On the Bone Marrow Origin of the Human Mast Cell: In Vitro Growth and Characterization of Human Malignant Mast Cells
It is some 100 years since the mast cell (MC) was described by Paul Ehrlich. Since then, the MC has become recognised as a fundamental component of the immediate hypersensitivity reaction; it probably plays an important role in a variety of other pathological processes as well . Intriguingly, it is also possible that MCs share a developmental origin and some functions with the natural killer cell [2, 6] and thus may be involved in a wider range of immunological reactions than was previously considered. Yet many aspects of MC biology remain unclear.
KeywordsPeroxi Leukemia Dimethyl Histamine Sulfoxide
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- 1.Dy M, Guy-Grand D, Nabarra B (1981) Secondary MLC supernatants induce proliferation of “mast-like” cells from normal bone marrow cells. In: Resch K, Kirchner H (eds) Mechanism of lymphocyte activation. Elsevier/North Holland, Amsterdam p 554Google Scholar
- 8.Metcalf DD, Kaliner M, Donlon MA (1981) The mast cell. CRC Crit Rev Immunol 3: 23Google Scholar
- 13.Selye H (1965) The mast cell. Butterworths, WashingtonGoogle Scholar