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Ventilatory Effects of Epidural Diamorphine — A Comparison with Epidural Lignocaine

  • G. M. Cooper
  • N. W. Goodman
  • C. Prys-Roberts
  • L. Jacobson
  • G. A. Douglas
  • J. Dye
Part of the European Academy of Anaesthesiology book series (ANAESTHESIOLOGY, volume 2)

Abstract

The administration of opioids by the epidural route pioneered by Behar et al.(1) has achieved great popularity as a means of providing postoperative analgesia. Although morphine has been the commonest opioid to be used by either intrathecal or epidural administration(2–7), other opioids such as pethidine, methadone, buprenorphine, fentanyl and diamorphine have also been used in a search for prolonged analgesia free of undesirable side effects. Although most authors have described the advantages and benefits of epidural or intrathecal opioids, there has been much concern about the wisdom of using such methods of postoperative pain relief on general hospital wards in view of case reports of profound ventilatory depression occurring either shortly after, or many hours after, drug administration(8–11).

Keywords

Mean Arterial Pressure Minute Ventilation Ventilatory Response Epidural Morphine Analogue Pain Score 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • G. M. Cooper
  • N. W. Goodman
  • C. Prys-Roberts
  • L. Jacobson
  • G. A. Douglas
  • J. Dye

There are no affiliations available

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