Differences in Antigen Expression on Normal Thymocytes and on Cells Derived from Hyperplastic Thymi and Thymoma of Myasthenia Gravis Patients

  • I. Doxiadis
  • H. Grosse-Wilde
  • R. Hohlfeld
  • K. V. Toyka


Myasthenia gravis (MG) is a neuromuscular disorder characterized by weakness and fatigability of muscles. It is now established that patients suffering from MG have a decreased number of acetylcholine receptors (AChR) at their neuromuscular junctions [1–6].


Acetylcholine Receptor Normal Thymus Acetylcholine Receptor Antibody Peripheral Blood Lympho Scripps Clinic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Simpson JA (1960) Myasthenia gravis. A new hypothesis. Scott Med J 5: 419–436Google Scholar
  2. 2.
    Farnbrough DM, Drachman DB, Satyamurti S (1973) Neuromuscular junction in myasthenia gravis: dicreased acetylcholine receptors. Science 182: 293–295CrossRefGoogle Scholar
  3. 3.
    Almon RR, Andrews CG, Appel SH (1974) Serum globin in myasthenia gravis: inhibition of alpha-bungarotoxin binding to acetylcholine receptors. Science 186: 55–57PubMedCrossRefGoogle Scholar
  4. 4.
    Almon RR, Appel SH (1975) Interaction of myasthenic serum globin with the acetylcholine receptor. Biochem Biophys Acta 393: 66–77PubMedCrossRefGoogle Scholar
  5. 5.
    Bender AN, Ringel SD, Engel WK, Daniels MP, Vogel Z (1975) Myasthenia gravis: a serum factor blocking acetylcholine receptor of the human neuromuscular junction. Lancet I: 607–609Google Scholar
  6. 6.
    Patrick J, Lindstrom JM (1973) Autoimmune response to acetylcholine receptor. Science 180: 871–872PubMedCrossRefGoogle Scholar
  7. 7.
    Toyka KV, Drachman DB, Griffin DE, Pestronk A, Winkelstein JA, Fischbeck KH, Kao I (1977) Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice. N Engl J Med 296: 125–131Google Scholar
  8. 8.
    Keésey J, Lindstrom J, Gokely H, Heimann C (1977) Anti acetylcholine receptor antibody in neonatal myasthenia gravis. N Engl J Med 296: 55–58PubMedGoogle Scholar
  9. 9.
    Grosse-Wilde H, Toyka KV, Besinger UA, Doxiadis I, Heininger K, Hömberg M, Hömberg V, Hohlfeld R, Fateh-Moghadam A, Jungwirth I, Kreeb G, Vögeler U (1982) Zur Immungenetik der Myasthenia Gravis: Bedeutung der HLA-, Komplement-und Gm-Gensysteme für klinische und immunologische Parameter. Dtsch Med Wochenschr (in press)Google Scholar
  10. 10.
    Zilko Pi, Dawkins RL, Holmes K, Will C (1979) Genetic control of suppressor lymphocyte function in myasthenia gravis: relationship of impaired suppressor function to HLA-B 8/Drw 3 and cold reactive lymphocytotoxic antibodies. Clin Immunol Immunopathol 14: 222–230CrossRefGoogle Scholar
  11. 11.
    Sorensen SF, Andersen V, Bendtzen K, Fulpius BW, Krarum C, Monnier VM, Permin H, Platz P, Soeberg B, Thomsen M (1978) Immunological studies in thymectomised and non-thymectomised patients with myasthenia gravis. J Clin Lab Immunol 1: 169–178PubMedGoogle Scholar
  12. 12.
    Piantelli M, Lauriola L, Carbone A, Evoli A, Tonali P, Musiani PB (1979) Subpopulations of T-lymphocytes in myasthenia gravis patients. Clin Exp Immunol 36: 85–89PubMedGoogle Scholar
  13. 13.
    Lisak RP, Smiley R, Schotland DH, Bank WJ, Santoli D (1979) Abnormalities of T-cell subpopulations in the blood and thymus of patients with myasthenia gravis. J Neurol Sci 44: 69–76PubMedCrossRefGoogle Scholar
  14. 14.
    Shore A, Limatibul S, Dosch HM, Gelfund EW (1979) Identification of two serum components regulating the expression of T-lymphocyte function in childhood myasthenia gravis. N Engl J Med 301: 625–629PubMedCrossRefGoogle Scholar
  15. 15.
    Reinherz EL, Moretta L, Roper M, Breard JM, Mingani MC, Cooper MD, Schlossmann SJ (1980) Human T-lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. J Exp Med 151: 967–974CrossRefGoogle Scholar
  16. 16.
    Abdou NI, Lisak RP, Zweiman B, Abrahamsohn I, Penn AS (1974) The thymus in myasthenia gravis. Evidence for altered cell populations. N Engl J Med 291: 1271–1275Google Scholar
  17. 17.
    Goldstein G, Hoffman WW (1968) Electrophysiological changes similar to those of myasthenia gravis in rats with experimental autoimmune thymitis. J Neurol Neurosurg Psychiatry 31: 453–459PubMedCrossRefGoogle Scholar
  18. 18.
    Twomey JJ, Lewis VM, Patten BM, Goldstein G, Good RA (1979) Myasthenia gravis, thymectomy and serum hormone activity. Am J Med 66: 639–644PubMedCrossRefGoogle Scholar
  19. 19.
    Newson-Davis J, Willcox N, Calder L (1981) Thymus cells in myasthenia gravis selectively enhance production of anti-acetylcholine receptor antibody by autologous blood lymphocytes. N Engl J Med 305: 1313–1318CrossRefGoogle Scholar
  20. 20.
    Vincent A, Scadding GK, Thomas HC, Newson-Davis J (1978) In vitro synthesis of anti-acetylcholine receptor antibody by thymic lymphocytes in myasthenia gravis. Lancet I: 305–307Google Scholar
  21. 21.
    Scadding GK, Vincent A, Newson-Davis J, Henry K (1981) Acetylcholine receptor antibody synthesis by thymic lymphocytes in vitro. Neurology 31: 935–943PubMedCrossRefGoogle Scholar
  22. 22.
    Wekerle H, Ketelsen UP, Zurn HD, Fulpius BW (1978) Intrathymic pathogenesis of myasthenia gravis: transient expression of acetylcholine receptors on thymus-derived myogenic cells. Eur J Immunol 8: 579–582PubMedCrossRefGoogle Scholar
  23. 23.
    Castleman B, Norris EH (1949) The pathology of the thymus in myasthenia gravis: a study of 35 cases. Medicine 28: 27–58PubMedGoogle Scholar
  24. 24.
    Simpson JA (1958) An evaluation of thymectomy in myasthenia gravis. Brain 81: 112–144PubMedCrossRefGoogle Scholar
  25. 25.
    Namba T, Brunner NG, Grob D (1958) Myasthenia gravis in patients with thymoma with particular reference to onset after thymectomy. Medicine 57: 411–433Google Scholar
  26. 26.
    Compston DAS, Vincent A, Newson-Davis J, Batchelor JR (1980) Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 103: 579–601Google Scholar
  27. 27.
    Vincent A (1981) Immunology of myasthenia gravis: recent developments. Clin Immunol Allergy 1: 161–179Google Scholar
  28. 28.
    Genkins G, Papatestas AE, Horowitz SH and Kornfeld P (1975) Studies in myasthenia gravis: early thymectomy. Am J Med 58: 517–524PubMedCrossRefGoogle Scholar
  29. 29.
    Werner C, Klouda PT, Correa MC, Vassalli P, Jeannet K (1977) Isolation of B and T lymphocytes by mylon fiber columns. Tissue Antigens 9: 227–229PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • I. Doxiadis
  • H. Grosse-Wilde
  • R. Hohlfeld
  • K. V. Toyka

There are no affiliations available

Personalised recommendations