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Glucagon and Liver Glycogen Metabolism

  • Chapter
Glucagon I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 1))

Abstract

The stimulatory effect of glucagon on the conversion of liver glycogen to blood glucose was the first documented property of glucagon, the “hyperglycemic glycogenolytic factor” discovered as a contaminant in some commercial preparations of insulin. Sutherland (1950) has reviewed the early evidence that indicated the hormonal nature of glucagon, distinct from insulin, and that established the liver as the target for the hormone’s action. By the analysis of serial blood and liver samples from anesthetized dogs, Cahill et al. (1957) were able to link directly the glucagon-induced hyperglycemia with hepatic glycogenolysis. The effects of glucagon to increase both glucose output and glycogen breakdown in various isolated liver preparations may be well known; as experimental sophistication has grown over the years, such effects have been demonstrated in rabbit liver slices (Sutherland 1950), isolated perfused rat liver (SOKAL et al. 1964), isolated hepatocytes (Garrison and Haynes 1973; Seglen 1973; Wagle and Ingebretsen 1973), and liver cells in primary culture (Gerschenson and Casanello 1968; Walker and Grindle 1977). Numerous reports have stated similar observations, usually with liver preparations from rats or rabbits, but occasionally also from mice (Assimaco-poulos-Jeannet et al. 1973; Müller et al. 1976).

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  1. W. Stalmans
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Editors and Affiliations

  1. University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Mèdecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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© 1983 Springer-Verlag Berlin Heidelberg

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Stalmans, W. (1983). Glucagon and Liver Glycogen Metabolism. In: Lefèbvre, P.J. (eds) Glucagon I. Handbook of Experimental Pharmacology, vol 66 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68866-9_14

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  • DOI: https://doi.org/10.1007/978-3-642-68866-9_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68868-3

  • Online ISBN: 978-3-642-68866-9

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