Drug Interactions with Local Anaesthetics
Failure of regional anaesthesia usually occurs because of the incorrect positioning of the needle during injection. To date, no satisfactory explanation has been found for the rare failure of spinal anaesthesia. Lund(1) attributes such failure exclusively to faulty injection techniques. Cohen and Knight(2) have observed changes in the pH value of the cerebrospinal fluid which were associated with a simultaneous failure of spinal anaesthesia. Subsequent investigations have been unable to confirm their findings, however.
KeywordsTitration Osteoarthritis Prostaglandin Indomethacin Bupivacaine
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- 1.Lund PC (1971) Principles and Practice of Spinal Anesthesia. Anatomical Aspects and Cerebrospinal Fluid. The Arachnoid, Springfield, Charles C. Thomas, p 51.Google Scholar
- 3.Lund PC (1971) Principles and Practice of Spinal Anesthesia. Physical and Chemical Considerations. Springfield, Charles Thomas, p 97.Google Scholar
- 4.Ziel R and Krupp P (1976) Sognificance of the Membrane Stabilising Effect of Nonnarcotic Analgesics. In: Bonica, J.J. and Albe-Fessard, D.: Advances in Pain Research and Therapy, Vol. 1. New York, Raven Press, p 517.Google Scholar