Human Interferon-Beta in the Treatment of Non-Hodgkin Lymphoma

  • W. Siegert
  • D. Huhn
  • H. Theml
  • U. Fink
  • P. Kaudewitz
  • G. Riethmüller
  • W. Wilmanns
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 28)

Abstract

Interferon has potent antiviral, anti-proliferative, and immunomodulating properties [9, 10]. Leukocyte and fibroblast interferon have been applied in the treatment of human malignancies. Due to the limited availability of interferon, only small numbers of patients have been treated so far. According to the literature a total of 106 patients with malignant lymphomas have been treated, including five patients with Hodgkin’s disease, 65 patients with multiple myeloma, nine patients with acute lymphatic leukemia, 14 patients with chronic lymphatic leukemia, nine patients with nodular poorly differentiated lymphocytic non-Hodgkin lymphoma, and four patients with diffuse histiocytic non-Hodgkin lymphoma. Eight of the 106 patients achieved complete remission and 56 showed partial regression [1, 2, 4, 5, 7, 8, 12–15].

Keywords

Fatigue Toxicity Lymphoma Leukemia Interferon 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aare (1979) In: Dunnick JK, Galasso GJ (1979) Clinical trials with exogenous interferon: Summary of a meeting. J Infect Dis 139: 109–123Google Scholar
  2. 2.
    Ahlström M, Dohlwitz A, Strander H, Carlström G, Cant ell K (1974) Interferon in acute leukemia m children. Lancet 1: 166–167CrossRefGoogle Scholar
  3. 3.
    Billiau A (1981) The clinical applicability of human fibroblast interferon. A review of pharmacokinetics, toxicology and effectiveness in viral disease. In: The biology of the interferon system. Antiviral Res 1: 27–28CrossRefGoogle Scholar
  4. 4.
    Blomgren H, Cantell K, Johansson B, Lagergren C, Ringborg U, Strander H (1976) Interferon therapy in Hodgkin’s disease. Acta Med Scand 199: 527–532PubMedCrossRefGoogle Scholar
  5. 5.
    Emödi In: Dunnick JK, Galasso GJ (1979) Clinical trials with exogenous interferon: Summary of a meeting. J Infect Dis l39: 109–123Google Scholar
  6. 6.
    Fink U, Siegert W, Huhn D, Wilmanns W, Berdel WE, Emmerich B, Hutsteiner H, Wüst I, Rastetter J, Theml H, Riethmüller G (1982) Fibroblasten-Interferon-Therapie bei Non-Hodgkin-Lymphomen mit niedrigem Malignitätsgrad. Blut 44: 121–124PubMedCrossRefGoogle Scholar
  7. 7.
    Gutterman JU, Blumenschein GR, Alexanian R, Yap HY, Buzdar AU, Cabanillas F, Hortobagyi GN, Hersh EM, Rasmussen SL, Harmon M, Kramer M, Pestka S (1980) Leukocyte interferon-induced tumor regression in human metastatic breast multiple myeloma and malignant lymphoma. Ann Intern Med 93:399–406PubMedGoogle Scholar
  8. 8.
    Hill NO, Loeb E, Pardue AS, Dorn GL, Khan A, Hill JM (1979) Human leukocyte interferon responsiveness in acute leukemia. J Clin Hematol Oncol 9: 137–149Google Scholar
  9. 9.
    Krim M (1980a) Towards tumor therapy with interferons. Part I. Interferons: Production and properties. Blood 55:711–721Google Scholar
  10. 10.
    Krim M (1980b) Towards tumor therapy with interferons. Part II. Interferons: In vivo effects. Blood 55:875–884Google Scholar
  11. 11.
    Lennert K (1978) Classification of non-Hodgkin’s lymphoma. In: Lennert K, Mohri N, Stein H, Kaiserling E, Müller-Hermelinck HK (eds) Malignant lymphomas other than Hodgkin’s disease. Springer, Berlin Heidelberg New York, p 83Google Scholar
  12. 12.
    Mellstedt H, Bjorkholm M, Johansson B, Ahre A, Holm G, Strander H (1979) Interferon therapy in myelomatosis. Lancet 1:245–247PubMedCrossRefGoogle Scholar
  13. 13.
    Merigan TC, Sikora K, Breeden JH, Rosenberg SA (1979) Preliminary observations on the effect of human leukocyte interferon in non-Hodgkin lymphoma, N Engl J Med 229: 1449–1453Google Scholar
  14. 14.
    Misset JL, Goutner A, Mathe G (1980) Clinical and immunological experience of interferon in B-cell malignancies. 6th Annual meeting of the European Society of Medical Oncology (abstr) Cancer Immunol Immunother Suppl 5Google Scholar
  15. 15.
    Osserman EF, Sherman WH, Alexanian R, Gutterman JU, Humphrey RL (1981) Human leukocyte interferon in multiple myeloma: In: De Maeyer E, Galasso G, Schellekens H (eds) The biology of the interferon system. Elsevier/North Holland Biomedical, Amsterdam, pp 409–413Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • W. Siegert
  • D. Huhn
  • H. Theml
  • U. Fink
  • P. Kaudewitz
  • G. Riethmüller
  • W. Wilmanns

There are no affiliations available

Personalised recommendations