Abstract
The purpose of using inhalational anaesthetics is to depress brain function, and they do so in a dose-related fashion. Unless this effect is itself considered toxic, then respiratory or circulatory arrest with high anaesthetic concentrations should not be considered toxicity. These are only magnifications of the usual pharmacological effects in accordance with predictable dose-response curves, and are totally reversible simply by decreasing the dose [1].
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References
Steen PA, Michenfelder JD (1979) Neurotoxicity of anaesthetics. 50: 437–453
Siesjö BK (1978) Brain energy metabolism. John Wiley & Sons, Chichester New York Brisbane Toronto
Smith AL, Wollman H (1972) Cerebral blood flow and metabolism: Effects of anaesthetic drugs and techniques. Anaesthesiology 36: 378–400
Theye RA, Michenfelder JD (1968) The effect of nitrous oxide on canine cerebral metabolism. Anaesthesiology 29: 1119–1124
Carlsson C, Hagerdal M, Siesjo BK (1976) The effect of nitrous oxide on oxygen consumption and blood flow in the cerebral cortex of the rat. Acta Anaesth Scand 20: 91–95
Stullken EH, Milde JH, Michenfelder JD, Tinker JH (1977) The nonlinear response of cerebral metabolism to low concentrations of halothane, enflurane, isoflurane and thiopental. Anaesthesiology 46: 28–34
Michenfelder JD, Theye RA (1975) In vivo toxic effects of halothane on canine cerebral metabolic pathways. Am J Physiol 229: 1050–1055
Michenfelder JD, Cucchiara RF (1974) Canine cerebral oxygen consumption during enflurane anaesthesia and its modification during induced seizures. Anaesthesiology 40: 575–580
Cohen PJ, Marshall BE (1968) Effects of halothane on respiratory control and oxygen consumption of rat liver mitochondria. In: Fink BR (ed) Toxicity of anaesthetics. Williams &; Wilkins, Baltimore, pp 24–36
Rosenberg H, Haugaard N (1973) The effects of halothane on metabolism and calcium uptake in mitochondria of the rat liver and brain. Anaesthesiology 39: 44 - 52
Smith AL, Hoff JT, Nielsen SL, et al. (1974) Barbiturate protection in acute focal ischaemia. Stroke 5: 1–7
Joas TA, Stevens WC, Eger EI II (1971) Electroencephalic seizure activity in dogs during anaesthesia. Br J Anaesth 43: 739–745
Cohen EN, Brown BW, Wu MC, et al. (1980) Occupational disease in dentistry and chronic exposure to trace anaesthetic gases. J Am Dent Ass 101: 21–31
Bruce DL, Bach MJ (1975) Physiological studies of human performance as affected by traces of enflurane and nitrous oxide. Anaesthesiology 42: 194–196
Stevens WC, Eger EI II, White A, et al. (1975) Comparative toxicities of halothane, isoflurane and diethyl ether at subanaesthetic concentrations in laboratory animals. Anaesthesiology 42: 408–419
Chang LW, Dudley AW Jr, Katz J (1976) Pathological changes in the nervous system following in utero exposure to halothane. Environ Res 11: 40–51
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© 1982 Springer-Verlag Berlin Heidelberg
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Steen, P.A. (1982). The Effects of Inhalational Anaesthetics on the Brain. In: Peter, K., Jesch, F. (eds) Inhalation Anaesthesia Today and Tomorrow. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 150. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68713-6_16
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DOI: https://doi.org/10.1007/978-3-642-68713-6_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11757-5
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