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Transitional Pre-B to B Acute Lymphoblastic Leukemia

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Leucocyte Typing

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Abstract

Approximately 20% of patients with acute lymphoblastic leukemia (ALL) present features of pre-B cells, i. e., small quantities of p, heavy chains in their cytoplasm and no detectable surface immunoglobulin [1, 2]. In individual patients, however, a subpopulation of cells bearing scant amounts of surface p. without detectable intracytoplasmic or surface light chains has been observed. This phenotype is thought to represent cells at a transitional pre-B/B cell stage of development, based on immunoglobulin expression [3, 4, 5]. Therefore, cellular phenotypes within pre-B ALL clones are variable in individual patients at diagnosis, may alter or shift in relapse (variable “window” of maturation arrest) as well as show some “asynchrony” of gene expression, but retain overall lineage fidelity [6]. We report a very poor prognosis for a case of ALL in a 13-month-old female child with the phenotype of transitional pre-B/B lymphocytes, who relapsed early in treatment and retained the same major position and stringency of maturation arrest.

Supported by CNR Grant No.82.00373.96 PFCCN, Rome

The authors are indebted to Dr. Marina Marini, Institute of Histology, University of Bologna for the TdT biochemical assay

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Authors
  1. P. Paolucci
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  2. V. Vecchi
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  3. P. Rosito
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  4. L. Serra
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  5. M. Gobbi
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  6. G. Paolucci
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Editor information

Editors and Affiliations

  1. Institut Gustave Roussi, Service de Pédiatrie, Rue Camille Dismoulins, F-94800, Villejuif, France

    Alain Bernard

  2. INSERM U. 93, Hôpital Saint-Louis, F-75475, Paris Cedex 10, France

    Laurence Boumsell

  3. Institut de Recherches sur les Maladies du Sang, Hôpital Laint-Louis, F-75475, Paris Cedex 10, France

    Jean Dausset

  4. MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, Great Britain

    César Milstein

  5. Sidney Farber Cancer Institute, 44 Binney Street, 02115, Boston, MA, USA

    Stuart F. Schlossman

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© 1984 Springer-Verlag Berlin Heidelberg

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Paolucci, P., Vecchi, V., Rosito, P., Serra, L., Gobbi, M., Paolucci, G. (1984). Transitional Pre-B to B Acute Lymphoblastic Leukemia. In: Bernard, A., Boumsell, L., Dausset, J., Milstein, C., Schlossman, S.F. (eds) Leucocyte Typing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68857-7_64

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  • DOI: https://doi.org/10.1007/978-3-642-68857-7_64

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68859-1

  • Online ISBN: 978-3-642-68857-7

  • eBook Packages: Springer Book Archive

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