Drug Interactions with Local Anaesthetics
Failure of regional anaesthesia usually occurs because of the incorrect positioning of the needle during injection. To date, no satisfactory explanation has been found for the rare failure of spinal anaesthesia. Lund(1) attributes such failure exclusively to faulty injection techniques. Cohen and Knight(2) have observed changes in the pH value of the cerebrospinal fluid which were associated with a simultaneous failure of spinal anaesthesia. Subsequent investigations have been unable to confirm their findings, however.
KeywordsMotor Blockade Common Receptor Local Anaesthetics Spinal Anaesthetic Simultaneous Failure
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