Abstract
Chronic hepatitis is a heterogeneous syndrome with different underlying etiologies. Viruses (hepatitis B virus, non-A, non-B viruses), drugs and even alcohol are regarded as etiological agents. A further subgroup is autoimmune-type chronic hepatitis in which an immunogenetic predisposition is of major importance. Primary biliary cirrhosis has to be separated from these subgroups of chronic hepatitis.
This work was supported by the Deutsche Forschungsgemeinschaft, grant Me 244/13
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alberti A, Realdi G, Bortolotti F, Rigoli AM (1977) T-lymphocyte cytotoxicity to HBsAg-coated target cells in hepatitis B virus infection. GUT 18: 1004–1009
Alexander JJ, Bey EM, Geddes EW, Lecatsas G (1976) Establishment of a continuously growing cell line from primary carcinoma of the liver. S Afr Med J 50: 2124
Bach MA, Bach JF (1981) The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases. Clin Exp Immunol 45: 449–456
Behrens UJ, Paronetto F (1979) Studies on ‘liver-specific antigens.’ I. Evaluation of the liver specificity of ‘LSP’ and ‘LP-2. ’ Gastroenterology 77: 1045–1052
Behrens UJ, Vernace S, Paronetto F (1979) Studies on ‘liver-specific’ antigens. II. Detection of serum antibodies to liver and kidney cell membrane antigens in patients with chronic liver disease. Gastroenterology 77: 1053
Berg PA, Doniach D, Roitt IM (1967) Mitochondrial antibodies in primary biliary cirrhosis. I. Localization of the antigen to mitochondrial membranes. J Exp Med 126: 277–293
Berg PA, Binder T, Lindner H, Bannaski H, Maas D, Henning H, Brügel H (1975) Heterogenität mitochondrialer Autoantikörper. Dtsch Med Wochenschr 100: 1123–1127
Berg PA, Wiedmann KH, Sayers T, Klöppel G (1980) Serological classification of chronic cholestatic liver disease by the use of two different types of antimitochondrial antibodies. Lancet 11: 1329–1332
Berg PA, Baum H (1980) Serology of primary biliary cirrhosis. Springer Sem Immunopathol 3: 355–373
Chisari FV (1980) Liver-specific protein in perspective. Gastroenterology 78: 168–170
Chisari FV, Castle KL, Xavier C, Anderson DS (1981) Functional properties of lymphocyte subpopulations in hepatitis B virus infection. I. Suppressor cell control of T lymphocyte responsiveness. J Immunol 126: 38–44
Chisari FV, Bieber MS, Josepho A, Xavier, Anderson DS (1981) Functional properties of lymphocyte subpopulations in hepatitis B virus infection. II. Cytotoxic effector cell killing of targets that naturally express hepatitis B surface antigen and liver-specific lipoprotein. J Immunol 126: 45–49
Cochrane AMG, Moussouros A, Thomson AD et al. (1976) Antibody-dependent cell-mediated ( K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis. Lancet 1: 441–444
Dienstag JL, Bhan AK (1980) Enhanced in vitro cell-mediated cytotoxicity in chronic hepatitis B virus infection: absence of specificity for virus-expressed antigen on target cell membranes. J Immunol 125: 2269–2276
Doniach D (1979) Diagnostische Autoantikörperbestimmungen bei Lebererkrankungen. In: Kühn HA, Wernze H (Hrsg) Klinische Hepatologie. Thieme, Stuttgart, S 3.50–3. 64
Eddleston ALWF, Williams R (1974) Inadequate antibody response to HBsAg or suppressor T-cell defect in development of active chronic hepatitis. Lancet II: 1543–1545
El Sheikh N, Osman CG, Cullens H, Eddleston ALWF, Williams R (1978) T-lymphocyte-mediated cytotoxicity in HBsAg-positive liver disease. Clin Exp Immunol 31: 158–165
Facchini A, Stefanini GF, Bernardi M, Miglio F, Gasbarrini G, Labo G (1978) Lymphocytotoxicity test against rabbit hepatocytes in chronic liver diseases. GUT 19: 189–193
Gerber MA, Lebwohl N, Thung SN, Bodenheimer H, Schaffner F (1979) Antibodies to liver-specific membrane protein in liver and kidney disease ( Abstr ). Gastroenterology 76: 1281
Gerber MA, Garfinkel E, Hirschmann SZ, Thung SN, Panagiotatos T (1981) Immune and enzyme histochemical studies of a human hepatocellular carcinoma cell line producing hepatitis B surface antigen. J Immunol 126: 1085–1090
Geubel AP, Keller RH, Summerskill WHJ, Dickson ER, Tomasi TB, Shorter RG (1976) Lymphocyte cytotoxicity and inhibition studies with autologous liver cells: observations in chronic active liver disease and the primary biliary cirrhosis syndrome. Gastroenterology 71: 450–456
Hamblin TJ (1981) Significance of antimitochondrial antibodies. Lancet 11: 1411–1412
Herberman RB, Djeu JY, Kay HD, Ortaldo JR, Riccardi C, Bonnard GD, Holden HT, Fagnani R, Santoni A, Puccetti P (1979) Natural killer cells: characteristics and regulation of activity. Immunol Rev 44: 43
Hodgson HJF, Wands DR, Isselbacher KJ (1978) Alteration in suppressor cell activity in chronic active hepatitis. Proc Nat Acad Sci USA 75: 1549–1553
Hopf U, Meyer zum Büschenfelde KH, Arnold W (1975) Detection of a cytophilic autoantibody in chronic active hepatitis. Lancet 1: 690–1
Hopf U, Meyer zum Büschenfelde KH, Arnold W (1976) Detection of a liver membrane autoantibody in HBsAg-negative chronic active hepatitis. N Engl J Med 294: 578–582
Hütteroth TH, Meyer zum Büschenfelde KH (1978) Clinical relevance of the liver-specific lipoprotein ( LSP ). Acta Hepato-Gastroenterol 25: 243–253
Hütteroth TH, Meyer zum Büschenfelde KH (1978) Antigenic relationship between Chang liver cells and human hepatocytes. Klin Wochenschr 56: 525–527
Hütteroth TH, Meyer zum Büschenfelde KH (1978) IgG binding to the plasma membrane of Chang liver cells in chronic active hepatitis. J Clin Lab Immunol 1: 91–94
Hütteroth TH, Poralla T, Meyer zum Büschenfelde KH (1981) Spontaneous cell-mediated (SCMC) and antibody-dependent cellular cytotoxicity ( ADCC) in patients with acute and chronic active hepatitis. Klin Wochenschr 59: 699–706
Hütteroth TH, Poralla T, Meyer zum Büschenfelde KH (1982) Cellular cytotoxicity against the human hepatoma cell line PLC/PRF/5 in patients with hepatitis B virus induced chronic active hepatitis (CAH) and non-A, non-B (NANB) CAH 2: 285–291
Jensen DM, McFarlane IG, Portmann BS, Eddieston DM, Williams R (1978) Detection of antibodies directed against liver-specific lipoprotein in patients with acute and chronic active hepatitis. N Engl J Med 299: 1–7
Kakumu S, Hara T, Goji H, Sakamoto N (1978) Lymphocyte cytotoxicity against Chang liver cells in chronic active hepatitis. Cell Immunol 36: 46
Kakamu S, Arakawa Y, Goji H, Kashio T, Yata K (1979) Occurence and significance of antibody to liverspecific lipoprotein by double-antibody immunoprecipitation method in sera of patients with acute and chronic liver diseases. Gastroenterology 76: 665–672
Kawanishi H, MacDermott RP (1979) K-cell-mediated antibody dependent cellular cytotoxicity in chronic active liver diseases. Gastroenterology 76: 151–158
Klatskin G, Kantor FS (1972) Mitochondrial antibody in primary biliary cirrhosis and other diseases. Ann Intern Med 77: 533–541
Labro MT, Andrieu MC, Weber M, Homberg JC (1978) A new pattern of non-organ- and non-species-specific anti-organelle antibody detected by immunofluorescence: the mitochondrial antibody number 5. Clin Exp Immunol 31: 357–366
Lebwohl N, Gerber MA (1981) Characterization and demonstration of human liver-specific protein ( LSP) and apo-LSP. Clin Exp Immunol 46: 435–442
Maas D, Schubothe H (1973) Ein Lupus-erythematodes-ähnliches Syndrom mit antimitochondrialen Antikörpern. Dtsch Med Wochenschr 98: 131–139
Mackay IR, Taft GD (1980) HLA associations with autoimmune-type chronic active hepatitis: identification of B8-DRw3 haplotype by family studies. Gastroenterology 79: 95
Mac Sween RNM, Anthony RS, Farguharson M (1981) Antibodies to alcohol-altered hepatocytes in patients with alcoholic liver disease ( Letter ). Lancet 11: 803–804
Manns M, Meyer zum Büschenfelde KH, Hütteroth TH, Hopf U (1980) The liver specific protein: evidence for species-specific and non-species-specific determinants. J Clin Lab Immunol 3: 9–13
Manns M, Meyer zum Büschenfelde KH, Hütteroth TH, Hess G (1980) Detection and characterization of liver membrane autoantibodies in chronic active hepatitis by a solid phase radioimmunoassay. Clin Exp Immunol 42: 263–272
Manns M, Meyer zum Büschenfelde KH, Hess G (1980) Autoantibodies against liver-specific membrane lipoprotein in acute and chronic liver diseases: studies on organ-, species-, and disease-specificity. GUT 21: 955–961
Manns M, Arnold W, Meyer zum Büschenfelde KH, Nagai S, Hoffmann H (1981) Studies on anti LSP autoantibodies in acute and chronic non-B hepatitis — Evidence for the lack of anti LSP in non-A, non-B ( NANB) viral hepatitis. Klin Wochenschr 59: 685–689
Manns M, Meyer zum Büschenfelde KH (1982) A mitochondrial antigen-antibody system in cholestatic liver disease detected by radioimmunoassay. Hepatology 2: 1–7
Manns M, Meyer zum Büschenfelde KH (1981) Fractionation of the liver antigen fraction ‘LSP’ and characterization of its antigenic determinants by autoantibodies and a heterologous anti ‘LSP’ serum. GUT 23: 14–20
McFarlane IG, Wojcicka BM, Zucker GM, Eddieston ALWF, Williams R (1977) Purification and characterization of human liver-specific membrane lipoprotein ( LSP ). Clin Exp Immunol 27: 381–390
Meliconi R, Baraldini M, Stefanini GF, Facchini A, Miglio F, Bortolotti F, Alberti A, Realdi G, Amoroso P (1981) Antibodies against human liver-specific protein (LSP) in acute and chronic viral hepatitis types A, B and non-A, non-B. Clin Exp Immunol 46: 382–390
Meyer zum Büschenfelde KH, Miescher PA (1972) Liver specific antigens: purification and characterization of human liver-specific membrane lipoprotein ( LSP ). Clin Exp Immunol 10: 89–102
Meyer zum Büschenfelde KH, Manns M, Hütteroth TH, Hopf U, Arnold W (1979) LM-Ag and LSP — two different target antigens involved in the immunopathogenesis of chronic active hepatitis? Clin Exp Immunol 37: 205–212
Meyer zum Büschenfelde KH, Hütteroth TH, Arnold W, Hopf U (1979) Immunologic liver injury: the role of hepatitis B viral antigens and liver membrane antigens as targets. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol VI. Grune & Stratton, New York, pp 407–424
Meyer zum Büschenfelde KH, Hütteroth TH, Manns M, Möller B (1980) The role of liver membrane antigens as targets in autoimmune type liver diseases. Springer Sem Immunopathol 3: 297–315
Mieli Vergani G, Vergani D, Jenkins PJ, Portmann B, Mowat AP, Eddieston ALWF, Williams R (1979) Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis. Clin Exp Immunol 38: 16–21
Miyachi K, Gupta RC, Dickson ER, Tan EM (1980) Precipitating antibodies to mitochondrial antigens in patients with primary biliary cirrhosis. Clin Exp Immunol 39: 599–606
Nouri K, Hegarty JE, Eddieston ALWF, Williams R (1981) A suppressor cell defect in autoimmune chronic active hepatitis is reversed by prednisolone (Abstr). 16th Meeting EASL, Lisbon 1981
Perperas A, Tsantoulas D, Portmann B, Eddleston ALWF, Williams R (1981) Autoimmunity to a liver membrane lipoprotein and liver damage in alcoholic liver disease. GUT 22: 149–152
Rizetto M, Bianchi B, Doniach D (1974) Characterization of the microsomal antigen related to a subclass of active chronic hepatitis. Immunology 26: 589
Routhier G, Epstein O, Janossy G, Thomas HC, Sherlock S (1981) Effects of cylosporin A an suppressor and inducer T lymphocytes in primary biliary cirrhosis. Lancet II: 1223–1226
Sayers TJ, Binder T, Berg PA (1979) Heterogeneity of anti-mitochondrial antibodies: characterization and separation of the antigen associated with the pseudolupus erythematosus syndrome. Clin Exp Immunol 37: 68–75
Tage-Jensen U, Arnold W, Dietrichson O, Hardt F, Hopf U, Meyer zum Büschenfelde KH, Nielsen JO (1977) Liver-cell-membrane autoantibody specific for inflammatory liver disease. Br Med J 1: 206–208
Thomas HC, Holden R, Verrier-Jones J, Peacock DB (1976) Immune response to X 174 in man. Primary and secondary antibody production in primary biliary cirrhosis. GUT 17: 844
Thomson AD, Cochrane MAG, McFarlane IG et al. (1974) Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis. Nature 252: 721–722
Tsantoulas D, Perperas A, Portmann B, Eddleston ALWF, Williams R (1980) Antibodies to a human liver membrane lipoprotein ( LSP) in primary biliary cirrhosis. GUT 21: 557–560
Vergani D, Tsantoulas D, Eddleston ALWF, Davis M, Williams R (1978) Sensitisation to halothane-altered liver components in severe hepatic necrosis after halothane anesthesia. Lancet 11: 801–803
Vergani D, Mieli-Vergani G, Alberti A, Neuberger J, Eddleston ALWF, Davis M, Williams R (1980) Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis. N Engl J Med 303: 66–71
Vergani GM, Eddleston ALWF (1981) Autoimmunity to liver membrane antigens in acute and chronic hepatitis. In: Holborow DJ (ed) Clinics in immunology and allergy. Saunders, London, pp 181–198
Vierling JM, Nelson DL, Strober W, Bundy BM, Jones EA (1977) In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis. J Clin Invest 60: 1116–1128
Vogten AJM, Hadzic N, Shorter RG et al. (1978) Cell-mediated cytotoxicity in chronic active liver disease: a new test system. Gastroenterology 74: 883–889
Walker JG, Doniach D, Roitt IM, Sherlock S (1965) Serological tests in diagnosis of primary biliary cirrhosis. Lancet 1: 827–831
Wands JR, Isselbacher KJ (1975) Lymphocyte cytotoxicity to autologous liver cells in chronic active hepatitis. Proc Natl Acad Sci USA 72: 1301–1303
Wands JR, Perrotto JL, Alpert E, Isselbacher KJ (1975) Cell-mediated immunity in acute and chronic hepatitis. J Clin Invest 55: 921–929
Wilson JD, Booth RJ, Bullock JY, Campbell DG (1980) Anti-mitochondrial antibodies associated with labetalol ( Letter ). Lancet 11: 312–313
Zinkernagel RM, Doherty PC (1979) MHC-restricted cytotoxic T cells: studies on the biological role of polymorphs major transplantation antigens determining T cell restriction-specificity function and responsiveness. Adv Immunol 27: 51
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Meyer zum Büschenfelde, KH., Hütteroth, T.H., Manns, M. (1983). Immune Reactions in Liver Diseases. In: Csomós, G., Thaler, H. (eds) Clinical Hepatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68748-8_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-68748-8_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68750-1
Online ISBN: 978-3-642-68748-8
eBook Packages: Springer Book Archive