Abstract
The progressive diversification of T-lymphocytes begins within the thymus gland. Since cell-cell interactions may play a major role in this process, the study of the expression of thymic surface markers would aid our understanding of thymic differentiation. On murine thymocytes, selective expression of genes coding for cell surface markers has been studied with alloantisera [l]. More recently, monoclonal antibodies have made possible the study of selective expression of cell surface glycoproteins on human thymocytes. Thus, as in the mouse, early and late events in the thymic differentiation have been recognized [2]. Although the precise function of these thymic differentiation antigens remains to be determined, it seems plausible that they may govern associative recognition among cooperative cells sets. One could therefore surmise that inappropriate expression of some of the thymic differentiation antigens may playa role in leukemogensis.
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References
Owen JTT, Raff MC (1970) J Exp Med 132: 1216–1232
Reinherz EL, Schlossman SF (1980) Cell 19:821–827
McMichael AJ, Pilch J, Galfre G, Mason DY, Fabre JW, Milstein C (1979) Eur J Immunol 9: 205–210
Poppema S, Bahn AK, Reinherz EL, Mc Cluskey RT, Schlossman SF (1981) J Exp Med 153: 30–41
Terhorst C, Van Agthoven A, LeClair K, Snow P, Reinherz EL, Schlossman SF (1981) Cell 23: 771–780
Van Agthoven A, Terhorst C (1982) J Immunol 128: 426–432
Lerch P, Van de Rijn M, Schrier P, Terhorst C (to be published) Human Immunol
Rothenberg E (1982) J Exp Med 155: 140–154
Kung PC, Goldstein G, Reinherz EL, Schlossman SF (1979) Science 206:347–349
Van Wauwe JP, DeMey JR, Goossens JG (1980) J Immunol 124:2708–2713
Reinherz EL, Hussey RE, Schlossman SF (1980) Eur J Immunol 10:758–761
Borst J, Prendiville MA, Terhorst C (1982) J Immunol 128: 1560–1565
Borst J, Alexander S, Elder J, Terhorst C (to be published) J Immunol
Borst J, Prendiville MA, Terhorst C (to be published) J Biol Chem
Terhorst C, Van Agthoven A, Reinherz E, Schlossman SF (1980) Science 209:520–523
Snow p, Spits H, De Vries J, Terhorst C (to be published) Hybridoma
Snow P, Terhorst C (to be published) J Immunol
Nakayama E, Shiku H, Stockert E, Oettgen HF, Old LJ (1978) Proc Natl Acad Sci USA 78: 1977–1981
Spits H, De Vries J, Terhorst C (1981) Cell Immunol 59:435–447
Spits H, Ijssel H, Terhorst C, De Vries J (1982) J Immunol 128:95–99
Spits H, Borst J, Terhorst C, De Vries J (to be published) J Immunol
Spits H, Breuning M, Ivany P, De Vries J (to be published) Immunogenetics
Tosi R, Tanyaki N, Centis D, Ferrara GB, Pressman D (1978) J Exp Med 148: 1592–1587
Landegren U, Ramstedt U, Axberg I, Ullberg M, Jondal M, Wigzell H (1982) J Exp Med 155: 1579–1584
Chang TW, Kung PC, Gingras SP, Goldstein G (1981) Proc Natl Acad Sci USA 78:4500–4506
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© 1983 Springer-Verlag Berlin Heidelberg
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Terhorst, C. et al. (1983). Structural and Functional Aspects of the T-Cell Differentiation Antigens T3, T6, and T8. In: Neth, R., Gallo, R.C., Greaves, M.F., Moore, M.A.S., Winkler, K. (eds) Modern Trends in Human Leukemia V. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68761-7_85
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DOI: https://doi.org/10.1007/978-3-642-68761-7_85
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