Skip to main content

Regulation der Genexpression bei Eukaryonten

  • Chapter
Genetik
  • 173 Accesses

Zusammenfassung

Wir wissen viel über die Regulation der Genexpression bei Prokaryonten, aber relativ wenig darüber bei Eukaryonten. Wie wir sehen werden, ist das Operonsystem der Genregulation bei Eukaryonten nicht anwendbar. Eukaryonten sind bezüglich der Organisation ihrer Zellen komplexer gebaut als Prokaryonten. Ihre Zellen sind durch viele Membransysteme in Kompartimente unterteilt. Von besonderem Interesse ist der Zellkern, der die Hauptmasse des genetischen Materials enthält. Diese Kompartimentierung hat Folgen für die Regulation der Genexpression. Wir wollen im folgenden die Wirkorte zusammenfassen, an denen Regulation eingreifen kann oder könnte, um die Enzymsynthese in tierischen Zellen zu kontrollieren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

ÜBersichtsartikeL Zu Kapitel

Literatur

  • Britten RJ, Davidson EH (1969) Gene regulation for higher cells: a theory. Science 165:349–357

    Article  PubMed  CAS  Google Scholar 

  • Brown DD, Dawid IB (1968) Specific gene amplification in oocytes. Science 160:272–280

    Article  PubMed  CAS  Google Scholar 

  • Brown DD, Dawid IB (1969) Developmental genetics. Annu Rev Genet 3:127–154

    Article  CAS  Google Scholar 

  • Burgoyne L, Case ME, Giles NH (1969) Purification and properties of the aromatic (arom) synthetic enzyme aggregate of Neurospora crassa. Biochim Biophys Acta 19:452–462

    Google Scholar 

  • Calvo JM, Fink GR (1971) Regulation of biosyn thetic pathways in bacteria and fungi. Annu Rev Biochem 40:943–968

    Article  CAS  Google Scholar 

  • Case ME, Giles NH (1971) Partial enzyme aggregates frmed by pleiotropic mutants in the arom gene Cluster of Neurospora crassa. Proc Natl Acad Sci USA 68:58–62

    Article  PubMed  CAS  Google Scholar 

  • Case ME, Giles NH (1975) Genetic evidence on the Organisation and action of the qa-1 gene produet: a protein regulating the induction of three enzymes in quinate metabolism in Neurospora crassa. Proc Natl Acad Sci USA 72:553–557

    Article  PubMed  CAS  Google Scholar 

  • Case ME, Giles NH (1976) Gene order in the qa gene Cluster of Neurospora crassa. Mol Gen Genet 147:83–89

    Article  PubMed  CAS  Google Scholar 

  • Clever U (1968) Regulation of chromosome function. Annu Rev Genet 2:11–30

    CAS  Google Scholar 

  • Davidson EH (1968) Gene activity in early development. Academic Press, New York

    Google Scholar 

  • Davidson EH, Britten RJ (1973) Organization, transcription and regulation in the animal genome. Quart Rev Biol 48:565–613

    Article  PubMed  CAS  Google Scholar 

  • Davidson EH, Britten RJ (1979) Regulation of gene expression: possible roles of repetitive sequences. Science 204:1052–1059

    Article  PubMed  CAS  Google Scholar 

  • Douglas HC, Howthorne DC (1966) Regulation of genes Controlling synthesis of the galactose pathway enzymes in yeast. Genetics 54:911–916

    PubMed  CAS  Google Scholar 

  • Douglas HC, Hawthorne DC (1972) Uninducible mutants in the gal i locus of Saccharomyces cerevisiae. J Bacteriol 109:1139–1143

    PubMed  CAS  Google Scholar 

  • Giles NH, Case ME, Partridge CWH, Ahmed SI (1967) A gene Cluster in Neurospora crassa coding for an aggregate of flve aromatic synthetic enzymes. Proc Natl Acad Sci USA 58:1453–1460

    Article  PubMed  CAS  Google Scholar 

  • Gurdon JB (1968) Transplanted nuclei and cell differentiation. Sci Am 219:24–35

    Article  PubMed  CAS  Google Scholar 

  • Gurdon JB (1974) The control of gene expression in animal development. Harvard University Press, Cambridge, MA

    Google Scholar 

  • Hautala JA, Jacobson JW, Case ME, Giles NH (1975) Purification and characterization of catabolic dehydroquinase, an enzyme in the inducible quinic acid catabolic pathway of Neurospora crassa. J Biol Chem 250:6008–6014

    PubMed  CAS  Google Scholar 

  • Jacobson JW, Hautala JA, Case ME, Giles NH (1975) Effect of mutations in the qa gene Cluster of Neurospora crassa on the enzyme catabolic dehydroquinase. J Bacteriol 124:491–496

    PubMed  CAS  Google Scholar 

  • Lodish HF (1976) Translational control of protein synthesis. Annu RevBiochem 45:39–72

    Article  CAS  Google Scholar 

  • Matsumoto K, Toh-E A, Ushima Y (1978) Genetic control of galactokinase synthesis in Saccharomyces cerevisiae evidence for constitutive expression of the positive regulatory gene gal 4. J Bacteriol 134:446–457

    PubMed  CAS  Google Scholar 

  • Metzenberg RL (1972) Genetic regulatory Systems in Neurospora. Annu Rev Genet 6:111–132

    Article  PubMed  CAS  Google Scholar 

  • O’Malley BW, Towle HC, Schwartz RJ (1977) Regulation of gene expression in eukaryotes. Annu Rev Genet 11:239–275

    Article  PubMed  Google Scholar 

  • Pitot HC, Yatvin MB (1973) Interrelationships of mammalian hormones and enzyme levels in vitro. Physiol Rev 53:228–325

    PubMed  CAS  Google Scholar 

  • Revel M, Groner Y (1978) Post-transcriptional and translational controls of gene expression in eukaryotes. Annu Rev Biochem 47:1079–1126

    Article  PubMed  CAS  Google Scholar 

  • Stein GS, Speisberg TC, Kleinsmith LJ (1974) Nonhistone chromosomal proteins and gene regulation. Science 183:817–824

    Article  PubMed  CAS  Google Scholar 

  • Tomkins GM, Martin DW (1970) Hormones and gene expression. Annu Rev Genet 4:91–106

    Article  PubMed  CAS  Google Scholar 

  • Walker PR (1977) Regulation of enzyme synthesis in animal cells. Essays Biochem 13:39–69

    PubMed  CAS  Google Scholar 

  • Yamamoto KR, Alberts BM (1976) Steroid rceeptors: elements for modulation of eukaryotic transcription. Annu Rev Biochem 45: 721–746

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Russell, P.J. (1983). Regulation der Genexpression bei Eukaryonten. In: Genetik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68865-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68865-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12063-6

  • Online ISBN: 978-3-642-68865-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics