Abstract
The development of hybridoma and monoclonal antibody technology by Köhler and Milstein in 1975 [1] was certainly a major scientific event, without which the current workshop would not be held. Great expectations were clearly aroused in the immunologic and hematologic communities as a result of this technology. Specifically, the high expectations were related to the use of these antibodies in several areas, three of which we will discuss. In this report we hope to briefly review progress in the areas of (a) lineage-specific differentiation antigens, (b) leukemia-specific antigens, and (c) therapeutic use of monoclonal antibodies. Since the organizers of this meeting have requested that this be in the form of an editorial, we will attempt to conform.
Supported in part by grants from the National Cancer Institute (CA 25097, CA 21737, and CA 31685)
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References
Köhler G, Milstein G (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 495–497
Carroll L (1960) The annotated Alice. Bramhall, New York p 264
Abramson C, Kersey J, LeBien T (1981) A monoclonal antibody (BA-1) primarily reactive with cells of human B lymphocyte lineage. J Immunol 126: 83–88
Platt JL, LeBien TW, Michael AF (1983) Stages of renal ontogenesis identified by monoclonal antibodies reactive with lymphohemopoietic differentiation antigens. J Exp Med (in press)
Stashenko P, Nadler LM, Hardy R, Schlossman SF (1980) Characterization of a human B lymphocyte specific antigen. J Immunol 125: 1678–1685
Brooks PA, Beckman I, Bradley J, McNamara PJ, Thomas ME, Zola H (1980) Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. I. A hybridoma secreting antibody against a marker specific for human B lymphocytes. Clin Exp Immunol 39: 477–485
Kersey JH, LeBien TW, Abramson CS, Newman R, Sutherland R, Greaves M (1981) p24: A human hemopoietic progenitor and acute lymphoblastic leukemia-associated cell surface structure identified with monoclonal antibody. J Exp Med 153: 726–731
Melink GB, LeBien TW (to be published) Construction of an antigenic map for human B cell precursors. J Clin Immunol
Neudorf SML, Boue DR, LeBien TW, Kersey JH (to be published) The common acute lymphoblastic leukemia antigen may define recent migrants to the human thymus. Exp. Hematol
Jones NH, Borowitz MJ, Metzgar RS (1982) Characterization and distribution of a 24000-dalton antigen defined by a monoclonal antibody (DU-ALL-1) elicited to common acute lymphoblastic leukemia (cALL) cells. Leuk Res 2: 449–464
Newman RA, Sutherland DR, LeBien TW, Kersey JH, Greaves MF (1982) Biochemical characterization of leukemia associated antigen p24 defined by the monoclonal antibody BA-2. Biochim Biophys Acta 701: 318–327
Hercend T, Nadler LM, Pesando JM, Reinherz EL, Schlossman SF, Ritz J (1981) Expression of a 26000-dalton glycoprotein on activited human T cells. Cell Immunol 64: 192–196
Brooks DA, Bradley J, Zola H (1982) A differentiation antigen expressed selectively by a proportion of human blood cells: Detection with a monoclonal antibody. Pathology 14: 5–11
Greaves M, Delia D, Janossy G, Rapson N, Chessels J, Woods M, Prentice G (1980) Acute lymphoblastic leukemia associated antigen. IV. Expression on non-leukemic lymphoid cells. Leuk Res 4: 15–32
Metzgar RS, Borowitz MJ, Jones NH, Dowell BL (1981) Distribution of common acute lymphoblastic leukemia antigen in nonhematopoietic tissues. J Exp Med 154: 1249–1254
Lane DL, Koprowski H (1982) Molecular recognition and the future of monoclonal antibodies. Nature 296: 200–202
Ritz J, Schlossman SF (1982) Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood 59: 1–11
Filipovich AH, MGeave P, Ramsay NKC, Goldstein G, Mersey JH (1982) Pretreatment of donor bone marrow with monoclonal antibodies for prevention of acute graft versus host disease in allogeneic histocompatible bone marrow transplantation. Lancet 1: 1266–1269
Le Bien TW, Ash RC, Zanjani ED, Kersey JH (to be published) In vitro cytodestruction of leukemia cells in human bone marrow using a cocktail of monoclonal antibodies. In: Neth VR (ed) Modern trends in human leukemia.
Kaizer H, Levy R, Santos GW (1982) Autologous bone marrow transplantation in T-cell malignancies: Use of in vitro monoclonal antibody treatment of remission marrow to eliminate tumor cells. J Cell Biochem [Supp] 6: 41
Ritz J, Sallan S, Bast RC, Liptin JM, Clavell LA, Feeney M, Hercend T, Nathan DG, Schloss-man SF (1982) Autologous bone marrow transplantation in CALLA positive acute lymphoblastic leukemia after in vitro treatment with J5 monoclonal antibody and complement. Lancet 2: 60–63
LeBien T, Kersey J (1980) A monoclonal antibody (TA-1) reactive with human T lymphocytes and monocytes. J Immunol 125: 2208–2214
LeBien TW, Boue DR, Bradley JG, Kersey JH (1982) Antibody affinity may influence antigenic modulation of the common acute lymphoblastic leukemia antigen in vitro. J Immunol 129: 2287–2292
Tatsumi E, Sugimoto T, Minato K, Sagawa K, Civen C, Early A, Preisler H, Henderson E, Minowada J (1982) Heterogeneity of AML and CML blasts as determined by multiple monoclonal antibodies. Proc Am Soc Cl in Oncol
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Kersey, J.H., LeBien, T.W. (1984). What Happened to Lineage-and Leukemia-Specific Antigens? Implications for Therapeutic Use of Monoclonal Antibodies. In: Bernard, A., Boumsell, L., Dausset, J., Milstein, C., Schlossman, S.F. (eds) Leucocyte Typing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68857-7_70
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DOI: https://doi.org/10.1007/978-3-642-68857-7_70
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