Abstract
Apart from their role in the absorption of lipids and lipid-soluble vitamins, bile acids are the organism’s main means of eliminating cholesterol. They also exert an important cathartic function in the small intestine, ensuring the liquidness of its contents and making them accessible to absorption. In the colon, too, their laxative action is thought to be of physiological importance: the rare syndrome of congenital bile acid deficiency is accompanied by severe constipation. Effective enterohepatic recirculation is a most economical manner of conserving bile acids.
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References
Adler RD, Metzger AL, Grundy SM (1974) Biliary lipid secretion before and after cholecystectomy in American Indians with cholesterol gallstones. Gastroenterology 66: 1212
Admirand WH, Small DM (1968) The physicochemical basis of cholesterol gallstone formation in man. J Clin Invest 47: 1043
Ahlberg J, Angelin B, Einarsson K, Leijd B (1978) Biliary lipid composition and bile acid kinetics in patients with agenesis of the gallbladder with a note on the frequency of this anomaly. Acta Chir Scand [Suppl] 482: 15
Aldini R, Festi D, Roda A, Sama C, Mazzella G, Roda E, Barbara L (1976) Biliary lipid metabolism after cholecystectomy. IX. Winter Meeting, Ital Ass Stud Liver, Rome, 11–12 Dec
Almond HR, Vlahcevic ZR, Bell CC, Gregory DH, Swell L (1973) Bile acid pools, kinetics, and biliary lipid composition before and after cholecystectomy. N Engl J Med 289: 121
Ashkin JR, Lyon DT, Wagner CI, Shull SD, Soloway RD (1976) The role of the sphincter of Oddi and gallbladder (GB) in the regulation of bile salt output (BSO). Gastroenterology 70: 977 (A)
Ashkin JR, Lyon DT, Shull SD, Wagner CI, Soloway RD (1978) Factors affecting delivery of bile to the duodenum in man. Gastroenterology 74: 560
Bell CC, Almond HR, Vlahcevic ZR, Gregory DH, Swell L (1973) The effect of cholecystectomy on bile acid pool size, kinetics, and biliary lipid composition in patients with cholesterol gallstones. Gastroenterology 64: 879 (A)
Bergmann K von, Mok HYI, Grundy SM (1975) Regulation of bile acid (B.A.) pool size in man. Gastroenterology 69: 877 (A)
Bergmann K von (1977) Der Einfluß der Gallenblase auf die Anzahl der enterohepatischen Zirkulationen des Gallensäurenpools beim Menschen. Z Gastroenterologie 15 [Suppl]:56 A
Boyer JL, Bloomer JR, Maddry WC, Tilson D (1974) Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones. Yale J Biol Med 47: 211
Cahling E, Jönsson J, Nilsson S, Schersten T (1973) Biliary lipid composition in normolipidemic and prebeta hyperlipoproteinemic gallstone patients. Scand J Gastroenterol 8: 449
Capron JP, Delamarre J, Canarelli JP, Brousse N, Dupas J-L (1978) La cholecystectomie favorise-t-elle l’apparition du cancer rectocolique? Gastroenterol Clin Biol 2: 383
Choluj B, Čeklovský J, Nožička Z (1979) Cholecystectomy and carcinomas of the large bowel. Čs Gastroent Vyz 33: 13
Cohn MS, Schwartz SI, Faloon WW, Adams JT (1979) Effect of sphincteroplasty on gallbladder function and bile composition. Ann Surg 189: 317
Czygan P, Seitz H, Waldherr R, Stiehl A, Kommereil B (1981) Untersuchungen zur kokarzinogenen Wirkung von Ursodesoxycholsäure und Chenodesoxycholsäure beim Dimethylhydrazininduzierten Kolonkarzinom der Ratte. Z Gastroenterologie 19: 532
Erlinger S (1977) Bile acid-independent secretion. In: Bianchi L, Gerok W, Sickinger K (eds) Liver and bile. MTP, Lancaster, p 55
Grundy SM, Metzger AC, Adler RD (1972) Mechanisms of lithogenic bile formation in American Indian women with cholesterol gallstones. J Clin Invest 51: 3026
Hager J, Riedler L (1978) Zusammenhang zwischen Cholezystektomie und Kolonkarzinom? Z Allgemeinmedizin 54: 1607
Heaton KW, Read AE (1969) Association of gallstones with disorders of the terminal ileum. Gut 10: 414
Heaton AE, Read KW (1969) Gallstones in patients with disorders of the terminal ileum and disturbed bile salt metabolism. Br Med J 3: 494
Hepner G, Hofmann AF, Malagelada JR, Szczepanik P, Klein P (1974) Increased bacterial degradation of bile acids in cholecystectomized patients. Gastroenterology 66: 556
Hill MJ, Crowther JS, Drasar BS, Hawksworth G, Aries VC, Williams REO (1971) Bacteriae and etiology of cancer of large bowel. Lancet 1: 95
Hill MJ, Aries VC (1971) Faecal steroid composition and its relationship to cancer of the large bowel. J Path 104: 129
Hofmann AF (1977) The enterohepatic circulation of bile acids in man. Clin Gastroenterol 6: 3
Hofmann AF (1978) The clinical physiology of the enterohepatic circulation of bile acids. Ital J Gastroenterol 10 [Suppl 1]: 30
Hutton SW, Sievert CE, Vennes JA, Duane WC (1981) The effect of sphincterotomy on gallstone formation in the prairie dog. Gastroenterology 81: 663
Kimball A, Pertsemlidis D, Panveliwalla D (1976) Composition of biliary lipids and kinetics of bile acids after cholecystectomy in man. Am J Dig Dis 21: 776
Kurtz W, Leuschner U, Hellstern A (1978) Der Einfluß von Chenodesoxycholsäure auf die Konzentration nichtsulfatierter Gallensäuren in der Dünn- und Dickdarmschleimhaut der Ratte. Z Gastroenterologie 16: 553
Kurtz W, Leuschner U, Klump P, Schneider M, Berk G, Erb W, Strohm WD (1980) Bile acids in colorectal carcinoma patients. Hepato-Gastroenterology 27 [Suppl]: 200
Kurtz W, Leuschner U, Klump P, Schneider M, Berk G, Erb W, Strohm WD (1980) Les acides biliaires dans les cancers rectocoliques. Gastroenterol Clin Biol 4:57 A
Kurtz W, Leuschner U, Klump P, Schneider M, Berk G, Erb W, Strohm WD (1980) Bile acids in tumor tissue, intestinal mucosa, serum, and feces of patients with colorectal carcinoma. Gastroenterology 78: 1201
Kurtz W, Leuschner U, Scholz G, Michel J (1980) Differences in chenodeoxycholic acid (CDCA) and ursodeoxycholic acid ( UDCA) influence on rat small intestinal wall bile acids. Ital J Gastroenterol 12: 331
Kurtz W, Leuschner U, Scholz G (1977) Short term alterations of jejunal and ileal wall sulfated and nonsulfated bile acid concentrations after oral application of chenodeoxycholic acid (CDCA). Arch Hell Med Soc 3 [Suppl]: 51
Kurtz W, Leuschner U, Strohm WD, Franz J, Banzer W (1981) Different influence of chenodeoxycholic acid (CDCA) and ursodeoxycholic acid ( UDCA) on bile acid concentrations in rat colonic wall and contents. Gastroenterology 80: 1200
Kurtz W, Leuschner U, Strohm WD, Banzer W, Franz J (1981) Unterschiedlicher Einfluß von Chenodesoxycholsäure (CDC) und Ursodesoxycholsäure ( UDC) auf die Gallensäuren in Kolonwand und Koloninhalt der Ratte. Z Gastroenterologie 19: 482
Kurtz W, Leuschner U, Strohm WD, Kon H (1981) Die Gallensäuren der Ileum- und Kolonmukosa bei M. Crohn und Kolonkarzinom. Z Gastroenterologie 19: 524
Kurtz W, Leuschner U, Schneider S, Phillip J, Hagenmüller F, Classen M (1982) Persistent diurnal rhythm of biliary lithogenicity after cholecystectomy and papillotomy. Gastroenterology 82: 1107
Kurtz W, Leuschner U, Strohm WD, Classen M (1980) Metabolische Aspekte zur Epidemiologie des Kolonkarzinoms. Inn Med 7: 76
Leuschner U (1976) Medikamentöse Gallensteinauflösung. Z Gastroenterologie 14: 212
Leuschner U, Czygan P, Liersch M, Fröhling W, Stiehl A (1977) Morphologische Untersuchungen zur Toxizität sulfatierter und nichtsulfatierter Lithocholsäure an der perfundierten Rattenleber. Z Gastroenterologie 15: 246
Leuschner U, Kurtz W, Leuschner M (1980) Will UDCA dissolve gallstones faster than CDCA? Animal experiments and clinical observations. Hepato-Gastroenterology 27 [Suppl]: 275
Leuschner U, Leuschner M (1979) Cholelitholyse oder Cholezystektomie? DMW 104: 629
Leuschner U, Reber E, Erb W (1977) Erfahrungen bei der Behandlung von Gallensteinpatienten mit Chenodesoxycholsäure. DMW 102: 156
Malagelada JR, Go VLW, Summerskill WHJ, Gamble WS (1973) Bile acid secretion and biliary bile acid composition altered by cholecystectomy. Am J Dig Dis 18: 455
Meyer PD, Den Besten L, Mason EE (1979) The effects of a high fiber diet on bile acid pool size, bile acid kinetics, and biliary lipid secretion rates in the morbidly obese. Surgery 85: 311
Metzger A, Adler R, Heymsfield S, Grundy SM (1973) Diurnal variation in biliary lipid composition. N Engl J Med 288: 333
Nilsson S, Schersten T (1969) Importance of bile acids for phospholipid secretion into human bile. Gastroenterology 57: 525
Northfield TC, Hofmann AF (1973) Biliary lipid secretion in gallstone patients. Lancet 1: 747
O’Brien JJ, Shaffer EA, Williams LF, Small DM, Lynn J, Wittenberg J (1974) A physiological model to study gallbladder function in primates. Gastroenterology 67: 119
Peters H, Keimes HM (1979) Die Cholezystektomie als prädisponierender Faktor in der Genese des kolorektalen Karzinoms? DMW 104: 1581
Pomare EW, Heaton KW (1973) The effect of cholecystectomy on bile salt metabolism. Gut 14: 753
Pomare EW, Heaton KW (1973) Alteration of bile salt metabolism by dietary fibre (bran). Br Med J 4: 262
Pomare EW, Heaton KW, Low-Beer TS, Espiner HJ (1976) The effect of wheat bran upon bile salt metabolism and upon the lipid composition of bile in gallstone patients. Am J Dig Dis 21: 521
Redinger, personal communication
Redinger N, Small DM (1972) Bile composition, bile salt metabolism and gallstones. Arch Int Med 130: 618
Redinger N (1976) The effect of loss of gallbladder function on biliary lipid composition in subjects with cholesterol gallstones. Gastroenterology 71: 470
Roda E, Aldini R, Mazzella G, Roda A, Sama C, Festi D, Barbara L (1978) Enterohepatic circulation of bile acids after cholecystectomy. Gut 19: 640
Röttger P, Kurtz W, Desnizza V (in preparation) Information retrieval aus Routine-Obduktionen
Shaffer EA, Small DM (1971) The influence of cholecystectomy and obesity on biliary lipid secretion in cholesterol gallstone disease. Dig Dis Week, Florida, Miami Beach, 24–27 May 1971
Shaffer EA, Braasch JW, Small DM (1972) Bile composition at and after surgery in normal persons and patients with gallstones. N Engl J Med 287: 1317
Shefer S, Hauser S, Berkesky I, Mosbach EH (1969) Feedback regulation of bile acid biosynthesis in the rat. J Lip Res 10: 646
Simmons F, Ross APJ, Bouchier IAD (1972) Alterations in hepatic bile composition after cholecystectomy. Gastroenterology 63: 466
Sklan D, Budowksi P, Hurwitz S (1976) Site of bile acid absorption in the rat. Lipids 11: 467
Small DM, Shaffer EA, Braasch JW (1972) Bile composition at and after surgery in normals, pigment stone patients and cholesterol stone patients. In: Back P, Gerok W (eds) Bile acids in human diseases. Schattauer, Stuttgart New York, p 175
Soloway RD, Schoenfield LJ (1975) Effects of meals and interruption of enterohepatic circulation on flow, lipid composition, and cholesterol saturation of bile in man after cholecystectomy. Am J Dig Dis 20: 99
Turnbull PRG, Isbister WH (1977) Is there an increased risk of large bowel cancer following cholecystectomy? Int Conference on Gastrointestinal Cancer, Tel Aviv, 6–11 Nov 1977
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Kurtz, W., Classen, M. (1983). The Role of the Gallbladder and the Sphincter of Oddi in the Regulation of Enterohepatic Bile Acid Circulation and Biliary Lipid Secretion. In: Csomós, G., Thaler, H. (eds) Clinical Hepatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68748-8_9
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