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Human B Cell-Associated Antigens: Expression on Normal and Malignant B Lymphocytes

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Leucocyte Typing

Abstract

Human B lymphocyte ontogeny and differentiation has been traditionally studied by the sequential expression of a series of B cell markers including heavy chain isotypes of immunoglobulin [1, 2], HLA-D-related Ia-like antigens [3–5], receptors for complement components [6, 7] and for the Fc portion of immunoglobulin [8, 9], and receptors for murine and monkey erythrocytes [10, 11]. Although these markers have provided insight into the stages of normal B cell differentiation, their utility has been limited because they are also expressed on cells of other lineages. The development of monoclonal antibodies which identify unique B cell-associated antigens has already begun to provide a series of new reagents to more precisely study the sequence of normal human B cell differentiation.

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Authors
  1. L. M. Nadler
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  2. K. C. Anderson
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  3. M. Bates
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  4. E. Park
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  5. B. Slaughenhoupt
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  6. S. F. Schlossman
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Editor information

Editors and Affiliations

  1. Institut Gustave Roussi, Service de Pédiatrie, Rue Camille Dismoulins, F-94800, Villejuif, France

    Alain Bernard

  2. INSERM U. 93, Hôpital Saint-Louis, F-75475, Paris Cedex 10, France

    Laurence Boumsell

  3. Institut de Recherches sur les Maladies du Sang, Hôpital Laint-Louis, F-75475, Paris Cedex 10, France

    Jean Dausset

  4. MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, Great Britain

    César Milstein

  5. Sidney Farber Cancer Institute, 44 Binney Street, 02115, Boston, MA, USA

    Stuart F. Schlossman

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© 1984 Springer-Verlag Berlin Heidelberg

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Nadler, L.M., Anderson, K.C., Bates, M., Park, E., Slaughenhoupt, B., Schlossman, S.F. (1984). Human B Cell-Associated Antigens: Expression on Normal and Malignant B Lymphocytes. In: Bernard, A., Boumsell, L., Dausset, J., Milstein, C., Schlossman, S.F. (eds) Leucocyte Typing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68857-7_25

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  • DOI: https://doi.org/10.1007/978-3-642-68857-7_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68859-1

  • Online ISBN: 978-3-642-68857-7

  • eBook Packages: Springer Book Archive

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