Abstract
B lymphocytes derive from bone marrow pluripotent stem cells and mature through a number of discernible stages. Antigen stimulates B cells to differentiate either into memory cells or into antibody-producing plasma cells. Distinct stages of B cell maturation can be recognised by the expression of immunoglobulin (Ig), which is the characteristic functional product of B lymphocytes. However, studies of B cell maturation and differentiation based solely on Ig expression lack detail, and additional markers are needed to allow a clearer understanding of the entire B cell lineage.
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Zola, H. et al. (1984). The Human B Cell Lineage Studied with Monoclonal Antibodies. In: Bernard, A., Boumsell, L., Dausset, J., Milstein, C., Schlossman, S.F. (eds) Leucocyte Typing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68857-7_26
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DOI: https://doi.org/10.1007/978-3-642-68857-7_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68859-1
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