Abstract
Alfentanyl is a novel narcotic analgesic with a very short duration of effect. A volunteer receiving a clinically useful dose of 0.5 mg perceives an effect about 20 s after injection, the action is marked after 1 min, maximum from 2 to 4 min, and nearing completion 5 min after injection(1). It has a potency of approximately one third that of fentanyl, and the duration of effect is also approximately one third that of fentanyl; it is also less cumulative than fentanyl(2).
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References
Kay B, Pleuvry BJ (1980) Human volunteer studies of Alfentanyl (R39209), a new short-acting narcotic analgesic. Anaesthesia 35; 952.
Brown JH, Pleuvry BJ, Kay B (1980) Respiratory effects of anew opiate analgesic, R39209, in the rabbit: Comparison with fentanyl. Br J Anaesth 52; 1101.
Sear JW, Stafford MA, Prys-Roberts C (1981) Disposition and metabolism of althesin in patients with cirrhotic liver disease. Br J Anaesth (In press).
Kay B, Stephenson DK (1980) Alfentanyl (R39209): Initial clinical experience with a new narcotic analgesic. Anaesthesia 35; 1197.
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© 1982 Springer-Verlag Berlin Heidelberg
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Kay, B., Cohen, A.T. (1982). Althesin and Alfentanyl for Minor Surgery. In: Prys-Roberts, C., Vickers, M.D. (eds) Cardiovascular Measurement in Anaesthesiology. European Academy of Anaesthesiology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68690-0_19
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DOI: https://doi.org/10.1007/978-3-642-68690-0_19
Publisher Name: Springer, Berlin, Heidelberg
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