Glucagon I pp 223-244 | Cite as

Heterogeneity of Circulating Glucagon and Glucagon-Like Immunoreactivity

  • I. Valverde
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 66 / 1)


Multiple molecular forms of immunoreactive glucagon and glucagon-like immunoreactants have been described in various tissues and in the circulation. Some of these forms, as in the case of many other polypeptide hormones, may be related to glucagon biosynthesis (see Chaps. 6 and 7). At present, it is not clearly established whether the glucagon heterogeneity found in plasma is merely a reflection of that found in pancreatic or extrapancreatic tissues. The heterogeneity of circulating glucagon has been demonstrated by means of plasma gel filtration and subsequent glucagon radioimmunoassay of the eluates with different antisera.


Plasma Glucagon Pancreatic Glucagon Immunoreactive Glucagon Oral Glucose Administration Pancreatectomized Patient 
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© Springer-Verlag Berlin Heidelberg 1983

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  • I. Valverde

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