Abstract
The human immune response is regulated by interactions among T lymphocyte subpopulation which are functionally and antigenically distinct. The identification and functional characterization of these subsets has been greatly facilitated by the availability of monoclonal antibodies reactive with various T cell membrane antigens. Hence, helper T cells express membrane antigens recognized by the monoclonal antibodies OKT4 and Leu 3, while T lymphocytes reactive with the OKT8 and Leu 2 antibodies have cytotoxic and suppressor cell activity [1–3]. Additional understanding of the functional heterogeneity of immunoregulatory T cell subsets has been achieved in studies investigating the coexpression of markers recognized by various monoclonal antibodies [4, 5].
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References
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© 1984 Springer-Verlag Berlin Heidelberg
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Clement, L.T., Landay, A. (1984). Identification and Characterization of a Suppressor T Cell Subpopulation with Monoclonal Antibodies. In: Bernard, A., Boumsell, L., Dausset, J., Milstein, C., Schlossman, S.F. (eds) Leucocyte Typing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68857-7_20
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DOI: https://doi.org/10.1007/978-3-642-68857-7_20
Publisher Name: Springer, Berlin, Heidelberg
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