On the Bone Marrow Origin of the Human Mast Cell: In Vitro Growth and Characterization of Human Malignant Mast Cells
It is some 100 years since the mast cell (MC) was described by Paul Ehrlich. Since then, the MC has become recognised as a fundamental component of the immediate hypersensitivity reaction; it probably plays an important role in a variety of other pathological processes as well . Intriguingly, it is also possible that MCs share a developmental origin and some functions with the natural killer cell [2, 6] and thus may be involved in a wider range of immunological reactions than was previously considered. Yet many aspects of MC biology remain unclear.
KeywordsMast Cell Systemic Mastocytosis Human Promyelocytic Leukemia Cell Human Myeloid Leukemia Cell Bone Marrow Origin
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