Structural and Functional Aspects of the T-Cell Differentiation Antigens T3, T6, and T8
The progressive diversification of T-lymphocytes begins within the thymus gland. Since cell-cell interactions may play a major role in this process, the study of the expression of thymic surface markers would aid our understanding of thymic differentiation. On murine thymocytes, selective expression of genes coding for cell surface markers has been studied with alloantisera [l]. More recently, monoclonal antibodies have made possible the study of selective expression of cell surface glycoproteins on human thymocytes. Thus, as in the mouse, early and late events in the thymic differentiation have been recognized . Although the precise function of these thymic differentiation antigens remains to be determined, it seems plausible that they may govern associative recognition among cooperative cells sets. One could therefore surmise that inappropriate expression of some of the thymic differentiation antigens may playa role in leukemogensis.
KeywordsTrypsin Treatment Associative Recognition Human Thymocyte Murine Thymocyte Thymic Differentiation
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- 7.Lerch P, Van de Rijn M, Schrier P, Terhorst C (to be published) Human ImmunolGoogle Scholar
- 13.Borst J, Alexander S, Elder J, Terhorst C (to be published) J ImmunolGoogle Scholar
- 14.Borst J, Prendiville MA, Terhorst C (to be published) J Biol ChemGoogle Scholar
- 16.Snow p, Spits H, De Vries J, Terhorst C (to be published) HybridomaGoogle Scholar
- 17.Snow P, Terhorst C (to be published) J ImmunolGoogle Scholar
- 18.Nakayama E, Shiku H, Stockert E, Oettgen HF, Old LJ (1978) Proc Natl Acad Sci USA 78: 1977–1981Google Scholar
- 21.Spits H, Borst J, Terhorst C, De Vries J (to be published) J ImmunolGoogle Scholar
- 22.Spits H, Breuning M, Ivany P, De Vries J (to be published) ImmunogeneticsGoogle Scholar