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Structural and Functional Aspects of the T-Cell Differentiation Antigens T3, T6, and T8

  • C. Terhorst
  • J. Borst
  • P. Lerch
  • M. van de Rijn
  • P. Snow
  • H. Spits
  • J. de Vries
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)

Abstract

The progressive diversification of T-lymphocytes begins within the thymus gland. Since cell-cell interactions may play a major role in this process, the study of the expression of thymic surface markers would aid our understanding of thymic differentiation. On murine thymocytes, selective expression of genes coding for cell surface markers has been studied with alloantisera [l]. More recently, monoclonal antibodies have made possible the study of selective expression of cell surface glycoproteins on human thymocytes. Thus, as in the mouse, early and late events in the thymic differentiation have been recognized [2]. Although the precise function of these thymic differentiation antigens remains to be determined, it seems plausible that they may govern associative recognition among cooperative cells sets. One could therefore surmise that inappropriate expression of some of the thymic differentiation antigens may playa role in leukemogensis.

Keywords

Trypsin Treatment Associative Recognition Human Thymocyte Murine Thymocyte Thymic Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • C. Terhorst
  • J. Borst
  • P. Lerch
  • M. van de Rijn
  • P. Snow
  • H. Spits
  • J. de Vries

There are no affiliations available

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