The Human Epsilon Globin Gene — A Paradigm for Erythroid Differentiation

  • J. Paul
  • M. Allan
  • J. Grindlay
  • D. Spandidos
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 25.–27. März 1982 in Mosbach/Baden book series (MOSBACH, volume 33)


The fundamental unsolved problem of cell differentiation is how a common genome can be used to give a wide spectrum of cell types. Accumulated information has clearly shown that no simple mechanism is responsible. In individual cases differences in expression of a gene have been found to be due to gene loss, gene amplification, transposition of DNA, modification of DNA, transcription, processing, transport and stability of RNA or translation, modification or turnover of protein. It is not difficult to understand why teleological arguments, though not scientifically respectable, have an appeal because it would almost seem that a cell will exploit any available mechanism to achieve the best levels of expression of individual genes to meet the demands of the environment. In searching for some order in this process theories have varied from those which ascribe a predominant role to transcriptional control [1] to those like the cascade hypothesis [2] which envisage controls at all possible stages of expression.


K562 Cell Thymidine Kinase Globin Gene Erythroid Cell Erythroid Differentiation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • J. Paul
  • M. Allan
  • J. Grindlay
  • D. Spandidos
    • 1
  1. 1.Garscube EstateThe Beatson Institute for Cancer ResearchBearsden, GlasgowGreat Britain

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