The Human Epsilon Globin Gene — A Paradigm for Erythroid Differentiation
The fundamental unsolved problem of cell differentiation is how a common genome can be used to give a wide spectrum of cell types. Accumulated information has clearly shown that no simple mechanism is responsible. In individual cases differences in expression of a gene have been found to be due to gene loss, gene amplification, transposition of DNA, modification of DNA, transcription, processing, transport and stability of RNA or translation, modification or turnover of protein. It is not difficult to understand why teleological arguments, though not scientifically respectable, have an appeal because it would almost seem that a cell will exploit any available mechanism to achieve the best levels of expression of individual genes to meet the demands of the environment. In searching for some order in this process theories have varied from those which ascribe a predominant role to transcriptional control  to those like the cascade hypothesis  which envisage controls at all possible stages of expression.
KeywordsK562 Cell Thymidine Kinase Globin Gene Erythroid Cell Erythroid Differentiation
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