Glucagon I pp 419-440 | Cite as

Glucagon and Adipose Tissue Lipolysis

  • P. J. Lefebvre
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 66 / 1)


Although discovered much later than its effects on carbohydrate metabolism, the action of glucagon on adipose tissue lipolysis seems particularly relevant and its importance in physiology has been stressed in various reviews and monographs (Lefebvre 1966a, 1967, 1972, 1975; Weinges 1968; F 1968; Felig 1970; Lefebvre and Luyckx 1971; Schade et al. 1979; Unger 1981). In the present chapter, we will discuss the effects of glucagon on adipose tissue and on circulating free fatty acids (FFA) and attempt to delineate the physiologic importance of these phenomena.


Adipose Tissue Brown Adipose Tissue Plasma Glucagon Lipolytic Effect Free Fatty Acid Release 
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  1. Allen DO, Gardner EA (1979) Antilipolytic action of insulin in the perifused fat cell system. Biochem Pharmacol 617–622Google Scholar
  2. Amstrong KJ, Stouffer JE, Van Iwegen RG, Thompson WJ, Robison GA (1974) Effect of thyroid hormone deficiency on cyclic adenosine 3′:5′-monophosphate and control of lipolysis in fat cells. J Biol Chem 249: 4226–4231Google Scholar
  3. Bär HP, Hechter O (1969) Adenylcyclase and hormone action. I. Effects of adrenocorticotropic hormone, glucagon and epinephrine on the plasma membrane of the rat fat cell. Proc Natl Acad Sci USA 63: 350–356PubMedGoogle Scholar
  4. Belfiore F (1980) Enzyme regulation and metabolic diseases. Karger, Basel, New YorkGoogle Scholar
  5. Belfiore F, Rabuazzo AM, Borzi V, Iannello S (1981) Regulation of two key-enzymes involved in triglyceride synthesis in human adipose tissue: phosphofructokinase and phosphatidate phosphatase (Abstr). Third European Symposium on Metabolism, Padua May 28–30, p 17Google Scholar
  6. Bergström S, Carlson LA (1965) Inhibitory action of prostaglandin E1 on the mobilization of free fatty acids and glycerol from human adipose tissue in vitro. Prostaglandin and related factors. Acta Physiol Scand 63: 195–196Google Scholar
  7. Bertrand HA, Masoro EJ, Byung PYU (1980) Maintenance of glucagon-promoted lipolysis in adipocytes by food restriction. Endocrinology 107: 591–595PubMedGoogle Scholar
  8. Bierman E, Dole VP, Roberts TN (1957) An abnormality of non esterified fatty acid metabolism in diabetes mellitus. Diabetes 6: 475–479PubMedGoogle Scholar
  9. Birnbaumer L, Rodbell M (1969) Adenylcyclase in fat cell. II: Hormone receptor. J Biol Chem 244: 3477–3482Google Scholar
  10. Björntorp P, Karlsson M, Hovden A (1969) Quantitative aspects of lipolysis and reesterifaction in human adipose tissue in vitro. Acta Med Scand 185: 89–97PubMedGoogle Scholar
  11. Blecher M, Merlino NS, Ro’Ane JT, Flynn PD (1969) Independance of the effects of epinephrine, glucagon and adrenocorticotropin on glucose utilization from those of lipolysis in isolated rat adipose cells. J Biol Chem 244: 3423–3429PubMedGoogle Scholar
  12. Boberg J, Micheli H, Rammer L (1970) Effect of nicotinic acid on ACTH and noradrenaline stimulated lipolysis in the rabbit. II. In vitro studies including comparison with Prostaglandin E1. Acta Physiol Scand 79: 299–304Google Scholar
  13. Borensztajn J, Keig P, Rubenstein AH (1973) The role of glucagon in the regulation of myocardial lipoprotein lipase activity. Biochem Biophys Res Commun 53: 603–608PubMedGoogle Scholar
  14. Boyd TA, Wieser PB, Fain JN (1975) Lipolysis and cyclic AMP accumulation in isolated fat cells from chicks. Gen Comp Endocrinol 26: 243–247PubMedGoogle Scholar
  15. Brockman RP, Bergman EN, Joo PK, Manns JG (1975) Effects of glucagon and insulin on net hepatic metabolism of glucose precursors in sheep. Am J Physiol 229: 1344–1350PubMedGoogle Scholar
  16. Butcher RW, Ho RJ, Meng HC, Sutherland EW (1965) Adenosine 3′, 5′-monophosphate in biological materials. II. The measurement of adenosine 3′, 5′-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine. J Biol Chem 240: 4515–4523PubMedGoogle Scholar
  17. Camu F (1969 a) Effects of imidazole and cyanide upon rat adipose tissue lipolysis. Arch Int Physiol Biochim 77:663–669PubMedGoogle Scholar
  18. Camu F (1969 b) Interactions du glucagon, de l’insuline et du glucose sur la lipolyse de tissus adipeux de rats in vitro. Arch Int Pharmacodyn Ther 178:370–381PubMedGoogle Scholar
  19. Chlouverakis C (1967) The action of glucose on lipolysis. Metabolism 16: 469–472PubMedGoogle Scholar
  20. Chohan P, Saggerson D (1982) Increased sensitivity of adipocyte adenylate cyclase to glucagon in the fasted state. FEBS Lett 146: 357–360PubMedGoogle Scholar
  21. Christ EJ, Nugteren DH (1970) The biosynthesis and possible function of prostaglandins in adipose tissue. Biochim Biophys Acta 218: 296–307Google Scholar
  22. Cockburn F, Hull D, Walton I (1968) The effect of lipolytic hormones and theophylline on heart production in brown adipose tissue in vitro. Br J Pharmacol 31: 568–577Google Scholar
  23. Cooper B, Weinblatt F, Gregerman RI (1977) Enhanced activity of hormone-sensitive adenylate cyclase during dietary restriction in the rat: dependance on age and relation to cell size. J Clin Invest 59: 467–474PubMedGoogle Scholar
  24. Dalton C, Hope HH (1973) Inability of prostaglandin synthesis inhibition to affect adipose tissue lipolysis. Prostaglandins 4: 461–651Google Scholar
  25. de Oya M, Prigge WF, Grande F (1971) Suppression by hepatectomy of glucagon-induced hypertriglyceridemia in geese. Proc Soc Exp Biol Med 136: 107–110PubMedGoogle Scholar
  26. De Plaen J, Galansino G (1966) Effect of glucagon and epinephrine in fasted dogs. Proc Soc Exp Biol Med 121: 501–504PubMedGoogle Scholar
  27. De Santis RA, Gorenstein T, Livingston JN, Lockwood DH (1974) Role of phosphodiesterase in glucagon resistance of large adipocytes. J Lipid Res 15: 33–38PubMedGoogle Scholar
  28. Desbals P, Miahle P, Desbals B (1970) Sensitivity of avian adipose tissue to lipolytic hormones (Abstr). Diabetologia 6: 625Google Scholar
  29. Dreiling DA, Bierman EL (1957) Correlation between plasma amylase activity and concentration of non esterified fatty acids (NEFA). Proc Soc Exp Biol Med 95: 496–497PubMedGoogle Scholar
  30. Dreiling DA, Bierman EL, Debons AF, Elsbach P, Schwartz IL (1962) Effect of ACTH, hydrocortisone and glucagon on plasma non esterified fatty acid concentration (NEFA) in normal subjects and in patients with liver disease. Metabolism 11: 572–578PubMedGoogle Scholar
  31. Fain JN, Kovacev VP, Scow RO (1966) Antilipolytic effect of insulin on isolated fat cells of the rat. Endocrinology 78: 773–778PubMedGoogle Scholar
  32. Fain JN, Psychoyos S, Czernik AJ, Frost S, Cash WD (1973) Indomethacin, lipolysis and cyclic AMP accumulation in white fat cells. Endocrinology 93: 632–639PubMedGoogle Scholar
  33. Felig P (1970) Glucagon: physiologic and diabetogenic role. N Engl J Med 283: 149–150PubMedGoogle Scholar
  34. Fernandez BM, Saggerson ED (1978) Alteration in response of rat white adipocytes to insulin, noradrenalin, corticotropin and glucagon after adrenalectomy. Correction of these changes by adenosine deaminase. Biochem J 174: 111–118PubMedGoogle Scholar
  35. Foà PP (1968) Glucagon. Ergeb Physiol 60: 141–219Google Scholar
  36. Frandsen EK, Grønvald FC, Heding LG, Johansen NL, Lundt BF, Moody AJ, Markussen J, Volund AA (1981) Glucagon: structure-function relationships investigated by sequence deletions. Hoppe-Seylers Z Physiol Chem 362: 665–667PubMedGoogle Scholar
  37. Fredholm BB, Hedqvist P (1975) Indomethacin and the role of prostaglandins in adipose tissue. Biochem Pharmacol 24: 61–66PubMedGoogle Scholar
  38. Friedli C, Chinet A, Girardier L (1978) Comparative measurements of in vitro thermogenesis of brown adipose tissue from control and cold-adapted rats. Experientia [suppl] 32: 259–266Google Scholar
  39. Froesch E, Bally P, Guhl U, Ramseier E, Labhart A (1960) Die Wirkung des Glukagons auf die Fettgewebe. Schweiz Med Wochenschr 90: 1329–1332PubMedGoogle Scholar
  40. Gaion RM (1981) Calcium and cyclic GMP as an alternative control system in fat cell metabolism. In: Enzi G, Crepaldi G, Pozza G, Renold AE (eds) Obesity: pathogenesis and treatment. Academic, New York London, pp 149–160Google Scholar
  41. Gaion RM, Krishna G (1981) The role of cyclic nucleotides in the regulation of lipolysis. In: Enzi G, Crepaldi G, Pozza G, Renold AE (eds) Obesity: pathogenesis and treatment. Academic, New York London, pp 135–148Google Scholar
  42. Gascon S (1971) Influencia de la prostaglandin El en el control hormonal de la lipolisis en aves. Rev Esp Fisiol 27: 69–72PubMedGoogle Scholar
  43. Gerich JE, Lorenzi M, Bier D, Taslikian E, Schneider V, Karam JH, Forsham PH (1976) Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin. J Clin Invest 57: 875–884PubMedGoogle Scholar
  44. Ghidoni A, Pappalettera A, Sanesi E, Tognetti A, Pozza G (1970) Metabolismo di cellule adipose umane isolate in vitro. II. Regolazione della lipolisi. Acta Diabetol Lat 7: 271–278PubMedGoogle Scholar
  45. Goodrige AG, Ball EG (1965) Studies on the metabolism of adipose tissue: XVIII: In vitro effects of insulin, epinephrine and glucagon on lipolysis and glycolysis in pigeon’s adipose tissue. Comp Biochem Physiol 16: 367–381Google Scholar
  46. Gorin E, Goodman HM (1974) Protein kinase in adipose tissue: effect of hypophysectomy. Horm Metab Res 6: 146–150PubMedGoogle Scholar
  47. Grande F, Prigge WF (1970) Glucagon infusion, plasma FFA and triglycerides, blood sugar and liver lipids in birds. Am J Physiol 218: 1406–1411PubMedGoogle Scholar
  48. Grande F, Prigge WF (1972) Influence of prostaglandin E1 on the adipokinetic effect of glucagon in birds. Proc Soc Exp Biol Med 140: 999–1004PubMedGoogle Scholar
  49. Gries FA (1968) Wirkungen von Glukagon auf den Stoffwechsel des Fettgewebes. In: 14. Symposion der Deutschen Gesellschaft für Endokrinologie. Springer, Berlin Heidelberg New York, pp 235–241Google Scholar
  50. Gutman RA, Fink G, Voyles N, Selawry H, Penhos JC, Lepp A, Recant L (1973) Specific biologic effects of intestinal glucagon-like materials. J Clin Invest 52: 1165–1175PubMedGoogle Scholar
  51. Hagen JH (1961) Effects of glucagon on the metabolism of adipose tissue. J Biol Chem 236: 1023–1027PubMedGoogle Scholar
  52. Heald PJ, McLachlan PM, Rookledge KA (1965) The effect of insulin, glucagon and adrenocorticotrophic hormone on the plasma glucose and free fatty acids of the domestic fowl. J Endocrinol 33: 83–95PubMedGoogle Scholar
  53. Heckemeyer CM, Barker J A, Duckworth WC, Solomon SS (1981 a) Lipolytic effect of glucagon on perifused isolated fat cells. Clin Res 29:505AGoogle Scholar
  54. Heckemeyer CM, Barker JA, Duckworth WC, Solomon SS (1981 b) Glucagon degradation by the perifused isolated fat cell. Diabetes [Suppl] 30:105AGoogle Scholar
  55. Heim T, Hull D (1966) The effects of propranolol on the calorigenic response in brown adipose tissue of newborn rabbits to catecholamines, glucagon, corticotrophin and cold exposure. J Physiol (Lond) 187: 271–283Google Scholar
  56. Hoak JC, Connor WE, Warner ED (1968) Toxic effects of glucagon-induced acute lipid mobilization in geese. J Clin Invest 47: 2701–2710PubMedGoogle Scholar
  57. Holm G, Jacobsson B, Björntorp P, Smith U (1975) Effect of age and cell size on rat adipose tissue metabolism. J Lipid Res 16: 461–464PubMedGoogle Scholar
  58. Honnor RC, Saggerson ED (1980) Altered lipolytic response to glucagon and adenosine deaminase in adipocytes from starved rats. Biochem J 188: 757–761PubMedGoogle Scholar
  59. Horton EW (1969) Hypotheses on physiological roles of prostaglandins. Physiol Rev 49: 122–161PubMedGoogle Scholar
  60. Iliano G, Cuatrecasas P (1971) Endogenous prostaglandins modulate lipolytic processes in adipose tissue. Nature New Biol 234: 72–74Google Scholar
  61. Joel CD (1966) Stimulation of metabolism of rat brown adipose tissue by addition of lipolytic hormones in vitro. J Biol Chem 241: 814–821PubMedGoogle Scholar
  62. Koerker DJ, Goodner CJ, Koivola PTK, Gale CC, Ensinck JW (1974) Adaptation to fasting in baboon. I. Influence of feeding schedule. Am J Physiol 227: 520–530PubMedGoogle Scholar
  63. Krug E, Miahle P (1979) A possible role for gut GLI: an inhibitor of lipolysis. Horm Metab Res 6: 465–469Google Scholar
  64. Kuroshima A, Yahata T (1979) Thermogenic responses of brown adipocytes to noradrenaline and glucagon in heat-acclimated and cold-acclimated rats. Jpn J Physiol 29:683–690PubMedGoogle Scholar
  65. Kuroshima A, Doi K, Kurahashi M, Ohno T (1975) In vivo lipolytic effect of glucagon in warm-adapted and cold-adapted rats. Jpn J Physiol 25: 275–285PubMedGoogle Scholar
  66. Kuroshima A, Ohno T, Doi K (1977) In vivo lipolytic action of glucagon in brown adipose tissue of warm-acclimatized and cold-acclimatized rats. Experientia 33: 240–241PubMedGoogle Scholar
  67. Langslow DR (1971) The antilipolytic action of prostaglandin Ex on isolated fat cells. Biochim Biophys Acta 239:33–37PubMedGoogle Scholar
  68. Langslow DR (1972) The development of lipolytic sensitivity in the isolated fat cells of Gallus domesticus during the foetal and neonatal period. Comp Biochem Physiol [B] 43:689–701Google Scholar
  69. Langslow DR, Hales CN (1969) Lipolysis in chicken adipose tissue in vitro. J Endocrinol 43: 285–294PubMedGoogle Scholar
  70. Langslow DR, Hales CN (1970) Bioassay of glucagon in human serum. Lancet 1: 1151–1152PubMedGoogle Scholar
  71. Langslow DR, Gramb G, Siddle K (1979) Possible mechanisms for the increased sensitivity to glucagon and catecholamines of chicken adipose tissue during hatching. Gen Com Endocrinol 39: 527–533Google Scholar
  72. Lee HM, Ellis RM, Bromer WW (1960) Insulin-like effect of crystalline glucagon as mea-sured with epididymal fat pad preparation. Proc Soc Exp Biol Med 104: 4–6PubMedGoogle Scholar
  73. Lefèbvre P (1965) Glucagon et taux sanguin des acides gras non estérifiés chez l’Homme. Ann Endocrinol (Paris) 26: 602–608Google Scholar
  74. Lefèbvre P (1966 a) Contribution à l’etude du rôle physiologique du glucagon. Arscia, BrusselsGoogle Scholar
  75. Lefèbvre P (1966 b) The physiological effect of glucagon on fat mobilization. Diabetologia 2:130–132PubMedGoogle Scholar
  76. Lefèbvre P (1967) Le glucagon, seconde hormone pancréatique. Maloine, Paris, Arscia, BrusselsGoogle Scholar
  77. Lefèbvre P (1972) Glucagon and lipid metabolism. In: Lefèbvre PH, Unger RH (eds) Glucagon: molecular physiology, clinical and therapeutic implications. Pergamon, Oxford New York, pp 109–121Google Scholar
  78. Lefèbvre PJ (1975) Commentary: glucagon and adipose tissue. Biochem Pharmacol 24: 1261–1266PubMedGoogle Scholar
  79. Lefèbvre PJ, Federspil G (1971) Effets d’un exercise musculaire continu (nage forcee) sur le métabolisme du tissu adipeux du rat. Arch Int Physiol Biochim 79: 565–572PubMedGoogle Scholar
  80. Lefèbvre P, Luyckx A (1969 a) Lipolytic action of glucagon in vitro and in vivo. In: Vague J (ed) Physiopathology of adipose tissue. Excerpta Medica, Amsterdam London New York, pp 257–267Google Scholar
  81. Lefèbvre P, Luyckx A (1969 b) Effect of insulin on glucagon-enhanced lipolysis in vitro. Diabetologia 5:195–197PubMedGoogle Scholar
  82. Lefèbvre P, Luyckx A (1971) The role of glucagon in clinical medicine. In: Foà PP (ed) The action of hormones: genes to population. Thomas, Springfield, pp 315–351Google Scholar
  83. Lefèbvre PJ, Luyckx AS (1974) Effect of L8027, a new potent inhibitor of prostaglandin biosynthesis, on the metabolism and response to glucagon of rat adipose tissue. Biochem Pharmacol 23: 2119–2125PubMedGoogle Scholar
  84. Lefèbvre PJ, Unger RH, Valverde I, Rigopoulou D, Luyckx AS, Eisentraut A (1969) Effect of dog jejenum “glucagon-like immunoreactive material” on adipose tissue metabolism. Horm Metab Res 1: 14–144PubMedGoogle Scholar
  85. Lefèbvre PJ, Luyckx AS, Federspil G (1972) Muscular exercise and pancreatic function in rats. Isr J Med Sci 8: 390–398PubMedGoogle Scholar
  86. Lefèbvre PJ, Luyckx AS, Bacq ZM (1973) Effects of denervation on the metabolism and the response to glucagon of white adipose tissue of rats. Horm Metab Res 5: 245–250PubMedGoogle Scholar
  87. Lewis GP, Matthews J (1968) The mobilization of free fatty acids from rabbit adipose tissue in situ. Br J Pharmacol 34: 564–578PubMedGoogle Scholar
  88. Liljenquist JE, Bomboy JD, Lewis SB, Sinclair-Smith BC, Felts PW, Lacy WW, Crofford OB, Liddle GW (1974) Effects of glucagon on lipolysis and ketogenesis in normal and diabetic men. J Clin Invest 53: 190–197PubMedGoogle Scholar
  89. Lipinski BA, Mathias MM (1978) Prostaglandin production and lipolysis in isolated rat adipocytes as affected by dietary fat. Prostaglandins 16: 957–963PubMedGoogle Scholar
  90. Livingston JN, Cuatrecasas P, Lockwood DH (1974) Studies of glucagon resistance in large adipocytes: 125I-labeled glucagon binding and lipolytic activity. J Lipid Res 15: 26–32PubMedGoogle Scholar
  91. Luyckx A (1974) Etude de la sécrétion de l’insuline et du glucagon. Thesis, University of LiègeGoogle Scholar
  92. Luyckx AS, Lefèbvre PJ (1973) Exercise-induced glucagon secretion. Postgrad Med J 49: 620–623Google Scholar
  93. Luyckx AS, Lefèbvre PJ (1974) Mechanisms involved in the exercise-induced increase in glucagon secretion in rats. Diabetes 23: 81–91PubMedGoogle Scholar
  94. Luyckx AS, Dresse A, Cession-Fossion A, Lefèbvre PJ (1975) Catecholamines and exercise-induced glucagon and fatty acid mobilization in the rat. Am J Physiol 229: 376–383PubMedGoogle Scholar
  95. Luyckx AS, Giugliano D, Lefèbvre PJ (1980) Influence of glucagon on the metabolic abnormalities of insulin-dependent diabetics. In: Waldhausl WK (ed) Diabetes 1979. Excerpta Medica, Amsterdam London New York, pp 409–414Google Scholar
  96. Maickel RP, Stern DN, Takabatake E, Brodie BB (1967) The sympathetic nervous system as a homeostatic mechanism. II. Effect of adrenocortical hormones on body temperature maintencance of cold-exposed adrenalectomized rats. J Pharmacol 157: 111–116Google Scholar
  97. Manganiello V, Vaughan M (1973) Selective loss of adipose cell responsiveness to glucagon with growth in the rat. J Lipid Res 13: 12–16Google Scholar
  98. Margolis S, Vaughan M (1962) α-glycerophosphate synthesis and breakdown in homogenates of adipose tissue. J Biol Chem 237:44–48PubMedGoogle Scholar
  99. Micheli H (1970) Some characteristics of lipolysis in rabbit adipose tissue. Effects of noradrenaline, ACTH, theophylline and prostaglandin E1 Acta Physiol Scand 79: 289–298Google Scholar
  100. Micheli H, Carlson LA, Hallberg D (1969) Comparison of lipolysis in human subcutaneous and omental adipose tissue with regard to effects of noradrenaline, theophylline, prostaglandin E1 and AGE. Acta Chir Scand 135: 663–670PubMedGoogle Scholar
  101. Mosinger B, Kuhn E, Kujalova V (1965) Actions of adipokinetic hormones on human adipose tissue in vitro. J Lab Clin Med 66: 380–389PubMedGoogle Scholar
  102. Mülbachova E, Solyom AL, Puglisi L (1967) Investigations on the mechanism of the prostaglandin Ex antagonism to norepinephrine and theophylline-induced lipolysis. Eur J Pharmacol 1: 321–325Google Scholar
  103. Müller WA, Aoki TT, Egdahl RH, Cahill GF Jr (1977) Effects of exogenous glucagon and epinephrine in physiological amounts on the blood levels of free fatty acids and glycerol in dogs. Diabetologia 13: 55–58PubMedGoogle Scholar
  104. Murase T, Tanaka K, Iwamoto Y, Akanuma Y, Kosaka K (1981) Reciproqual changes caused by insulin and glucagon of adipose tissue lipoprotein lipase in rats in vitro. Horm Metab Res 13: 212–213PubMedGoogle Scholar
  105. Nestel PJ, Austin W (1969) Relationship between adipose tissue lipase activity and compounds which affect intracellular lipolysis. Life Sci 8: 157–164PubMedGoogle Scholar
  106. Nyberg G, Häger A, Smith U (1977) Effect of age on human adipose tissue metabolism and hormonal responsiveness. Acta Paediatr Scand 66: 495–500PubMedGoogle Scholar
  107. Pozefsky T, Tancredi RG, Moxley RT, Dupre J, Tobin JD (1976) Metabolism of forearm tissues in man. Studies with glucagon. Diabetes 25: 128–135PubMedGoogle Scholar
  108. Pozza G, Pappalettera A, Ghidoni A, Sanesi E, Tognetti A, Melogli O (1971a) La regolazione dell lipolisi nel tessuto adiposo humano, con particolare riguardo allazione del glucagone. In: Austoni M, Scandellari C, Federspil G, Trisotto A (eds) Current topics on glucagon. Cedam, Padova, pp 93–105Google Scholar
  109. Pozza G, Pappalettera A, Melogli O, Viberti G, Ghidoni A (1971 b) Lipolytic effect of intraarterial injection of glucogon in man. Horm Metab Res 3:291–292PubMedGoogle Scholar
  110. Prigge WF, Grande F (1971) Effects of glucagon, epinephrine and insulin on in vitro lipolysis of adipose tissue from mammals and birds. Comp Biochem Physiol 39B: 69–82Google Scholar
  111. Ramwell PW, Shaw JE (1970) Biological significance of the prostaglandins. Recent Prog Horm Res 26: 139–187PubMedGoogle Scholar
  112. Ramwell PW, Shaw JE, Douglas WW, Poisner AM (1966) Efflux of prostaglandin from adrenal glands stimulated with acetlycholine. Nature 210: 273–274PubMedGoogle Scholar
  113. Rault C, Fruchart JC, Dewailly P, Jaillard J, Sezille G (1974) Experimental studies of myocardial and adipose tissue lipoprotein lipase activities in rat. Biochem Biophys Res Comm 59: 160–166PubMedGoogle Scholar
  114. Rodbell M, Jones AB (1966) Metabolism of isolated fat cells. Ill: The similar inhibitory action of phospholipase C (Clostridium perfringens a toxin) and of insulin on lipolysis stimulated by lipolytic hormones and theophylline. J Biol Chem 241: 140–142PubMedGoogle Scholar
  115. Rodbell M, Birnbaumer L, Pohl SL (1970) Adenylcyclase in fat cells. Stimulation by secretin and the effects of trypsin on the receptors for lipolytic hormones. J Biol Chem 245: 718–718PubMedGoogle Scholar
  116. Rudman D, Di Girolamo M (1967) Comparative studies on the physiology of adipose tissue. Adv Lipid Res 5: 35–117PubMedGoogle Scholar
  117. Samols E, Tyler JM, Marks V, Miahle P (1969) The physiological role of glucagon in different species. In: Gual C (eds) Progress in endocrinology. Excerpta Medica, Amsterdam London New York, pp 206–219Google Scholar
  118. Schade DS, Eaton RP (1975ga) The contribution of endogenous insulin secretion to the ketogenic response to glucagon in man. Diabetologia 11:555–559Google Scholar
  119. Schade DS, Eaton RP (1975 b) Modulation of fatty acid metabolism by glucagon in man. I. Effects in normal subjects. Diabetes 24: 502–509PubMedGoogle Scholar
  120. Schade DS, Woodside W, Eaton RH (1979) The role of glucagon in the regulation of plasma lipids. Metabolism 28: 874–886PubMedGoogle Scholar
  121. Schneider SH, Fineberg SE, Blackburn GL (1981) The acute metabolic effects of glucagon and its interactions with insulin in forearm tissue. Diabetologia 20: 616–624PubMedGoogle Scholar
  122. Shafrir E, Steinberg D (1960) The essential role of the adrenal cortex in the response of plasma free fatty acids, cholesterol and phospholipids to epinephrine injection. J Clin Invest 39: 210–219Google Scholar
  123. Shafrir E, Sussman EK, Steinberg D (1960) Role of the pituitary and the adrenals in the mobilization of free fatty acids and lipoproteins. J Lipid Res 1: 459–465PubMedGoogle Scholar
  124. Shaw JE, Ramwell PW (1968) Release of prostaglandin from rat epididymal fat pad on nervous and hormonal stimulation. J Biol Chem 243: 1498–1503PubMedGoogle Scholar
  125. Shechter Y (1982) Evaluation of adenosine or related nucleosides as physiological regulators of lipolysis in adipose tissue. Endocrinology 110: 1579–1583PubMedGoogle Scholar
  126. Steinberg D, Huttunen JK (1972) The role of cyclic AMP in activation of hormone-sensitive lipase of adipose tissue. Adv Cyclic Nucleotide Res 1: 47–62PubMedGoogle Scholar
  127. Steinberg DM, Shafrir E, Vaughan M (1969) Direct effect of glucagon on release of unesterified fatty acids (UFA) from adipose tissue. Clin Res 7: 250Google Scholar
  128. Steinberg D, Vaughan M, Nestel PJ, Bergström S (1963) Effects of prostaglandin E opposing those of catecholamine on blood pressure and on triglyceride breakdown in adipose tissue. Biochem Pharmacol 12: 764–766Google Scholar
  129. Stone DB, Brown JD, Steele AA (1969) Effect of sodium salicylate on induced lipolysis in isolated fat cells of the rat. Metabolism 18: 620–624PubMedGoogle Scholar
  130. Strosser MT, Cohen L, Koch B, Miahle P (1981) La somatostatine: une hormone pancréatique qui pourrait être importante. Journ Annu Diabetol Hôtel Dieu 197–210Google Scholar
  131. Unger RH (1981) The milieu interieur and the islets of Langerhans (Claude Bernard Memorial Lecture). Diabetologia 20: 1–12PubMedGoogle Scholar
  132. Unger RH, Eisentraut AM (1964) Studies of the physiological role of glucagon. Diabetes 13: 563–568PubMedGoogle Scholar
  133. Valverde I, Rigopoulou D, Exton J, Ohneda A, Eisentraut AM, Unger RH (1968) Demonstration and characterization of a second fraction of glucagon-like immunoreactivity in jejunal extracts. Am J Med Sci 255: 415–420PubMedGoogle Scholar
  134. Vaughan M (1960) Effect of hormones on phosphorylase activity in adipose tissue. J Biol Chem 235: 3049–3053PubMedGoogle Scholar
  135. Vaughan M, Steinberg D (1963) Effect of hormones on lipolysis and esterification of free fatty acids during incubation of adipose tissue in vitro. J Lipid Res 4: 193–199PubMedGoogle Scholar
  136. Vizek K, Razova M, Melichar V (1979) Lipolytic effect of TSH, glucagon and hydrocortisone on the adipose tissue of new borns and adults in vitro. Physiol Bohemoslov 28: 325–331PubMedGoogle Scholar
  137. Weinges KF (1961) The effect of glucagon and insulin on the metabolism of non-esterified fatty acids in isolated fatty tissue of the rat in vitro. Klin Wochenschr 39: 293–298PubMedGoogle Scholar
  138. Weinges KF (1968) Glucagon. Thieme, StuttgartGoogle Scholar
  139. Whitty A J, Shima K, Trubow M, Foà PP (1967) Effect of glucagon on serum FFA in normal and depancreatized dogs. Fed Proc 26: 15Google Scholar
  140. Whitty A J, Shima K, Trubow M, Foà PP (1969) Effect of glucagon and of insulin of serum free fatty acids in normal and depancreatized dogs. Proc Soc Exp Biol Med 130: 55–61PubMedGoogle Scholar
  141. Wieland O, Suyter M (1957) Glycerokinase: its isolation and properties. Biochem Z 329: 320–331PubMedGoogle Scholar
  142. Wörner H, Weinges KF (1961) Über den Einfluß von Insulin und Glukagon auf den Glukosestoffwechsel des epididymalen Fettanhanges der Ratte in vitro. Der Einfluß von Glukagon im Vergleich mit dem Insulineffekt. Klin Wochenschr 39: 243–246Google Scholar
  143. Zumstein P, Zapf J, Froesch ER (1974) Effects of hormones on cyclic AMP release from rat adipose tissue in vitro. FEBS Lett 41: 65–69Google Scholar

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  • P. J. Lefebvre

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