biochem Biophys Res Commun 67: 653–661

    PubMed  CAS  Google Scholar 

  • Mourelle M, Rubalcava B (1979) Changes in the insulin and glucagon receptors in the regenerating liver following intoxication with carbon tetrachloride. Biochem Biophys Res Commun 88: 189–198

    PubMed  CAS  Google Scholar 

  • Mourelle M, Rubalcava B (1981) Regeneration of the liver after carbon tetrachloride. J Biol Chem 256: 1656–1660

    PubMed  CAS  Google Scholar 

  • Nadal C (1979) Control of liver growth by growth inhibitors (chalones). Arch Toxicol [Suppl] 2: 131–142

    Google Scholar 

  • Pardee AB (1974) A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci USA 71: 1286–1290

    PubMed  CAS  Google Scholar 

  • Pariza MW, Butcher FR, Kletzien RF, Becker JE, Potter VR (1976) Induction and decay of glucagon-induced amino acid transport in primary cultures of adult rat liver cells. Proc Natl Acad Sci USA 73: 4511–4515

    PubMed  CAS  Google Scholar 

  • Paul D, Walter S (1975) Growth control in primary fetal rat liver cells in culture. J Cell Physiol 85: 113–123

    PubMed  CAS  Google Scholar 

  • Petersen OH (1974) The effect of glucagon on the liver cell membrane potential. J Physiol (Lond) 239: 647–656

    CAS  Google Scholar 

  • Pilkis SJ, Park CR, Claus TH (1978) Hormonal control of hepatic gluconeogenesis. Vitam Horm 36: 383–460

    PubMed  CAS  Google Scholar 

  • Pollard TD, Weihing RR (1974) Actin and myosin and cell movement. CRC Crit Rev Biochem 2: 1–65

    PubMed  CAS  Google Scholar 

  • Post RL, Merritt CR, Kinsolving CR, Albright CD (1960) Membrane adenosine triphosphatase as a participant in the active transport of sodium and potassium in the human erythrocyte. J Biol Chem 235: 1796–1802

    PubMed  CAS  Google Scholar 

  • Potter S, Moran T, Leffert HL (1982) Selective hepatic uptake of 125I-labelled epidermal growth factor following partial hepatectomy in the adult rat. In preparation Pressman BC (1976) Biological applications of ionophores, Annu Rev Biochem 45: 501–530

    Google Scholar 

  • Price JB (1976) Insulin and glucagon as modifiers of DNA synthesis in regenerating rat liver. Metabolism 25: 1427–1428

    PubMed  CAS  Google Scholar 

  • Price JB, Takeshige K, Max MH, Voorhees AB (1972) Glucagon as the portal factor modifying hepatic regeneration. Surgery 72: 74–82

    PubMed  Google Scholar 

  • Rabes HM (1978) Kinetics of hepatocellular proliferation as a function of the microvascular structure and functional state of the liver. CIBA Found Symp 55: 31–53

    Google Scholar 

  • Richman RA, Claus TH, Pilkis SJ, Friedman DL (1976) Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes. Proc Natl Acad Sci USA 73: 3589–3593

    PubMed  CAS  Google Scholar 

  • Rodbell M (1980) The role of hormone receptors and GTP-regulatory proteins in membrane transduction. Nature 284: 17–22

    PubMed  CAS  Google Scholar 

  • Sakai A (1970) Humoral factor triggering DNA synthesis after partial hepatectomy in the rat. Nature 228: 1186

    PubMed  CAS  Google Scholar 

  • Scheving LA, Yeh YC, Tsai TH, Scheving LE (1980) Circadian phase-dependent stimulatory effects of epidermal growth factor on deoxyribonucleic acid synthesis in the duodenum, jejunum, ileum, cecum, colon, and rectum of the adult male mouse. Endocrinology 106: 1498–1503

    PubMed  CAS  Google Scholar 

  • Schreiber G, Urban J, Zähringer J, Reutter W, Frosh U (1971) The secretion of serum protein and the synthesis of albumin and total protein in regenerating liver. J Biol Chem 246: 4531–4538

    PubMed  CAS  Google Scholar 

  • Scornik OA (1972) Decreased in vivo disappearance of labelled liver protein after partial hepatectomy. Biochem Biophys Res Commun 47: 1063–1066

    PubMed  CAS  Google Scholar 

  • Seals JR, Czech MP (1980) Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator. J Biol Chem 255: 6529–6531

    PubMed  CAS  Google Scholar 

  • Sell S, Nichols M, Becker FF, Leffert HL (1974) Hepatocyte proliferation and α1-fetoprotein in pregnant, neonatal, and partially hepatectomized rats. Cancer Res 34: 865–871

    PubMed  CAS  Google Scholar 

  • Sell S, Osborn K, Leffert HL (1981) Autoradiography of oval cells appearing rapidly in the livers of rats fed N-2-fluorenylactamide in a choline-devoid diet. Carcinogenesis 2: 7–14

    PubMed  CAS  Google Scholar 

  • Sherwin RS, Fisher M, Bessof J, Snyder N, Hendler R, Conn HO, Felig P (1978) Hyperglucagonemia in cirrhosis: altered secretion and sensitivity to glucagon. Gastroenterology 74: 1224–1228

    PubMed  CAS  Google Scholar 

  • Short J, Brown RF, Husakova A, Gilbertson JR, Zemel R, Lieberman I (1972) Induction of DNA synthesis in the liver of the intact animal. J Biol Chem 247: 1757–1766

    PubMed  CAS  Google Scholar 

  • Short J, Armstrong NB, Zemel R, Lieberman I (1973) A role for amino acids in the induction of deoxyribonucleic acid synthesis in liver. Biochem Biophys Res Commun 50: 430–437

    PubMed  CAS  Google Scholar 

  • Sigel B, Baldia LB Brightman SA, Dunn MR, Price RIM (1968) Effect of blood flow reversal in liver autotransplants upon the site of hepatocyte regeneration. J Clin Invest 46: 1231–1237

    Google Scholar 

  • Slater TF (ed) (1978) Biochemical mechanisms of liver injury. Academic, London New York

    Google Scholar 

  • Sobieszk A, Bremel RD (1975) Preparation and properties of vertebrate smooth-muscle myofibrils and actomyosin. Eur J Biochem 55: 49–60

    Google Scholar 

  • Somlyo AP, Somlyo AV, Friedmann N (1971) Cyclic adenosine monophosphate, cyclic guanosine monophosphate and glucagon: effects on membrane potential and ion fluxes in the liver. Ann NY Acad Sci 185: 108–114

    PubMed  CAS  Google Scholar 

  • Starzl TE, Porter KA, Watanabe K, Putnam CW (1976) Effects of insulin, glucagon, and insulin/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs. Lancet 1: 821–825

    PubMed  CAS  Google Scholar 

  • Steiner JW, Carruthers JS (1961) Studies of the fine structure of the terminal branches of the biliary tree. I. The morphology of normal bile canaliculi, bile preductules (Ducts of Hering) and bile ductules, Am J Pathol 6: 639–661

    Google Scholar 

  • Strecker W, Goldberg M, Feeny DA, Ruhenstroth-Bauer G (1976) The influence of extended glucagon infusion on liver cell regeneration after partial hepatectomy in the rat. Acta Hepatogastroenterol (Stuttg) 26: 439–441

    Google Scholar 

  • Terpstra OT, Malt RA, Bucher NLR (1979) Negligible role of adrenal hormones in regulation of DNA synthesis in liver of partially hepatectomized rats. Proc Soc Exp Biol Med 161: 326–331

    PubMed  CAS  Google Scholar 

  • Timpl R, Rohde H, Robey PG, Renard SI, Foidart JM, Martin GR (1979) Laminin - a glycoprotein from basement membranes. J Biol Chem 254: 9933–9937

    PubMed  CAS  Google Scholar 

  • Wang K, Ash JF, Singer SJ (1975) Filamin, a new high molecular weight protein found in smooth muscle and non-muscle cells. Proc Natl Acad Sci USA 72: 4483–3386

    PubMed  CAS  Google Scholar 

  • Whitfield JF, Boynton AL, MacManus JP, Rixon RH, Sikorska M, Tsang B, Walker RR (1980) The roles of calcium and cyclic AMP in cell proliferation. Ann NY Acad Sci 339: 216–240

    PubMed  CAS  Google Scholar 

  • Wondergem R, Harder DR (1980) Membrane potential measurements during rat liver regeneration. J Cell Physiol 102: 193–197

    PubMed  CAS  Google Scholar 

  • Yamada KM, Olden K (1978) Fibronectins-adhesive glycoproteins of cell surface and blood. Nature 275: 179–184

    PubMed  CAS  Google Scholar 

  • Yeoh G, Oliver IT (1971) A stimulatory effect of glucagon on DNA synthesis in neonatal rat liver. Comp Biochem Physiol [A] 39: 723–733

    CAS  Google Scholar 

  • Zapf J, Rinderknecht E, Humbel RE (1978) Nonsuppressible insulin-like activity (NSILA) from human serum: recent accomplishments and their physiologic implication. Metabolism 27: 1803–1827

    PubMed  CAS  Google Scholar 

  • Zucker S, Lysik RM, Chikkappa G, Glucksman MJ, Gomez-Reino J, Distefano JF (1980) Very low density lipoprotein hematopoiesis inhibitor from rat plasma. J Cell Sci 8: 895–905

    CAS  Google Scholar 

Download references

Authors
  1. H. L. Leffert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. S. Koch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. J. Lad
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. De Hemptinne
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Skelly
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Mèdecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Leffert, H.L., Koch, K.S., Lad, P.J., De Hemptinne, B., Skelly, H. (1983). Glucagon and Liver Regeneration. In: Lefèbvre, P.J. (eds) Glucagon I. Handbook of Experimental Pharmacology, vol 66 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68866-9_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68866-9_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68868-3

  • Online ISBN: 978-3-642-68866-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation