Inhibition of the Induction of Contrasuppression by Antisera Against Tumor-Associated Surface Antigens on Methylcholanthrene-induced Sarcomas
Contrasuppression is an immunoregulatory T-cell activity that protects Lyt 1+, 2– T-helper cell activity from suppression. This activity involves both an “induction” (afferent) phase, which requires the activation of an Lyt 1+, 2– effector T cell by cells in the contrasuppressor circuit , and an “effector” (efferent) phase, in which the effector cells or cell-free products secreted by these cells render TH cells resistant to suppression . Recently we discovered an activity in antisera raised against methylcholanthrene-induced sarcomas from Balb/c mice, which blocks T-cell regulatory activity . These antisera block the afferent as well as the efferent phase of suppression to SRBC in vitro, but only in animals which express the same Igh gene polymorphism as Balb/c (Igha). We therefore tested whether these antisera could block the afferent and efferent phases of contrasuppression, and whether this activity had any effect on the growth of tumors in those mice.
KeywordsLeukemia Sarcoma Sorb Sera
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