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The Chemical Synthesis of Glucagon

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Glucagon I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 1))

Abstract

With the determination of the complete amino acid sequence of porcine glucagon by BROMER et al. (1957), the way was open for the chemical synthesis of this important peptide hormone. A synthesis would serve several purposes: it would, first of all, provide a classical proof of the proposed structure; secondly, it could lead to a large scale source of the hormone to replace the natural material, and, especially, it would provide a route to structural analogs designed to be inhibitors or superagonists that would be useful, both in defining the mechanism of action of glucagon and as potential clinical agents.

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Authors
  1. R. B. Merrifield
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  2. S. Mojsov
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Editor information

Editors and Affiliations

  1. University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Mèdecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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© 1983 Springer-Verlag Berlin Heidelberg

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Merrifield, R.B., Mojsov, S. (1983). The Chemical Synthesis of Glucagon. In: Lefèbvre, P.J. (eds) Glucagon I. Handbook of Experimental Pharmacology, vol 66 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68866-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-68866-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68868-3

  • Online ISBN: 978-3-642-68866-9

  • eBook Packages: Springer Book Archive

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