Abstract
Several clinical investigators have failed to detect a significant cardiac depression from enflurane(1–4) in studies in both isolated cardiac muscle(5, 6), the isolated heart(7) and in intact experimental animals(8). However, it is now well recognised that this anaesthetic — like all other volatile inhalational anaesthetics — has a direct negative inotropic effect. Nevertheless, the overall effects of enflurane on left ventricular function are less clear. In particular, it remains unclear as to whether the complex interplay between simultaneous changes in myocardial contractility, myocardial loading conditions, heart rate, reflex buffering and the institution of mechanical ventilation can induce acute left ventricular dilation and acute left ventricular retrograde heart failure. The aim of the present study was to investigate the effects of enflurane on left ventricular dynamics in chronically instrumented dogs.
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Steinbereithner, K., Gilly, H., Zimpfer, M. (1982). Relationship Between End-diastolic Cardiac Size and Ventricular Function Under Increasing Doses of Enflurane in Intact, Chronically Instrumented Dogs. In: Prys-Roberts, C., Vickers, M.D. (eds) Cardiovascular Measurement in Anaesthesiology. European Academy of Anaesthesiology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68690-0_41
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DOI: https://doi.org/10.1007/978-3-642-68690-0_41
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